| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 9.96% | 10.27% | #2 | $4.58亿 | 2,497.5万股 | $3.99亿 | 2,467.5万股 | +30.0万股+1.22% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.25% | 0.24% | #38 | $3.88亿 | 2,118.6万股 | $3.44亿 | 2,126.0万股 | -7.4万股-0.35% | 减仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #111 | $3.88亿 | 2,115.4万股 | $3.26亿 | 2,015.1万股 | +100.3万股+4.98% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 2.81% | 2.6% | #14 | $3.29亿 | 1,794.7万股 | $2.61亿 | 1,615.7万股 | +179.0万股+11.08% | 加仓 |
| Venrock Adviser, LLC |
| 9.94% | 9.89% | #3 | $3.28亿 | 1,789.2万股 | $2.65亿 | 1,638.3万股 | +150.9万股+9.21% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #100 | $2.23亿 | 1,218.5万股 | $1.50亿 | 930.0万股 | +288.4万股+31.02% | 加仓 |
| Logos Global Management LP |
| 9.58% | 9.01% | #4 | $2.23亿 | 1,215.0万股 | $1.80亿 | 1,115.0万股 | +100.0万股+8.97% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #128 | $2.09亿 | 1,140.2万股 | $1.82亿 | 1,125.0万股 | +15.2万股+1.36% | 加仓 |
| Siren, L.L.C. |
| 4.23% | 5.04% | #9 | $2.09亿 | 1,139.8万股 | $1.82亿 | 1,124.4万股 | +15.4万股+1.37% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 3.28% | 3.44% | #13 | $1.75亿 | 955.0万股 | $1.68亿 | 1,039.3万股 | -84.3万股-8.11% | 减仓 |
| ARCH Venture Management, LLC |
| 11.81% | 16.95% | #1 | $1.30亿 | 709.2万股 | $1.15亿 | 709.2万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #103 | $1.19亿 | 650.1万股 | $9,703.7万 | 599.6万股 | +50.5万股+8.43% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #79 | $1.15亿 | 627.3万股 | $2,937.4万 | 181.5万股 | +445.7万股+245.53% | 加仓 |
| Cormorant Asset Management, LP |
| 5.58% | 4.71% | #7 | $1.10亿 | 600.0万股 | $9,384.4万 | 580.0万股 | +20.0万股+3.45% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.47% | 0.06% | #29 | $1.01亿 | 550.5万股 | $991.0万 | 61.3万股 | +489.3万股+798.81% | 加仓 |
| Affinity Asset Advisors, LLC |
| 4.35% | 4.47% | #8 | $9,618.0万 | 525.0万股 | $8,656.3万 | 535.0万股 | -10.0万股-1.87% | 减仓 |
| Vivo Capital, LLC |
| 6.9% | 16.34% | #5 | $7,561.4万 | 412.7万股 | $1.97亿 | 1,215.1万股 | -802.4万股-66.03% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #105 | $7,002.1万 | 382.2万股 | $7,888.1万 | 487.5万股 | -105.3万股-21.60% | 减仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.02% | <0.01% | #71 | $6,663.9万 | 411.9万股 | $983.9万 | 264.5万股 | +147.4万股+55.72% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #140 | $5,585.3万 | 304.9万股 | $4,944.4万 | 305.6万股 | -7,160股-0.23% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #157 | $5,282.4万 | 288.3万股 | $2,410.9万 | 149.0万股 | +139.3万股+93.51% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.16% | 0.17% | #43 | $5,188.0万 | 283.2万股 | $4,581.4万 | 283.2万股 | +329股+0.01% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.03% | — | #65 | $5,108.4万 | 278.8万股 | $0 | 0股 | +278.8万股 | 新买入 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 1.7% | — | #18 | $4,946.4万 | 270.0万股 | $0 | 0股 | +270.0万股 | 新买入 |
| a16z资本管理a16z Capital Management, L.L.C. |
| 3.69% | 3.59% | #11 | $4,631.5万 | 286.3万股 | $4,631.5万 | 286.3万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #165 | $4,378.2万 | 239.0万股 | $2,869.9万 | 177.4万股 | +61.6万股+34.73% | 加仓 |
| 萨姆林资本SAMLYN CAPITAL, LLC |
| 0.67% | — | #23 | $4,134.8万 | 225.7万股 | $0 | 0股 | +225.7万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #76 | $3,741.0万 | 204.2万股 | $1,759.3万 | 108.7万股 | +95.5万股+87.81% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #134 | $3,587.3万 | 195.8万股 | $2,753.2万 | 170.2万股 | +25.6万股+15.07% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #126 | $3,562.9万 | 194.5万股 | $3,071.3万 | 189.8万股 | +4.7万股+2.45% | 加仓 |
| 胜利资本管理VICTORY CAPITAL MANAGEMENT INC |
| 0.02% | 0.02% | #73 | $3,547.6万 | 193.6万股 | $2,677.0万 | 165.4万股 | +28.2万股+17.04% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #90 | $3,374.1万 | 184.2万股 | $878.6万 | 54.3万股 | +129.9万股+239.16% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #154 | $3,285.7万 | 179.3万股 | $2,392.3万 | 147.9万股 | +31.5万股+21.30% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #108 | $3,231.5万 | 176.4万股 | $2,887.3万 | 178.6万股 | -2.2万股-1.25% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #98 | $3,110.7万 | 169.8万股 | $2,488.3万 | 153.8万股 | +16.0万股+10.41% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #138 | $2,925.1万 | 159.7万股 | $2,991.0万 | 184.9万股 | -25.2万股-13.63% | 减仓 |
| STEMPOINT CAPITAL LP |
| 4.1% | 0.72% | #10 | $2,877.8万 | 176.6万股 | $388.1万 | 24.0万股 | +152.6万股+636.22% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #159 | $2,715.0万 | 148.2万股 | $999.3万 | 61.8万股 | +86.4万股+139.95% | 加仓 |
| Rock Springs Capital Management LP |
| 1.25% | 1.05% | #20 | $2,568.7万 | 140.2万股 | $1,785.4万 | 110.3万股 | +29.9万股+27.07% | 加仓 |
| 长青优质基金Evergreen Quality Fund GP, Ltd. |
| 0.41% | — | #31 | $2,519.5万 | 137.5万股 | $0 | 0股 | +137.5万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | 0.04% | #64 | $2,507.9万 | 136.9万股 | $2,263.4万 | 139.9万股 | -3.0万股-2.14% | 减仓 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.08% | 0.02% | #53 | $2,397.1万 | 130.8万股 | $383.2万 | 23.7万股 | +107.2万股+452.50% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.4% | 3.06% | #15 | $2,313.9万 | 126.3万股 | $2,996.2万 | 185.2万股 | -58.9万股-31.80% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.11% | #67 | $2,305.0万 | 125.8万股 | $8,323.0万 | 514.4万股 | -388.6万股-75.54% | 减仓 |
| Octagon Capital Advisors LP |
| 2.07% | — | #17 | $2,299.2万 | 125.5万股 | $0 | 0股 | +125.5万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.03% | 0.01% | #70 | $2,284.9万 | 124.7万股 | $1,121.8万 | 69.3万股 | +55.4万股+79.89% | 加仓 |
| First Turn Management, LLC |
| 2.39% | 1.57% | #16 | $2,238.2万 | 122.2万股 | $1,403.8万 | 86.8万股 | +35.4万股+40.81% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.03% | <0.01% | #69 | $1,982.7万 | 108.2万股 | $1.6万 | 1,005股 | +108.1万股+107,587.76% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 0.72% | 0.54% | #22 | $1,832.0万 | 100.0万股 | $1,132.6万 | 70.0万股 | +30.0万股+42.86% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #88 | $1,739.6万 | 95.0万股 | $1,973.2万 | 122.0万股 | -27.0万股-22.14% | 减仓 |
