| Catalys Pacific, LLC |
| 92.94% | 92.81% | #1 | $2.13亿 | 790.4万股 | $2.14亿 | 790.4万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.8% | 2.21% | #13 | $2.08亿 | 769.3万股 | $2.08亿 | 769.3万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #113 | $1.59亿 | 588.7万股 | $1.21亿 | 448.2万股 | +140.5万股+31.36% | 加仓 |
| Samsara BioCapital, LLC |
| 13.01% | 15.45% | #3 | $1.58亿 | 587.1万股 | $1.59亿 | 587.1万股 | 00.00% | 持仓不变 |
| 富达投资FMR LLC |
| 0.01% | 0.01% | #90 | $1.22亿 | 451.2万股 | $1.32亿 | 486.1万股 | -34.9万股-7.19% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #104 | $1.12亿 | 414.2万股 | $7,953.5万 | 293.6万股 | +120.6万股+41.07% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.11% | — | #19 | $1.07亿 | 395.8万股 | $0 | 0股 | +395.8万股 | 新买入 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.92% | 0.57% | #23 | $7,489.6万 | 277.6万股 | $3,185.8万 | 117.6万股 | +160.0万股+136.05% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #129 | $7,437.8万 | 275.7万股 | $6,648.9万 | 245.4万股 | +30.2万股+12.32% | 加仓 |
| Laurion 资本管理Laurion Capital Management LP |
| 1.73% | 2.64% | #14 | $6,761.6万 | 250.6万股 | $6,046.6万 | 223.2万股 | +27.4万股+12.28% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #88 | $6,104.2万 | 226.2万股 | $3,639.1万 | 134.3万股 | +91.9万股+68.43% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.07% | 1.1% | #20 | $5,693.6万 | 211.0万股 | $5,561.3万 | 205.3万股 | +5.7万股+2.80% | 加仓 |
| 资本世界投资者Capital World Investors |
| 0.01% | <0.01% | #84 | $5,389.5万 | 199.8万股 | $1,078.7万 | 39.8万股 | +159.9万股+401.69% | 加仓 |
| Troluce Capital Advisors LLC |
| 4.94% | 1.09% | #5 | $4,799.1万 | 177.9万股 | $1,774.4万 | 65.5万股 | +112.4万股+171.57% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #79 | $4,412.6万 | 163.6万股 | $4,834.6万 | 178.5万股 | -14.9万股-8.36% | 减仓 |
| Andera Partners |
| 20.8% | 24.38% | #2 | $4,295.0万 | 159.2万股 | $4,312.5万 | 159.2万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #115 | $4,275.3万 | 158.4万股 | $3,525.5万 | 130.1万股 | +28.3万股+21.76% | 加仓 |
| SR ONE CAPITAL MANAGEMENT, LP |
| 4.06% | 4.63% | #6 | $4,219.6万 | 156.4万股 | $4,236.8万 | 156.4万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #110 | $4,062.0万 | 150.6万股 | $2,980.9万 | 110.0万股 | +40.5万股+36.82% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $4,027.0万 | 149.3万股 | $2,218.5万 | 81.9万股 | +67.4万股+82.26% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 5.18% | 5.76% | #4 | $3,966.0万 | 147.0万股 | $3,630.0万 | 134.0万股 | +13.0万股+9.70% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.04% | 0.03% | #59 | $3,859.9万 | 143.1万股 | $2,802.3万 | 103.4万股 | +39.6万股+38.30% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.09% | 0.14% | #51 | $3,833.5万 | 142.1万股 | $4,065.5万 | 150.1万股 | -8.0万股-5.32% | 减仓 |
| Caption管理Caption Management, LLC |
| 0.18% | 0.52% | #41 | $3,800.1万 | 140.8万股 | $8,867.6万 | 327.3万股 | -186.5万股-56.97% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #74 | $3,380.5万 | 125.3万股 | $1,422.9万 | 52.5万股 | +72.8万股+138.54% | 加仓 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.18% | — | #40 | $3,035.3万 | 112.5万股 | $0 | 0股 | +112.5万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #114 | $2,944.0万 | 109.1万股 | $114.6万 | 4.2万股 | +104.9万股+2,478.95% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #76 | $2,892.0万 | 106.8万股 | $3,541.8万 | 97.6万股 | +9.2万股+9.38% | 加仓 |
| Logos Global Management LP |
| 1.22% | — | #17 | $2,832.9万 | 105.0万股 | $0 | 0股 | +105.0万股 | 新买入 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.01% | 0.01% | #73 | $2,797.2万 | 103.7万股 | $2,395.1万 | 88.4万股 | +15.3万股+17.27% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #135 | $2,474.6万 | 91.7万股 | $5,221.6万 | 137.7万股 | -46.0万股-33.39% | 减仓 |
| Davern Capital Partners, LP |
| 3.95% | 3.32% | #7 | $2,316.9万 | 85.9万股 | $1,211.3万 | 44.7万股 | +41.2万股+92.05% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.1% | 0.12% | #48 | $2,310.1万 | 85.7万股 | $2,462.0万 | 67.8万股 | +17.9万股+26.33% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.74% | 0.89% | #25 | $2,213.7万 | 82.0万股 | $2,425.9万 | 89.5万股 | -7.5万股-8.38% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | 0.02% | #100 | $2,176.5万 | 80.7万股 | $9,099.7万 | 335.9万股 | -255.2万股-75.98% | 减仓 |
| Affinity Asset Advisors, LLC |
| 0.91% | 1.05% | #24 | $2,023.5万 | 75.0万股 | $2,031.8万 | 75.0万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #151 | $2,017.2万 | 74.8万股 | $1,914.3万 | 70.7万股 | +4.1万股+5.80% | 加仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.03% | 0.05% | #63 | $2,012.4万 | 74.6万股 | $2,846.2万 | 105.1万股 | -30.5万股-29.01% | 减仓 |
| 安本标准投资Aberdeen Group plc |
| 0.03% | — | #65 | $1,859.6万 | 68.9万股 | $0 | 0股 | +68.9万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #134 | $1,802.2万 | 66.8万股 | $3,885.4万 | 143.4万股 | -76.6万股-53.43% | 减仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.21% | 0.11% | #36 | $1,751.1万 | 64.9万股 | $705.1万 | 26.0万股 | +38.9万股+149.37% | 加仓 |
| Catalio Capital Management, LP |
| 3.29% | 2.48% | #8 | $1,750.3万 | 64.9万股 | $1,189.4万 | 43.9万股 | +21.0万股+47.76% | 加仓 |
| Pale Fire Capital SE |
| 1.17% | 0.87% | #18 | $1,657.3万 | 61.4万股 | $990.5万 | 36.6万股 | +24.9万股+68.01% | 加仓 |
| STEMPOINT CAPITAL LP |
| 2.32% | 2.66% | #10 | $1,626.0万 | 60.3万股 | $1,444.9万 | 53.3万股 | +6.9万股+12.99% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #123 | $1,608.0万 | 59.6万股 | $2,067.3万 | 76.3万股 | -16.7万股-21.90% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #125 | $1,487.9万 | 55.1万股 | $1,199.7万 | 44.3万股 | +10.9万股+24.53% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #122 | $1,406.2万 | 52.1万股 | $1,202.5万 | 44.4万股 | +7.7万股+17.42% | 加仓 |
| Rock Springs Capital Management LP |
| 0.64% | 0.7% | #27 | $1,308.4万 | 48.5万股 | $1,191.3万 | 44.0万股 | +4.5万股+10.28% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #116 | $1,250.2万 | 46.3万股 | $371.6万 | 13.7万股 | +32.6万股+237.17% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #109 | $1,215.1万 | 45.0万股 | $1,016.6万 | 37.5万股 | +7.5万股+20.01% | 加仓 |
