| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.45% | 0.38% | #31 | $6.87亿 | 3,091.2万股 | $5.58亿 | 3,078.6万股 | +12.6万股+0.41% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #102 | $2.76亿 | 1,240.4万股 | $2.12亿 | 1,170.0万股 | +70.4万股+6.02% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.11% | — | #41 | $2.67亿 | 1,199.8万股 | $0 | 0股 | +1,199.8万股 | 新买入 |
| 富达投资FMR LLC |
| 0.01% | 0.01% | #74 | $2.49亿 | 1,120.7万股 | $1.62亿 | 890.9万股 | +229.8万股+25.79% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #95 | $1.66亿 | 745.8万股 | $1.21亿 | 665.4万股 | +80.5万股+12.09% | 加仓 |
| Orbis Allan GrayOrbis Allan Gray Ltd |
| 0.53% | 0.52% | #29 | $1.56亿 | 700.7万股 | $1.23亿 | 676.2万股 | +24.4万股+3.61% | 加仓 |
| Atlas Venture Life Science Advisors, LLC |
| 17.14% | 20.95% | #1 | $1.51亿 | 680.0万股 | $1.66亿 | 913.0万股 | -233.0万股-25.52% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #118 | $1.40亿 | 631.1万股 | $1.16亿 | 640.5万股 | -9.4万股-1.47% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 2.46% | 2.39% | #8 | $1.03亿 | 461.5万股 | $8,367.3万 | 461.5万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #103 | $8,991.6万 | 404.8万股 | $7,545.8万 | 416.2万股 | -11.4万股-2.73% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #84 | $8,743.6万 | 393.7万股 | $4,221.5万 | 232.8万股 | +160.8万股+69.08% | 加仓 |
| FCPM III SERVICES B.V. |
| 11.39% | 11.66% | #2 | $8,547.0万 | 384.8万股 | $8,420.3万 | 464.4万股 | -79.6万股-17.14% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #100 | $8,315.9万 | 374.3万股 | $6,354.3万 | 350.4万股 | +23.9万股+6.83% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 1.75% | 2.03% | #12 | $7,495.9万 | 337.5万股 | $7,252.0万 | 400.0万股 | -62.5万股-15.63% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.36% | 1.05% | #16 | $7,186.5万 | 323.6万股 | $5,290.1万 | 291.8万股 | +31.8万股+10.89% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 1.53% | 1.47% | #14 | $7,003.0万 | 315.3万股 | $5,716.5万 | 315.3万股 | 00.00% | 持仓不变 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.84% | 1.02% | #25 | $6,856.7万 | 308.7万股 | $5,756.5万 | 317.5万股 | -8.8万股-2.77% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #104 | $6,715.4万 | 315.2万股 | $5,560.2万 | 325.3万股 | -10.2万股-3.13% | 减仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.9% | 1.65% | #23 | $5,972.8万 | 268.9万股 | $8,464.6万 | 466.9万股 | -198.0万股-42.40% | 减仓 |
| Logos Global Management LP |
| 2.44% | 1.27% | #9 | $5,663.6万 | 255.0万股 | $2,538.2万 | 140.0万股 | +115.0万股+82.14% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #114 | $4,960.4万 | 223.3万股 | $2,616.7万 | 144.3万股 | +79.0万股+54.74% | 加仓 |
| Venrock Adviser, LLC |
| 1.46% | 1.47% | #15 | $4,828.3万 | 217.4万股 | $3,941.3万 | 217.4万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #101 | $4,791.1万 | 215.7万股 | $3,124.0万 | 172.3万股 | +43.4万股+25.19% | 加仓 |
| Siren, L.L.C. |
| 0.96% | 1.12% | #21 | $4,728.8万 | 212.9万股 | $4,041.4万 | 222.9万股 | -10.0万股-4.49% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #82 | $4,510.4万 | 203.1万股 | $3,642.5万 | 200.9万股 | +2.2万股+1.08% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #87 | $4,322.2万 | 194.6万股 | $1,724.4万 | 95.2万股 | +99.5万股+104.55% | 加仓 |
| MPM BioImpact LLC |
| 2.6% | 1.97% | #7 | $4,269.0万 | 192.2万股 | $2,553.0万 | 140.8万股 | +51.4万股+36.50% | 加仓 |
| 萨姆林资本SAMLYN CAPITAL, LLC |
| 0.63% | 0.59% | #27 | $3,897.2万 | 175.5万股 | $3,485.6万 | 192.3万股 | -16.8万股-8.73% | 减仓 |
| Sofinnova Investments, Inc. |
| 1.9% | 1.13% | #11 | $3,683.3万 | 165.8万股 | $2,962.3万 | 163.4万股 | +2.4万股+1.50% | 加仓 |
| Palo Alto Investors LP |
| 5.35% | 4.58% | #4 | $3,659.1万 | 164.8万股 | $2,996.8万 | 165.3万股 | -5,451股-0.33% | 减仓 |
| Vivo Capital, LLC |
| 3.16% | 2.35% | #6 | $3,459.1万 | 155.7万股 | $2,823.7万 | 155.7万股 | 00.00% | 持仓不变 |
| 安本标准投资Aberdeen Group plc |
| 0.05% | 0.04% | #55 | $3,419.1万 | 153.9万股 | $2,593.3万 | 143.0万股 | +10.9万股+7.62% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.48% | 0.59% | #30 | $3,331.5万 | 150.0万股 | $3,626.0万 | 200.0万股 | -50.0万股-25.00% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.03% | <0.01% | #64 | $3,306.9万 | 148.9万股 | $150.7万 | 8.3万股 | +140.6万股+1,690.70% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.07% | 0.09% | #49 | $2,858.0万 | 128.7万股 | $2,464.2万 | 135.9万股 | -7.2万股-5.32% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #112 | $2,838.6万 | 127.8万股 | $2,173.5万 | 119.9万股 | +7.9万股+6.61% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #107 | $2,670.1万 | 120.2万股 | $2,100.2万 | 115.8万股 | +4.4万股+3.78% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #117 | $2,637.3万 | 118.7万股 | $436.1万 | 24.1万股 | +94.7万股+393.66% | 加仓 |
| Saturn V Capital Management LP |
| 3.37% | 3.17% | #5 | $2,348.7万 | 105.7万股 | $1,752.5万 | 96.7万股 | +9.1万股+9.40% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #96 | $2,196.5万 | 98.9万股 | $1,717.7万 | 94.7万股 | +4.2万股+4.38% | 加仓 |
| Novo Holdings A/S |
| 1.24% | — | #18 | $2,133.0万 | 96.0万股 | $0 | 0股 | +96.0万股 | 新买入 |
| Rock Springs Capital Management LP |
| 1.02% | 1.04% | #20 | $2,092.5万 | 94.2万股 | $1,762.6万 | 97.2万股 | -3.0万股-3.09% | 减仓 |
| BRAIDWELL LP |
| 0.76% | 1.02% | #26 | $2,046.9万 | 92.2万股 | $3,049.5万 | 168.2万股 | -76.0万股-45.21% | 减仓 |
| Frontier资本管理FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.18% | 0.15% | #36 | $1,941.5万 | 87.4万股 | $1,490.0万 | 82.2万股 | +5.2万股+6.36% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.09% | 0.08% | #44 | $1,806.7万 | 81.3万股 | $1,474.8万 | 81.3万股 | 00.00% | 持仓不变 |
| Fiera资本Fiera Capital Corp |
| 0.06% | 0.09% | #51 | $1,754.6万 | 79.0万股 | $2,503.1万 | 138.1万股 | -59.1万股-42.78% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #162 | $1,657.3万 | 74.6万股 | $1,795.0万 | 141.9万股 | -67.3万股-47.41% | 减仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.02% | 0.02% | #66 | $1,465.4万 | 66.0万股 | $1,123.1万 | 61.9万股 | +4.0万股+6.51% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #109 | $1,280.1万 | 57.6万股 | $818.8万 | 45.2万股 | +12.5万股+27.61% | 加仓 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #77 | $1,217.4万 | 54.8万股 | $959.6万 | 52.9万股 | +1.9万股+3.55% | 加仓 |
