| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #121 | $1.97亿 | 902.0万股 | $1.93亿 | 825.4万股 | +76.6万股+9.27% | 加仓 |
| Kynam Capital Management, LP |
| 9.73% | 11.6% | #2 | $1.76亿 | 805.1万股 | $1.88亿 | 805.1万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #84 | $1.28亿 | 586.1万股 | $1.17亿 | 499.7万股 | +86.4万股+17.30% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #117 | $1.24亿 | 565.8万股 | $1.03亿 | 443.0万股 | +122.8万股+27.73% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #104 | $8,842.6万 | 404.5万股 | $9,927.6万 | 425.0万股 | -20.5万股-4.82% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #140 | $8,586.4万 | 392.8万股 | $8,929.5万 | 382.3万股 | +10.5万股+2.76% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.86% | 1.04% | #23 | $8,262.9万 | 378.0万股 | $8,829.8万 | 378.0万股 | 00.00% | 持仓不变 |
| Eversept Partners, LP |
| 3.17% | 3.55% | #10 | $6,116.9万 | 279.8万股 | $6,740.8万 | 288.6万股 | -8.7万股-3.03% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #120 | $5,650.0万 | 258.4万股 | $5,039.9万 | 215.7万股 | +42.7万股+19.80% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 0.41% | 0.55% | #28 | $5,605.5万 | 256.4万股 | $5,499.6万 | 235.4万股 | +21.0万股+8.92% | 加仓 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 5.6% | 6.41% | #4 | $5,465.0万 | 250.0万股 | $5,840.0万 | 250.0万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #85 | $4,998.3万 | 228.6万股 | $5,022.6万 | 215.0万股 | +13.6万股+6.34% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.02% | <0.01% | #78 | $4,490.0万 | 205.4万股 | $466.1万 | 20.0万股 | +185.4万股+929.43% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #138 | $4,201.0万 | 192.2万股 | $4,058.0万 | 173.7万股 | +18.5万股+10.63% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | <0.01% | #106 | $4,139.7万 | 189.4万股 | $2,695.0万 | 115.4万股 | +74.0万股+64.15% | 加仓 |
| Elmind Capital, LP |
| 10.19% | 12.3% | #1 | $4,055.0万 | 185.5万股 | $4,333.3万 | 185.5万股 | 00.00% | 持仓不变 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.04% | — | #62 | $3,913.3万 | 179.0万股 | $0 | 0股 | +179.0万股 | 新买入 |
| 康得利安资管Candriam S.C.A. |
| 0.17% | 0.1% | #42 | $3,704.0万 | 169.6万股 | $1,944.2万 | 92.5万股 | +77.1万股+83.29% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 1.23% | 1.63% | #18 | $3,558.9万 | 162.8万股 | $4,034.1万 | 172.7万股 | -9.9万股-5.73% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.03% | #70 | $3,449.8万 | 157.8万股 | $3,689.9万 | 158.0万股 | -1,471股-0.09% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.64% | 0.45% | #24 | $3,370.8万 | 154.2万股 | $2,247.9万 | 96.2万股 | +58.0万股+60.24% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | 0.01% | #94 | $2,983.0万 | 136.5万股 | $3,491.5万 | 149.5万股 | -13.0万股-8.70% | 减仓 |
| MPM BioImpact LLC |
| 1.78% | 2.42% | #15 | $2,915.1万 | 133.4万股 | $3,132.0万 | 134.1万股 | -7,210股-0.54% | 减仓 |
| Aisling Capital Management LP |
| 6.1% | 6.46% | #3 | $2,878.5万 | 131.7万股 | $3,076.1万 | 131.7万股 | 00.00% | 持仓不变 |
| Woodline合伙人Woodline Partners LP |
| 0.08% | 0.11% | #51 | $2,734.2万 | 125.1万股 | $2,921.8万 | 125.1万股 | 00.00% | 持仓不变 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.02% | #80 | $2,710.5万 | 124.0万股 | $3,742.0万 | 160.2万股 | -36.2万股-22.59% | 减仓 |
| Catalio Capital Management, LP |
| 4.99% | 5.09% | #6 | $2,657.5万 | 121.6万股 | $2,438.0万 | 104.4万股 | +17.2万股+16.48% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 2.76% | 2.12% | #13 | $2,654.7万 | 121.4万股 | $2,076.7万 | 88.9万股 | +32.5万股+36.60% | 加仓 |
| Prosight Management, LP |
| 4.52% | 2.95% | #7 | $2,623.2万 | 120.0万股 | $1,798.7万 | 77.0万股 | +43.0万股+55.84% | 加仓 |
| Trails Edge Capital Partners, LP |
| 3.85% | 3.76% | #8 | $2,426.5万 | 111.0万股 | $1,639.5万 | 70.2万股 | +40.8万股+58.16% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.27% | 0.33% | #33 | $2,298.5万 | 105.1万股 | $2,169.1万 | 92.9万股 | +12.3万股+13.24% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #115 | $2,273.6万 | 104.0万股 | $2,346.5万 | 100.4万股 | +3.6万股+3.54% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 2.9% | 2.69% | #11 | $2,217.9万 | 101.5万股 | $1,692.6万 | 72.5万股 | +29.0万股+40.03% | 加仓 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.03% | — | #69 | $2,019.0万 | 92.4万股 | $0 | 0股 | +92.4万股 | 新买入 |
| Parkman Healthcare Partners LLC |
| 1.96% | 2.17% | #14 | $1,917.7万 | 87.7万股 | $2,105.9万 | 90.2万股 | -2.4万股-2.69% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.03% | 0.04% | #66 | $1,897.1万 | 86.8万股 | $2,314.9万 | 99.1万股 | -12.3万股-12.43% | 减仓 |
| Palo Alto Investors LP |
| 2.76% | 3.09% | #12 | $1,890.9万 | 86.5万股 | $2,020.6万 | 86.5万股 | 00.00% | 持仓不变 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #96 | $1,865.3万 | 85.3万股 | $2,290.0万 | 98.0万股 | -12.7万股-12.96% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #133 | $1,848.3万 | 84.6万股 | $1,765.4万 | 75.6万股 | +9.0万股+11.89% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #125 | $1,780.1万 | 81.4万股 | $1,670.6万 | 71.5万股 | +9.9万股+13.86% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #151 | $1,664.4万 | 76.1万股 | $1,102.9万 | 47.2万股 | +28.9万股+61.27% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #119 | $1,384.9万 | 63.4万股 | $1,402.8万 | 60.1万股 | +3.3万股+5.49% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #173 | $1,287.5万 | 58.9万股 | $1,845.1万 | 119.9万股 | -61.0万股-50.89% | 减仓 |
| Rhenman & Partners Asset Management AB |
| 1.16% | 1.09% | #20 | $1,224.7万 | 56.0万股 | $885.9万 | 37.9万股 | +18.1万股+47.73% | 加仓 |
| APIS CAPITAL ADVISORS, LLC |
| 1.18% | 1.98% | #19 | $1,215.4万 | 55.6万股 | $1,284.8万 | 55.0万股 | +6,000股+1.09% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.04% | 0.02% | #63 | $1,194.7万 | 54.7万股 | $582.6万 | 24.9万股 | +29.7万股+119.13% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | <0.01% | #87 | $1,043.1万 | 47.7万股 | $84.2万 | 3.6万股 | +44.1万股+1,223.78% | 加仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | — | #103 | $998.3万 | 45.7万股 | $0 | 0股 | +45.7万股 | 新买入 |
| Granahan 投资管理Granahan Investment Management, LLC |
| 0.35% | 0.35% | #30 | $977.1万 | 44.7万股 | $715.6万 | 30.6万股 | +14.1万股+45.92% | 加仓 |
| Knott David M Jr |
| 5.1% | 5.96% | #5 | $955.8万 | 43.7万股 | $985.8万 | 42.2万股 | +1.5万股+3.61% | 加仓 |
