| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 3.17% | 3.67% | #4 | $1.74亿 | 113.5万股 | $1.44亿 | 115.3万股 | -1.8万股-1.57% | 减仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.09% | 0.05% | #35 | $1.47亿 | 96.1万股 | $7,985.2万 | 64.1万股 | +32.0万股+49.95% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #94 | $1.40亿 | 91.8万股 | $8,561.6万 | 68.7万股 | +23.2万股+33.71% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 2.94% | 2.83% | #5 | $1.35亿 | 88.2万股 | $1.10亿 | 88.2万股 | 00.00% | 持仓不变 |
| First Light Asset Management, LLC |
| 7.17% | 10.96% | #2 | $1.18亿 | 77.2万股 | $1.22亿 | 98.1万股 | -20.9万股-21.30% | 减仓 |
| BVF INC/IL |
| 2.63% | 3.82% | #6 | $1.03亿 | 67.3万股 | $1.20亿 | 96.1万股 | -28.8万股-29.99% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #85 | $9,981.8万 | 65.3万股 | $5,721.4万 | 45.9万股 | +19.4万股+42.30% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #64 | $9,763.2万 | 63.9万股 | $5,018.0万 | 40.3万股 | +23.6万股+58.70% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #105 | $7,851.8万 | 51.4万股 | $5,949.5万 | 47.7万股 | +3.7万股+7.65% | 加仓 |
| Frontier资本管理FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.68% | 0.48% | #18 | $7,317.5万 | 47.9万股 | $4,662.3万 | 37.4万股 | +10.5万股+28.02% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.1% | 0.09% | #34 | $6,617.3万 | 43.3万股 | $5,397.5万 | 43.3万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.96% | 0.46% | #12 | $5,079.1万 | 33.2万股 | $2,301.0万 | 18.5万股 | +14.8万股+80.04% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.15% | 0.15% | #28 | $4,852.3万 | 31.8万股 | $3,957.8万 | 31.8万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #92 | $4,221.3万 | 27.6万股 | $2,563.7万 | 20.6万股 | +7.1万股+34.32% | 加仓 |
| Siren, L.L.C. |
| 0.8% | 0.89% | #16 | $3,934.9万 | 25.7万股 | $3,209.6万 | 25.7万股 | 00.00% | 持仓不变 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.02% | 0.02% | #47 | $3,915.0万 | 25.6万股 | $2,431.0万 | 19.5万股 | +6.1万股+31.36% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.47% | 0.48% | #21 | $3,537.5万 | 23.1万股 | $2,905.0万 | 23.3万股 | -1,764股-0.76% | 减仓 |
| EMERALD ADVISERS, LLC |
| 0.83% | 0.64% | #14 | $3,507.0万 | 22.9万股 | $2,013.1万 | 16.2万股 | +6.8万股+42.10% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #112 | $3,283.2万 | 21.5万股 | $2,690.0万 | 21.6万股 | -967股-0.45% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #90 | $3,279.5万 | 21.5万股 | $2,404.6万 | 19.3万股 | +2.2万股+11.24% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #61 | $3,155.7万 | 25.3万股 | $2,751.1万 | 26.3万股 | -9,667股-3.68% | 减仓 |
| MPM BioImpact LLC |
| 1.9% | 1.99% | #9 | $3,117.9万 | 20.4万股 | $2,572.8万 | 20.6万股 | -2,377股-1.15% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #88 | $3,079.5万 | 20.2万股 | $2,420.4万 | 19.4万股 | +7,335股+3.78% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #111 | $2,772.6万 | 18.1万股 | $868.3万 | 13.9万股 | +4.3万股+30.99% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.12% | 0.17% | #30 | $2,597.9万 | 17.0万股 | $2,955.5万 | 23.7万股 | -6.7万股-28.30% | 减仓 |
| First Turn Management, LLC |
| 2.56% | 2.06% | #7 | $2,390.9万 | 15.6万股 | $1,846.0万 | 14.8万股 | +8,357股+5.64% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 0.5% | — | #20 | $2,368.7万 | 15.5万股 | $0 | 0股 | +15.5万股 | 新买入 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 0.7% | 0.64% | #17 | $1,984.3万 | 13.0万股 | $1,319.0万 | 10.6万股 | +2.4万股+22.71% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #126 | $1,970.8万 | 12.9万股 | $1,132.5万 | 9.1万股 | +3.8万股+41.94% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.03% | 0.02% | #45 | $1,837.5万 | 12.0万股 | $1,010.7万 | 8.1万股 | +3.9万股+48.29% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #101 | $1,485.3万 | 9.7万股 | $802.4万 | 6.4万股 | +3.3万股+50.99% | 加仓 |
| NEXTBio Capital Management LP |
| 6.32% | 4.79% | #3 | $1,374.0万 | 9.0万股 | $1,030.7万 | 8.3万股 | +7,223股+8.74% | 加仓 |
| Clio Asset Management LLC |
| 10.49% | 9.48% | #1 | $1,319.5万 | 8.6万股 | $1,131.3万 | 9.1万股 | -4,414股-4.86% | 减仓 |
| 纽伯格伯曼集团Neuberger Berman Group LLC |
| 0.01% | <0.01% | #67 | $1,270.0万 | 8.3万股 | $612.1万 | 4.9万股 | +3.4万股+69.25% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #91 | $1,130.8万 | 7.4万股 | $807.5万 | 6.5万股 | +9,212股+14.22% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #113 | $1,108.3万 | 7.3万股 | $1,303.1万 | 10.5万股 | -3.2万股-30.62% | 减仓 |
| Avidity Partners Management LP |
| 1.71% | 1.77% | #10 | $1,069.7万 | 7.0万股 | $872.6万 | 7.0万股 | 00.00% | 持仓不变 |
| AWM Investment Company, Inc. |
| 0.92% | 0.96% | #13 | $1,060.8万 | 6.9万股 | $865.3万 | 6.9万股 | 00.00% | 持仓不变 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #99 | $1,031.1万 | 6.7万股 | $871.3万 | 7.0万股 | -2,432股-3.48% | 减仓 |
| SEVEN GRAND MANAGERS, LLC |
| 0.37% | 0.5% | #24 | $916.9万 | 6.0万股 | $747.9万 | 6.0万股 | 00.00% | 持仓不变 |
| 清水投资Clearbridge Investments, LLC |
| 0.01% | 0.01% | #69 | $906.8万 | 5.9万股 | $740.5万 | 5.9万股 | -69股-0.12% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #139 | $833.7万 | 5.5万股 | $473.3万 | 3.8万股 | +1.7万股+43.67% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | <0.01% | #60 | $814.1万 | 5.3万股 | $224.0万 | 1.8万股 | +3.5万股+196.44% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #87 | $797.9万 | 5.2万股 | $1,167.3万 | 9.4万股 | -4.1万股-44.25% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | 0.01% | #56 | $789.5万 | 5.2万股 | $488.9万 | 3.9万股 | +1.2万股+31.71% | 加仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | — | #82 | $764.1万 | 5.0万股 | $0 | 0股 | +5.0万股 | 新买入 |
| Nicholas Investment Partners, LP |
| 0.43% | 0.25% | #22 | $759.8万 | 5.0万股 | $344.1万 | 2.8万股 | +2.2万股+80.12% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #129 | $721.6万 | 4.7万股 | $703.9万 | 5.6万股 | -9,252股-16.38% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.02% | #66 | $680.6万 | 4.5万股 | $1,205.7万 | 9.7万股 | -5.2万股-53.96% | 减仓 |
| Lisanti Capital Growth, LLC |
| 1.44% | 1.3% | #11 | $656.7万 | 4.3万股 | $516.6万 | 4.1万股 | +1,530股+3.69% | 加仓 |
