| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #129 | $2.39亿 | 2,389.3万股 | $2.16亿 | 2,265.1万股 | +124.2万股+5.48% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.38% | 1.6% | #9 | $1.58亿 | 1,582.7万股 | $1.51亿 | 1,582.7万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #118 | $1.52亿 | 1,519.1万股 | $1.16亿 | 1,220.8万股 | +298.3万股+24.43% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.57% | 1.69% | #6 | $1.51亿 | 1,509.6万股 | $1.43亿 | 1,503.8万股 | +5.8万股+0.39% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #152 | $1.14亿 | 1,136.4万股 | $1.06亿 | 1,113.6万股 | +22.8万股+2.05% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #113 | $1.11亿 | 1,113.9万股 | $1.07亿 | 1,124.5万股 | -10.5万股-0.94% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 2.65% | 3% | #1 | $1.10亿 | 1,102.1万股 | $1.05亿 | 1,102.1万股 | 00.00% | 持仓不变 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.55% | 1.38% | #7 | $1.03亿 | 1,030.9万股 | $7,077.2万 | 743.4万股 | +287.5万股+38.67% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.04% | — | #58 | $9,526.8万 | 954.1万股 | $0 | 0股 | +954.1万股 | 新买入 |
| Vestal Point 资本Vestal Point Capital, LP |
| 1.94% | 1.87% | #2 | $8,300.0万 | 830.0万股 | $6,687.8万 | 702.5万股 | +127.5万股+18.15% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.05% | 0.05% | #53 | $6,775.3万 | 677.5万股 | $6,085.8万 | 639.3万股 | +38.3万股+5.99% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #132 | $6,249.3万 | 624.8万股 | $5,506.3万 | 578.3万股 | +46.5万股+8.05% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.07% | 0.08% | #44 | $5,310.9万 | 531.1万股 | $4,798.7万 | 504.1万股 | +27.0万股+5.36% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #104 | $5,078.3万 | 507.8万股 | $4,706.7万 | 494.4万股 | +13.4万股+2.72% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #140 | $4,801.3万 | 480.1万股 | $4,847.4万 | 509.2万股 | -29.0万股-5.70% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #124 | $4,481.9万 | 448.2万股 | $2,234.8万 | 234.7万股 | +213.4万股+90.93% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.87% | 0.98% | #13 | $4,009.2万 | 400.9万股 | $3,816.8万 | 400.9万股 | 00.00% | 持仓不变 |
| 纽文Nuveen, LLC |
| 0.01% | 0.01% | #96 | $4,007.2万 | 400.7万股 | $3,635.9万 | 381.9万股 | +18.8万股+4.92% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #135 | $3,816.1万 | 381.6万股 | $1,164.5万 | 122.3万股 | +259.3万股+211.97% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #89 | $3,394.7万 | 339.5万股 | $302.5万 | 31.8万股 | +307.7万股+968.46% | 加仓 |
| GW&K Investment Management, LLC |
| 0.25% | 0.27% | #27 | $3,171.1万 | 317.1万股 | $3,085.0万 | 324.0万股 | -6.9万股-2.14% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | 0.01% | #115 | $2,718.8万 | 271.9万股 | $2,561.5万 | 269.1万股 | +2.8万股+1.05% | 加仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.01% | 0.01% | #98 | $2,604.0万 | 260.4万股 | $2,602.1万 | 273.3万股 | -12.9万股-4.73% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | 0.01% | #61 | $2,530.3万 | 253.0万股 | $739.7万 | 77.7万股 | +175.3万股+225.65% | 加仓 |
| Kynam Capital Management, LP |
| 1.39% | 3.34% | #8 | $2,522.7万 | 252.3万股 | $5,408.1万 | 568.1万股 | -315.8万股-55.59% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.11% | — | #35 | $2,512.5万 | 251.5万股 | $0 | 0股 | +251.5万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #138 | $2,353.3万 | 235.3万股 | $2,237.6万 | 235.0万股 | +2,886股+0.12% | 加仓 |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 1.13% | 1.18% | #11 | $2,332.0万 | 233.2万股 | $2,123.1万 | 223.0万股 | +10.2万股+4.57% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #149 | $2,255.7万 | 225.6万股 | $2,003.7万 | 210.5万股 | +15.1万股+7.17% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #99 | $2,214.3万 | 221.4万股 | $419.0万 | 44.0万股 | +177.4万股+403.09% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #151 | $2,136.4万 | 213.6万股 | $1,156.6万 | 121.5万股 | +92.1万股+75.84% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #209 | $1,999.7万 | 200.0万股 | $3,949.0万 | 520.3万股 | -320.3万股-61.57% | 减仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.63% | 0.7% | #16 | $1,901.2万 | 190.1万股 | $1,892.0万 | 198.7万股 | -8.6万股-4.34% | 减仓 |
| Eversept Partners, LP |
| 0.97% | 1.53% | #12 | $1,865.7万 | 186.6万股 | $2,893.9万 | 304.0万股 | -117.4万股-38.63% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.35% | 0.27% | #23 | $1,852.0万 | 185.2万股 | $1,356.8万 | 142.5万股 | +42.7万股+29.95% | 加仓 |
| 安大略医疗养老基金(HOOPP)HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.03% | 0.02% | #67 | $1,844.9万 | 184.5万股 | $1,168.1万 | 122.7万股 | +61.8万股+50.35% | 加仓 |
| Stifel金融STIFEL FINANCIAL CORP |
| 0.02% | 0.02% | #80 | $1,826.2万 | 182.6万股 | $1,737.6万 | 182.5万股 | +1,050股+0.06% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #125 | $1,759.6万 | 176.0万股 | $1,584.4万 | 166.4万股 | +9.5万股+5.72% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #190 | $1,704.8万 | 170.5万股 | $3,000.4万 | 315.2万股 | -144.7万股-45.91% | 减仓 |
| 木星资产管理JUPITER ASSET MANAGEMENT LTD |
| 0.08% | 0.06% | #42 | $1,642.9万 | 164.3万股 | $1,138.9万 | 119.6万股 | +44.7万股+37.32% | 加仓 |
| IMC芝加哥IMC-Chicago, LLC |
| <0.01% | <0.01% | #123 | $1,634.3万 | 163.4万股 | $601.0万 | 63.1万股 | +100.3万股+158.89% | 加仓 |
| Parkman Healthcare Partners LLC |
| 1.66% | 1.68% | #5 | $1,624.3万 | 162.4万股 | $1,626.1万 | 170.8万股 | -8.4万股-4.91% | 减仓 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | <0.01% | #141 | $1,455.5万 | 145.6万股 | $1,343.5万 | 141.1万股 | +4.4万股+3.14% | 加仓 |
| OP资产管理OP Asset Management Ltd |
| 0.14% | 0.01% | #31 | $1,341.0万 | 134.1万股 | $108.6万 | 13.9万股 | +120.2万股+863.31% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #216 | $1,233.8万 | 123.4万股 | $1,246.0万 | 130.9万股 | -7.5万股-5.73% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.01% | <0.01% | #90 | $1,195.1万 | 125.0万股 | $445.9万 | 47.2万股 | +77.8万股+165.02% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.01% | #110 | $1,174.1万 | 117.4万股 | $1,239.7万 | 130.2万股 | -12.8万股-9.84% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | 0.01% | #103 | $1,120.5万 | 112.0万股 | $762.5万 | 80.1万股 | +32.0万股+39.90% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| 0.02% | — | #75 | $1,081.5万 | 108.2万股 | $0 | 0股 | +108.2万股 | 新买入 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.13% | — | #32 | $848.3万 | 84.8万股 | $0 | 0股 | +84.8万股 | 新买入 |
