| 富达投资FMR LLC |
| 0.01% | 0.02% | #70 | $3.05亿 | 1,660.5万股 | $3.01亿 | 1,537.9万股 | +122.5万股+7.97% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #110 | $1.57亿 | 855.1万股 | $1.53亿 | 783.1万股 | +72.0万股+9.19% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 2.6% | 3.13% | #6 | $1.24亿 | 673.2万股 | $1.32亿 | 672.6万股 | +5,765股+0.09% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 2.31% | 1.26% | #8 | $1.24亿 | 672.4万股 | $6,159.2万 | 314.9万股 | +357.5万股+113.53% | 加仓 |
| Kynam Capital Management, LP |
| 6.55% | 2.83% | #1 | $1.19亿 | 645.4万股 | $4,580.3万 | 234.2万股 | +411.2万股+175.61% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #101 | $1.13亿 | 612.5万股 | $9,140.2万 | 467.3万股 | +145.2万股+31.07% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #71 | $1.06亿 | 574.8万股 | $6,271.1万 | 320.6万股 | +254.2万股+79.30% | 加仓 |
| Fairmount Funds Management LLC |
| 6.18% | 5.53% | #2 | $9,352.0万 | 509.1万股 | $7,656.7万 | 391.4万股 | +117.6万股+30.05% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #122 | $8,407.7万 | 457.7万股 | $8,151.0万 | 416.7万股 | +41.0万股+9.83% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.96% | 0.45% | #16 | $6,599.9万 | 359.3万股 | $2,726.6万 | 139.4万股 | +219.9万股+157.74% | 加仓 |
| Venrock Adviser, LLC |
| 1.81% | 2.83% | #11 | $5,984.8万 | 325.8万股 | $7,594.6万 | 388.3万股 | -62.5万股-16.09% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #75 | $5,746.8万 | 312.8万股 | $6,021.7万 | 307.9万股 | +5.0万股+1.62% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #111 | $5,056.9万 | 275.3万股 | $3,210.7万 | 164.1万股 | +111.1万股+67.70% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $4,596.8万 | 250.2万股 | $4,564.6万 | 233.3万股 | +16.9万股+7.23% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 0.41% | 0.29% | #23 | $4,592.5万 | 250.0万股 | $2,934.0万 | 150.0万股 | +100.0万股+66.67% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.22% | 0.22% | #29 | $4,377.6万 | 238.3万股 | $3,856.6万 | 197.2万股 | +41.1万股+20.86% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.05% | 0.01% | #53 | $4,328.4万 | 235.6万股 | $631.5万 | 32.3万股 | +203.3万股+629.85% | 加仓 |
| Caligan Partners LP |
| 1.9% | — | #10 | $4,030.3万 | 219.4万股 | $0 | 0股 | +219.4万股 | 新买入 |
| Novo Holdings A/S |
| 2.28% | 3.17% | #9 | $3,922.0万 | 213.5万股 | $3,912.0万 | 200.0万股 | +13.5万股+6.75% | 加仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 1.5% | 1.78% | #14 | $3,293.1万 | 179.3万股 | $3,506.4万 | 179.3万股 | 00.00% | 持仓不变 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.01% | 0.01% | #77 | $3,216.3万 | 175.1万股 | $3,458.8万 | 176.8万股 | -1.7万股-0.99% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.14% | 0.12% | #34 | $3,134.0万 | 170.8万股 | $2,443.3万 | 78.5万股 | +92.3万股+117.51% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #103 | $3,106.9万 | 169.1万股 | $3,113.8万 | 159.2万股 | +9.9万股+6.24% | 加仓 |
| First Turn Management, LLC |
| 3.28% | 1.99% | #4 | $3,067.8万 | 167.0万股 | $1,782.6万 | 91.1万股 | +75.9万股+83.25% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #85 | $2,960.7万 | 161.2万股 | $1,035.5万 | 53.0万股 | +108.2万股+204.20% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #78 | $2,722.0万 | 139.2万股 | $4,332.1万 | 139.2万股 | -433股-0.03% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #99 | $2,624.8万 | 142.9万股 | $600.8万 | 30.7万股 | +112.2万股+365.22% | 加仓 |
| Parkman Healthcare Partners LLC |
| 2.59% | 1.13% | #7 | $2,530.6万 | 137.8万股 | $1,091.3万 | 55.8万股 | +82.0万股+146.91% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.06% | #61 | $2,351.1万 | 128.0万股 | $4,530.0万 | 231.6万股 | -103.6万股-44.74% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #72 | $2,171.7万 | 118.2万股 | $2,469.5万 | 126.3万股 | -8.0万股-6.36% | 减仓 |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 1.05% | 0.98% | #15 | $2,160.1万 | 117.6万股 | $1,757.7万 | 89.9万股 | +27.7万股+30.86% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | <0.01% | #79 | $2,043.5万 | 111.2万股 | $45.5万 | 2.3万股 | +108.9万股+4,678.61% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #80 | $1,859.3万 | 101.2万股 | $521.1万 | 26.6万股 | +74.6万股+279.93% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #100 | $1,836.8万 | 100.0万股 | $1,737.5万 | 88.8万股 | +11.2万股+12.57% | 加仓 |
| Elmind Capital, LP |
| 4.55% | 2.97% | #3 | $1,809.3万 | 98.5万股 | $1,046.3万 | 53.5万股 | +45.0万股+84.12% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #135 | $1,734.8万 | 94.4万股 | $2,276.0万 | 116.4万股 | -21.9万股-18.84% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #119 | $1,586.2万 | 86.3万股 | $1,363.3万 | 69.7万股 | +16.6万股+23.89% | 加仓 |
| Eversept Partners, LP |
| 0.79% | 0.74% | #18 | $1,526.8万 | 83.1万股 | $1,395.2万 | 71.3万股 | +11.8万股+16.53% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #116 | $1,497.2万 | 81.5万股 | $1,423.8万 | 72.8万股 | +8.7万股+11.96% | 加仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.05% | — | #50 | $1,457.7万 | 79.4万股 | $0 | 0股 | +79.4万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.01% | #65 | $1,411.9万 | 76.9万股 | $397.3万 | 20.3万股 | +56.6万股+278.43% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #150 | $1,338.8万 | 72.9万股 | $414.2万 | 19.2万股 | +53.7万股+279.71% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.04% | 0.05% | #56 | $1,287.6万 | 70.1万股 | $1,371.0万 | 70.1万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #153 | $1,210.6万 | 64.0万股 | $1,963.9万 | 106.0万股 | -42.0万股-39.62% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #104 | $1,208.0万 | 65.8万股 | $1,156.4万 | 59.1万股 | +6.6万股+11.22% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.16% | 0.45% | #32 | $1,069.1万 | 58.2万股 | $2,290.1万 | 117.1万股 | -58.9万股-50.29% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.13% | — | #35 | $993.9万 | 54.1万股 | $0 | 0股 | +54.1万股 | 新买入 |
| EMERALD ADVISERS, LLC |
| 0.23% | — | #27 | $987.1万 | 53.7万股 | $0 | 0股 | +53.7万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | 0.01% | #105 | $887.0万 | 48.3万股 | $2,019.2万 | 103.2万股 | -54.9万股-53.22% | 减仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.11% | 0.17% | #42 | $885.9万 | 48.2万股 | $1,103.2万 | 56.4万股 | -8.2万股-14.50% | 减仓 |
