| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.27% | 0.11% | #20 | $4.16亿 | 1,617.9万股 | $1.64亿 | 851.9万股 | +766.0万股+89.91% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | <0.01% | #116 | $3.61亿 | 1,402.6万股 | $2.50亿 | 1,303.4万股 | +99.2万股+7.61% | 加仓 |
| 百利吉福德BAILLIE GIFFORD & CO |
| 0.28% | 0.23% | #19 | $3.08亿 | 1,196.0万股 | $2.32亿 | 1,206.6万股 | -10.6万股-0.88% | 减仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #115 | $1.81亿 | 704.9万股 | $1.20亿 | 627.2万股 | +77.7万股+12.39% | 加仓 |
| 淡马锡控股Temasek Holdings (Private) Ltd |
| 0.48% | 0.44% | #14 | $1.80亿 | 701.3万股 | $1.35亿 | 701.3万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #102 | $1.67亿 | 647.7万股 | $1.18亿 | 612.0万股 | +35.7万股+5.83% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #140 | $1.61亿 | 627.6万股 | $1.18亿 | 614.8万股 | +12.8万股+2.08% | 加仓 |
| 富达投资FMR LLC |
| 0.01% | <0.01% | #119 | $1.17亿 | 453.6万股 | $8,784.7万 | 457.5万股 | -4.0万股-0.86% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #92 | $1.07亿 | 415.6万股 | $8,461.9万 | 440.7万股 | -25.1万股-5.70% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #113 | $1.02亿 | 397.3万股 | $7,157.5万 | 372.7万股 | +24.6万股+6.61% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.23% | 0.15% | #23 | $1.00亿 | 390.5万股 | $6,135.2万 | 319.5万股 | +71.0万股+22.21% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.48% | 0.41% | #15 | $9,604.7万 | 373.4万股 | $7,164.9万 | 373.2万股 | +2,641股+0.07% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | 0.02% | #77 | $8,132.6万 | 316.2万股 | $8,510.0万 | 443.2万股 | -127.0万股-28.66% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.01% | #100 | $8,066.2万 | 313.6万股 | $4,731.3万 | 246.4万股 | +67.2万股+27.27% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #88 | $8,026.2万 | 312.1万股 | $4,937.0万 | 257.1万股 | +54.9万股+21.36% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #80 | $7,357.5万 | 286.1万股 | $5,168.7万 | 269.2万股 | +16.8万股+6.26% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | 0.01% | #104 | $7,265.2万 | 282.5万股 | $4,143.2万 | 304.8万股 | -22.3万股-7.31% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.07% | 0.05% | #40 | $7,189.5万 | 279.1万股 | $4,843.9万 | 255.9万股 | +23.2万股+9.08% | 加仓 |
| 资本研究全球投资者Capital Research Global Investors |
| 0.01% | 0.01% | #93 | $6,599.3万 | 256.6万股 | $4,828.0万 | 251.5万股 | +5.1万股+2.04% | 加仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.02% | 0.02% | #72 | $6,209.2万 | 241.4万股 | $4,678.8万 | 243.7万股 | -2.3万股-0.93% | 减仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.02% | #69 | $5,730.8万 | 298.5万股 | $4,777.4万 | 289.4万股 | +9.1万股+3.15% | 加仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.09% | <0.01% | #36 | $5,679.7万 | 220.8万股 | $219.9万 | 11.5万股 | +209.4万股+1,828.21% | 加仓 |
| Casdin Capital, LLC |
| 2.63% | 2.68% | #4 | $5,259.7万 | 204.5万股 | $3,532.8万 | 184.0万股 | +20.5万股+11.14% | 加仓 |
| Crestline Management, L.P. |
| 91.9% | 91.74% | #1 | $4,914.4万 | 191.1万股 | $4,244.6万 | 221.1万股 | -30.0万股-13.57% | 减仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.02% | 0.02% | #73 | $3,652.5万 | 142.0万股 | $2,838.7万 | 147.8万股 | -5.8万股-3.95% | 减仓 |
| Foresite Capital Management VI LLC |
| 5.59% | 5.05% | #2 | $3,592.5万 | 139.7万股 | $2,323.1万 | 121.0万股 | +18.7万股+15.44% | 加仓 |
| Siren, L.L.C. |
| 0.73% | 0.74% | #10 | $3,591.8万 | 139.7万股 | $2,681.3万 | 139.7万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #128 | $3,574.5万 | 139.0万股 | $2,516.5万 | 131.1万股 | +7.9万股+6.04% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.03% | — | #54 | $3,486.4万 | 135.6万股 | $0 | 0股 | +135.6万股 | 新买入 |
| 安本标准投资Aberdeen Group plc |
| 0.05% | 0.06% | #47 | $3,460.6万 | 134.5万股 | $3,560.5万 | 185.4万股 | -50.9万股-27.45% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #125 | $3,202.0万 | 124.5万股 | $2,318.2万 | 120.7万股 | +3.8万股+3.11% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #159 | $3,166.0万 | 123.1万股 | $2,177.6万 | 113.4万股 | +9.7万股+8.53% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.05% | 0.03% | #46 | $3,149.4万 | 122.4万股 | $2,111.5万 | 110.0万股 | +12.5万股+11.35% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.14% | 0.1% | #27 | $3,057.4万 | 119.0万股 | $1,925.8万 | 116.6万股 | +2.4万股+2.02% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #90 | $2,895.4万 | 112.6万股 | $2,444.1万 | 127.3万股 | -14.7万股-11.56% | 减仓 |
| ADAR1 Capital Management, LLC |
| 1.22% | 2.12% | #7 | $2,646.8万 | 102.9万股 | $3,593.2万 | 187.1万股 | -84.2万股-45.01% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #111 | $2,551.2万 | 99.2万股 | $1,823.4万 | 95.0万股 | +4.2万股+4.44% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #175 | $2,471.8万 | 96.1万股 | $2,453.1万 | 168.9万股 | -72.8万股-43.12% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #142 | $2,058.3万 | 80.0万股 | $1,474.6万 | 76.8万股 | +3.2万股+4.20% | 加仓 |
| DAFNA Capital Management LLC |
| 3.62% | 1.39% | #3 | $1,900.7万 | 73.9万股 | $611.5万 | 31.9万股 | +42.1万股+132.03% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.01% | 0.01% | #99 | $1,832.6万 | 71.3万股 | $1,796.5万 | 93.6万股 | -22.3万股-23.85% | 减仓 |
| Cercano Management LLC |
| 1.4% | 0.52% | #5 | $1,607.5万 | 62.5万股 | $1,200.0万 | 62.5万股 | 00.00% | 持仓不变 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #136 | $1,566.3万 | 60.9万股 | $567.5万 | 29.6万股 | +31.3万股+106.02% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #163 | $1,543.4万 | 60.0万股 | $674.0万 | 35.1万股 | +24.9万股+70.95% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.02% | 0.02% | #67 | $1,498.6万 | 58.3万股 | $990.2万 | 51.6万股 | +6.7万股+12.98% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.02% | #87 | $1,414.2万 | 55.0万股 | $1,903.2万 | 99.1万股 | -44.1万股-44.53% | 减仓 |
| 西格尔·布莱恩特·哈米尔SEGALL BRYANT & HAMILL, LLC |
| 0.16% | 0.14% | #26 | $1,336.1万 | 51.9万股 | $980.2万 | 51.1万股 | +8,940股+1.75% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #129 | $1,253.3万 | 48.7万股 | $190.6万 | 9.9万股 | +38.8万股+390.82% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | <0.01% | #79 | $1,113.2万 | 43.3万股 | $374.6万 | 19.5万股 | +23.8万股+121.83% | 加仓 |
| Defilade Capital Management, L.P. |
| 1.35% | 3.67% | #6 | $1,007.9万 | 39.2万股 | $2,611.1万 | 136.0万股 | -96.8万股-71.19% | 减仓 |
