| 富达投资FMR LLC |
| 0.01% | 0.01% | #73 | $3.23亿 | 3,284.4万股 | $2.77亿 | 3,265.4万股 | +19.0万股+0.58% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 2.81% | 2.72% | #6 | $1.93亿 | 1,968.6万股 | $1.67亿 | 1,968.6万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #116 | $1.90亿 | 1,937.7万股 | $1.37亿 | 1,613.3万股 | +324.4万股+20.11% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 1.11% | 1.03% | #15 | $1.23亿 | 1,254.0万股 | $1.04亿 | 1,231.5万股 | +22.5万股+1.83% | 加仓 |
| SUMMER ROAD LLC |
| 74.46% | 70.84% | #1 | $1.20亿 | 1,220.8万股 | $1.01亿 | 1,188.0万股 | +32.8万股+2.76% | 加仓 |
| Venrock Adviser, LLC |
| 3.08% | 3.27% | #5 | $1.02亿 | 1,034.7万股 | $8,763.8万 | 1,034.7万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #137 | $8,673.6万 | 883.3万股 | $7,385.0万 | 871.9万股 | +11.4万股+1.30% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #91 | $7,486.3万 | 762.4万股 | $4,995.0万 | 589.7万股 | +172.6万股+29.27% | 加仓 |
| Logos Global Management LP |
| 2.24% | 1.63% | #7 | $5,204.6万 | 530.0万股 | $3,261.0万 | 385.0万股 | +145.0万股+37.66% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #145 | $5,139.1万 | 523.3万股 | $3,988.0万 | 470.8万股 | +52.5万股+11.15% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #120 | $4,931.5万 | 502.1万股 | $3,836.9万 | 452.9万股 | +49.2万股+10.86% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.04% | 0.06% | #53 | $3,232.9万 | 329.2万股 | $4,688.1万 | 553.5万股 | -224.3万股-40.52% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.04% | 0.03% | #51 | $3,187.5万 | 324.6万股 | $2,280.7万 | 269.3万股 | +55.3万股+20.55% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #98 | $2,733.4万 | 278.3万股 | $549.1万 | 65.0万股 | +213.4万股+328.37% | 加仓 |
| DELTEC ASSET MANAGEMENT LLC |
| 3.59% | 3.64% | #4 | $2,431.6万 | 247.6万股 | $1,982.5万 | 234.1万股 | +13.6万股+5.79% | 加仓 |
| Octagon Capital Advisors LP |
| 1.83% | 2.97% | #12 | $2,037.7万 | 207.5万股 | $2,682.1万 | 316.7万股 | -109.2万股-34.47% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #170 | $1,937.6万 | 197.3万股 | $1,350.7万 | 159.5万股 | +37.8万股+23.73% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #129 | $1,767.0万 | 179.9万股 | $1,292.2万 | 152.6万股 | +27.4万股+17.95% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #146 | $1,730.0万 | 176.2万股 | $940.5万 | 111.0万股 | +65.1万股+58.66% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #107 | $1,666.7万 | 169.7万股 | $348.2万 | 41.1万股 | +128.6万股+312.88% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.05% | 0.05% | #42 | $1,637.6万 | 166.8万股 | $1,412.5万 | 166.8万股 | 00.00% | 持仓不变 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.39% | 0.4% | #26 | $1,618.1万 | 164.8万股 | $1,395.6万 | 164.8万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #134 | $1,523.1万 | 155.1万股 | $1,288.0万 | 152.1万股 | +3.0万股+2.00% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | — | #64 | $1,522.1万 | 155.0万股 | $0 | 0股 | +155.0万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #131 | $1,505.8万 | 153.3万股 | $1,237.6万 | 146.1万股 | +7.2万股+4.95% | 加仓 |
| Defilade Capital Management, L.P. |
| 1.96% | 1.77% | #9 | $1,463.5万 | 149.0万股 | $1,260.0万 | 148.8万股 | +2,641股+0.18% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.02% | 0.01% | #71 | $1,390.4万 | 141.6万股 | $830.7万 | 98.1万股 | +43.5万股+44.37% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #163 | $1,320.2万 | 134.4万股 | $1,301.7万 | 153.7万股 | -19.2万股-12.52% | 减仓 |
| Boxer Capital Management, LLC |
| 0.96% | 0.39% | #17 | $1,276.6万 | 130.0万股 | $296.5万 | 35.0万股 | +95.0万股+271.43% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #117 | $1,266.0万 | 128.9万股 | $1,054.5万 | 124.5万股 | +4.4万股+3.55% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #85 | $1,196.6万 | 121.9万股 | $1,550.1万 | 183.0万股 | -61.2万股-33.42% | 减仓 |
| Knoll Capital Management, LLC |
| 6.48% | 2.69% | #2 | $1,129.7万 | 115.0万股 | $508.5万 | 60.0万股 | +55.0万股+91.61% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #169 | $1,124.1万 | 114.5万股 | $656.9万 | 77.6万股 | +36.9万股+47.60% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| 0.02% | 0.02% | #68 | $1,057.7万 | 107.7万股 | $600.7万 | 70.9万股 | +36.8万股+51.87% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #121 | $946.0万 | 96.3万股 | $728.0万 | 85.9万股 | +10.4万股+12.08% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #113 | $933.2万 | 95.0万股 | $422.9万 | 49.9万股 | +45.1万股+90.32% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #198 | $895.4万 | 91.2万股 | $2,882.4万 | 246.6万股 | -155.4万股-63.02% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.04% | 0.05% | #49 | $890.6万 | 90.8万股 | $1,021.7万 | 84.2万股 | +6.6万股+7.87% | 加仓 |
| Empire Life Investments Inc. |
| 0.48% | 0.45% | #24 | $856.0万 | 87.2万股 | $736.6万 | 88.4万股 | -1.3万股-1.43% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #166 | $800.9万 | 81.6万股 | $956.0万 | 112.9万股 | -31.3万股-27.74% | 减仓 |
| Cetera投资顾问Cetera Investment Advisers |
| 0.01% | 0.01% | #92 | $771.6万 | 78.6万股 | $647.6万 | 76.5万股 | +2.1万股+2.76% | 加仓 |
| READYSTATE 资产管理READYSTATE ASSET MANAGEMENT LP |
| 0.38% | 0.34% | #27 | $748.4万 | 88.4万股 | $748.4万 | 88.4万股 | 00.00% | 持仓不变 |
| PEREGRINE 资本管理PEREGRINE CAPITAL MANAGEMENT LLC |
| 0.24% | 0.23% | #29 | $739.9万 | 75.3万股 | $610.2万 | 72.0万股 | +3.3万股+4.58% | 加仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.01% | 0.02% | #81 | $681.6万 | 69.4万股 | $1,318.3万 | 155.6万股 | -86.2万股-55.41% | 减仓 |
| Aptus资本顾问Aptus Capital Advisors, LLC |
| 0.04% | 0.04% | #46 | $627.2万 | 63.9万股 | $448.7万 | 53.0万股 | +10.9万股+20.56% | 加仓 |
| Second Line Capital, LLC |
| 1.17% | 0.94% | #14 | $627.1万 | 63.9万股 | $495.0万 | 52.8万股 | +11.0万股+20.89% | 加仓 |
| Opaleye Management Inc. |
| 0.53% | 0.67% | #23 | $589.2万 | 60.0万股 | $508.2万 | 60.0万股 | 00.00% | 持仓不变 |
| Algert全球ALGERT GLOBAL LLC |
| 0.07% | 0.07% | #41 | $581.6万 | 59.2万股 | $456.5万 | 53.9万股 | +5.3万股+9.90% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #167 | $543.3万 | 55.3万股 | $403.2万 | 47.6万股 | +7.7万股+16.23% | 加仓 |
| 英仕曼集团Man Group plc |
| 0.01% | <0.01% | #86 | $533.8万 | 54.4万股 | $150.3万 | 17.7万股 | +36.6万股+206.30% | 加仓 |
