| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #101 | $2.40亿 | 645.6万股 | $1.95亿 | 575.5万股 | +70.1万股+12.18% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 1.01% | 1.1% | #12 | $2.20亿 | 591.7万股 | $1.92亿 | 568.4万股 | +23.3万股+4.11% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 2.37% | 3.56% | #6 | $1.93亿 | 521.0万股 | $2.00亿 | 591.6万股 | -70.6万股-11.93% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #97 | $1.31亿 | 353.4万股 | $1.14亿 | 336.5万股 | +16.9万股+5.02% | 加仓 |
| Lynx1 Capital Management LP |
| 24.92% | 13.96% | #1 | $1.27亿 | 340.9万股 | $8,834.9万 | 261.2万股 | +79.7万股+30.53% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.05% | 0.05% | #37 | $1.15亿 | 310.7万股 | $9,070.4万 | 268.1万股 | +42.6万股+15.88% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #89 | $1.08亿 | 289.8万股 | $8,833.1万 | 261.1万股 | +28.7万股+11.00% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #126 | $9,952.3万 | 268.2万股 | $8,905.1万 | 263.2万股 | +5.0万股+1.88% | 加仓 |
| 奥地利Erste资产管理Erste Asset Management GmbH |
| 0.64% | 0.74% | #14 | $8,197.2万 | 215.5万股 | $8,009.2万 | 270.5万股 | -55.0万股-20.33% | 减仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.12% | 0.09% | #26 | $7,833.2万 | 211.1万股 | $5,055.7万 | 149.4万股 | +61.6万股+41.24% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | 0.01% | #87 | $6,246.2万 | 168.3万股 | $5,265.1万 | 155.6万股 | +12.7万股+8.15% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #108 | $5,843.3万 | 157.4万股 | $4,967.0万 | 146.8万股 | +10.6万股+7.25% | 加仓 |
| ADAR1 Capital Management, LLC |
| 2.2% | 0.28% | #7 | $4,780.0万 | 128.8万股 | $475.9万 | 14.1万股 | +114.7万股+815.64% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.05% | — | #42 | $4,750.2万 | 128.0万股 | $0 | 0股 | +128.0万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #74 | $4,634.5万 | 124.9万股 | $3,894.0万 | 115.2万股 | +9.7万股+8.43% | 加仓 |
| GW&K Investment Management, LLC |
| 0.35% | 0.36% | #16 | $4,477.7万 | 120.7万股 | $4,110.1万 | 121.5万股 | -8,286股-0.68% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #99 | $4,271.1万 | 115.1万股 | $2,766.2万 | 81.8万股 | +33.3万股+40.76% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #93 | $3,658.4万 | 98.6万股 | $448.4万 | 13.3万股 | +85.3万股+643.80% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #133 | $3,574.6万 | 96.3万股 | $1,673.8万 | 41.7万股 | +54.6万股+131.00% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #98 | $3,388.8万 | 91.3万股 | $2,602.9万 | 76.9万股 | +14.4万股+18.69% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | 0.01% | #75 | $3,241.8万 | 87.4万股 | $2,443.7万 | 72.2万股 | +15.1万股+20.93% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | <0.01% | #66 | $3,007.9万 | 81.1万股 | $847.3万 | 25.0万股 | +56.0万股+223.62% | 加仓 |
| Foresite Capital Management VI LLC |
| 4.53% | 3.86% | #2 | $2,913.1万 | 78.5万股 | $1,776.1万 | 52.5万股 | +26.0万股+49.52% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #119 | $2,770.6万 | 74.7万股 | $2,846.6万 | 84.1万股 | -9.5万股-11.27% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #73 | $2,539.6万 | 68.4万股 | $123.2万 | 3.6万股 | +64.8万股+1,779.54% | 加仓 |
| Parkman Healthcare Partners LLC |
| 2.54% | 1.41% | #5 | $2,482.8万 | 66.9万股 | $1,365.1万 | 40.4万股 | +26.6万股+65.80% | 加仓 |
| SCS资本管理SCS Capital Management LLC |
| 0.21% | 0.22% | #21 | $2,274.3万 | 61.3万股 | $2,073.3万 | 61.3万股 | 00.00% | 持仓不变 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.02% | 0.01% | #54 | $2,217.8万 | 59.8万股 | $634.9万 | 18.8万股 | +41.0万股+218.46% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #118 | $2,058.5万 | 55.5万股 | $1,722.9万 | 50.9万股 | +4.5万股+8.92% | 加仓 |
| Defilade Capital Management, L.P. |
| 2.72% | — | #4 | $2,029.4万 | 54.7万股 | $0 | 0股 | +54.7万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #114 | $1,997.0万 | 53.8万股 | $1,613.8万 | 47.7万股 | +6.1万股+12.81% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #62 | $1,990.5万 | 53.6万股 | $851.3万 | 25.2万股 | +28.5万股+113.16% | 加仓 |
| Rock Springs Capital Management LP |
| 0.96% | 1.59% | #13 | $1,976.3万 | 53.3万股 | $2,703.6万 | 79.9万股 | -26.7万股-33.36% | 减仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.07% | 0.05% | #34 | $1,930.0万 | 52.0万股 | $676.8万 | 20.0万股 | +32.0万股+159.96% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #149 | $1,884.7万 | 50.8万股 | $1,718.2万 | 50.8万股 | -31股-0.01% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.02% | <0.01% | #53 | $1,879.0万 | 50.6万股 | $99.5万 | 2.9万股 | +47.7万股+1,622.26% | 加仓 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | <0.01% | #104 | $1,613.2万 | 43.5万股 | $1,434.1万 | 42.4万股 | +1.1万股+2.55% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #107 | $1,469.1万 | 39.6万股 | $1,292.4万 | 38.2万股 | +1.4万股+3.62% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.04% | 0.03% | #43 | $1,387.7万 | 37.4万股 | $806.7万 | 23.8万股 | +13.5万股+56.81% | 加仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.25% | 0.2% | #20 | $1,385.1万 | 37.3万股 | $931.9万 | 27.5万股 | +9.8万股+35.50% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #165 | $1,378.4万 | 36.0万股 | $448.8万 | 15.2万股 | +20.8万股+137.37% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.03% | 0.04% | #50 | $1,334.3万 | 36.0万股 | $1,522.7万 | 45.0万股 | -9.1万股-20.12% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| 0.01% | 0.01% | #67 | $1,191.7万 | 32.1万股 | $706.7万 | 20.9万股 | +11.2万股+53.74% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.02% | <0.01% | #57 | $1,104.5万 | 29.8万股 | $22.2万 | 6,570股 | +29.1万股+4,430.14% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | 0.01% | #91 | $999.7万 | 26.9万股 | $1,107.8万 | 32.7万股 | -5.8万股-17.73% | 减仓 |
| Tetragon Partners GP Ltd |
| 1.49% | 1.08% | #10 | $948.5万 | 25.6万股 | $557.7万 | 16.5万股 | +9.1万股+55.05% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.11% | 0.14% | #28 | $920.4万 | 24.8万股 | $908.1万 | 26.8万股 | -2.0万股-7.61% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #163 | $812.6万 | 21.9万股 | $1,010.9万 | 29.9万股 | -8.0万股-26.71% | 减仓 |
| Palo Alto Investors LP |
| 1.16% | 1.11% | #11 | $792.7万 | 21.4万股 | $722.6万 | 21.4万股 | 00.00% | 持仓不变 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #148 | $737.3万 | 19.9万股 | $631.9万 | 18.7万股 | +1.2万股+6.37% | 加仓 |
