| RTW投资RTW INVESTMENTS, LP |
| 3.71% | 2.77% | #15 | $4.35亿 | 1,390.1万股 | $2.78亿 | 1,330.1万股 | +60.0万股+4.51% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | <0.01% | #114 | $3.89亿 | 1,243.8万股 | $1.83亿 | 874.8万股 | +369.0万股+42.19% | 加仓 |
| 富达投资FMR LLC |
| 0.02% | 0.01% | #87 | $3.86亿 | 1,233.3万股 | $2.07亿 | 990.6万股 | +242.7万股+24.50% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 1.77% | 1.08% | #23 | $3.84亿 | 1,227.7万股 | $1.90亿 | 909.7万股 | +318.0万股+34.95% | 加仓 |
| Boxer Capital Management, LLC |
| 25.61% | 29.87% | #2 | $3.40亿 | 1,087.6万股 | $2.28亿 | 1,087.6万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.03% | 0.01% | #79 | $3.12亿 | 998.1万股 | $1.06亿 | 507.6万股 | +490.4万股+96.61% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 6.82% | 6.3% | #5 | $2.84亿 | 908.1万股 | $2.20亿 | 1,053.1万股 | -145.0万股-13.77% | 减仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 3.72% | 1.71% | #14 | $1.99亿 | 635.8万股 | $8,388.2万 | 401.0万股 | +234.8万股+58.55% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | <0.01% | #85 | $1.98亿 | 634.9万股 | $1,860.8万 | 88.9万股 | +545.9万股+613.83% | 加仓 |
| Siren, L.L.C. |
| 3.91% | 3.28% | #12 | $1.93亿 | 617.9万股 | $1.18亿 | 565.7万股 | +52.2万股+9.23% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #117 | $1.87亿 | 598.0万股 | $9,731.8万 | 465.2万股 | +132.8万股+28.55% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #134 | $1.86亿 | 595.7万股 | $1.08亿 | 516.1万股 | +79.6万股+15.42% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.25% | 0.41% | #43 | $1.75亿 | 560.0万股 | $2.68亿 | 1,280.9万股 | -720.9万股-56.28% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.06% | — | #61 | $1.58亿 | 505.6万股 | $0 | 0股 | +505.6万股 | 新买入 |
| 深轨资本Deep Track Capital, LP |
| 1.91% | 0.94% | #21 | $1.31亿 | 420.0万股 | $5,753.0万 | 275.0万股 | +145.0万股+52.73% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.37% | 1.02% | #26 | $1.31亿 | 419.1万股 | $8,675.1万 | 414.7万股 | +4.4万股+1.06% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.39% | 0.63% | #39 | $1.25亿 | 400.1万股 | $1.67亿 | 800.0万股 | -399.9万股-49.99% | 减仓 |
| TRV GP IV, LLC |
| 47.37% | 49.96% | #1 | $1.20亿 | 637.5万股 | $1.33亿 | 637.5万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #111 | $1.17亿 | 374.3万股 | $5,599.0万 | 267.6万股 | +106.7万股+39.88% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.58% | 0.33% | #25 | $1.06亿 | 337.7万股 | $1,690.7万 | 80.8万股 | +256.9万股+317.87% | 加仓 |
| Seven Fleet Capital Management LP |
| 15.79% | 3.33% | #3 | $9,566.1万 | 322.8万股 | $1,050.2万 | 50.2万股 | +272.6万股+543.04% | 加仓 |
| Logos Global Management LP |
| 3.84% | 3.13% | #13 | $8,909.1万 | 285.0万股 | $6,276.0万 | 300.0万股 | -15.0万股-5.00% | 减仓 |
| Caligan Partners LP |
| 3.68% | 3.35% | #16 | $7,815.3万 | 250.0万股 | $5,039.2万 | 240.9万股 | +9.1万股+3.79% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.17% | 0.2% | #48 | $7,536.6万 | 241.1万股 | $8,227.0万 | 393.3万股 | -152.2万股-38.69% | 减仓 |
| Commodore Capital LP |
| 4.19% | — | #10 | $7,033.5万 | 225.0万股 | $0 | 0股 | +225.0万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.08% | 0.1% | #57 | $6,615.8万 | 211.6万股 | $8,005.4万 | 382.7万股 | -171.0万股-44.69% | 减仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.41% | — | #37 | $6,284.9万 | 201.1万股 | $0 | 0股 | +201.1万股 | 新买入 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #93 | $5,899.4万 | 188.7万股 | $2,711.8万 | 129.6万股 | +59.1万股+45.59% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.23% | 0.03% | #44 | $5,092.2万 | 163.1万股 | $628.0万 | 70.9万股 | +92.2万股+130.04% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #148 | $4,955.1万 | 158.5万股 | $1,885.9万 | 90.1万股 | +68.4万股+75.84% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #146 | $4,631.8万 | 141.8万股 | $129.3万 | 6.7万股 | +135.1万股+2,006.46% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.11% | — | #53 | $4,628.8万 | 148.1万股 | $0 | 0股 | +148.1万股 | 新买入 |
| Vivo Capital, LLC |
| 3.94% | 3.75% | #11 | $4,313.2万 | 138.0万股 | $4,507.8万 | 215.5万股 | -77.5万股-35.97% | 减仓 |
| DV EQUITIES, LLC |
| 5.91% | — | #6 | $4,121.8万 | 131.9万股 | $0 | 0股 | +131.9万股 | 新买入 |
| Cormorant Asset Management, LP |
| 2.06% | 1.5% | #20 | $4,063.8万 | 130.0万股 | $2,981.1万 | 142.5万股 | -12.5万股-8.77% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #127 | $3,851.0万 | 123.2万股 | $1,805.3万 | 86.3万股 | +36.9万股+42.76% | 加仓 |
| STEMPOINT CAPITAL LP |
| 5.47% | 0.78% | #7 | $3,840.7万 | 132.3万股 | $420.3万 | 20.1万股 | +112.2万股+558.48% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.05% | <0.01% | #65 | $3,796.9万 | 121.5万股 | $7,406 | 354股 | +121.4万股+343,011.02% | 加仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | <0.01% | #77 | $3,448.1万 | 110.3万股 | $367.1万 | 17.5万股 | +92.8万股+528.62% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #128 | $3,351.3万 | 107.2万股 | $1,754.5万 | 83.9万股 | +23.3万股+27.83% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.01% | — | #89 | $3,169.1万 | 101.4万股 | $0 | 0股 | +101.4万股 | 新买入 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 1.23% | 0.45% | #27 | $3,126.0万 | 100.0万股 | $941.4万 | 45.0万股 | +55.0万股+122.22% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #110 | $2,862.1万 | 91.6万股 | $1,386.8万 | 66.3万股 | +25.3万股+38.11% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #108 | $2,782.7万 | 89.0万股 | $754.8万 | 36.1万股 | +52.9万股+146.71% | 加仓 |
| 萨姆林资本SAMLYN CAPITAL, LLC |
| 0.39% | — | #38 | $2,396.0万 | 76.6万股 | $0 | 0股 | +76.6万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | — | #75 | $2,339.2万 | 74.8万股 | $0 | 0股 | +74.8万股 | 新买入 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.76% | 0.38% | #32 | $2,216.3万 | 70.9万股 | $941.4万 | 45.0万股 | +25.9万股+57.56% | 加仓 |
| ArrowMark Colorado Holdings LLC |
| 0.92% | 0.39% | #30 | $2,214.4万 | 70.8万股 | $1,481.9万 | 70.8万股 | 00.00% | 持仓不变 |
| Bellevue 集团Bellevue Group AG |
| 0.46% | 1.19% | #36 | $2,170.0万 | 69.4万股 | $5,020.8万 | 240.0万股 | -170.6万股-71.08% | 减仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.06% | <0.01% | #64 | $2,160.4万 | 69.1万股 | $36.0万 | 1.7万股 | +67.4万股+3,918.54% | 加仓 |
