| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 13.35% | 13.96% | #3 | $6.13亿 | 1,808.9万股 | $5.42亿 | 1,694.4万股 | +114.5万股+6.76% | 加仓 |
| 资本世界投资者Capital World Investors |
| 0.05% | 0.05% | #60 | $4.14亿 | 1,223.1万股 | $3.56亿 | 1,110.9万股 | +112.2万股+10.10% | 加仓 |
| 富达投资FMR LLC |
| 0.02% | 0.01% | #77 | $3.50亿 | 1,034.0万股 | $2.81亿 | 876.6万股 | +157.4万股+17.95% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 2.81% | 3.24% | #6 | $3.24亿 | 955.0万股 | $3.06亿 | 955.0万股 | 00.00% | 持仓不变 |
| FCPM III SERVICES B.V. |
| 38.34% | 40.77% | #2 | $2.88亿 | 849.0万股 | $2.94亿 | 919.9万股 | -70.9万股-7.70% | 减仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.51% | 1.61% | #10 | $1.45亿 | 426.5万股 | $1.37亿 | 426.5万股 | 00.00% | 持仓不变 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.41% | 0.38% | #23 | $1.42亿 | 420.4万股 | $1.35亿 | 420.4万股 | 00.00% | 持仓不变 |
| Bain Capital Life Sciences Investors, LLC |
| 7.67% | 21.09% | #4 | $1.29亿 | 380.7万股 | $2.34亿 | 730.7万股 | -350.0万股-47.90% | 减仓 |
| Maverick资本MAVERICK CAPITAL LTD |
| 0.98% | 0.81% | #12 | $1.11亿 | 326.8万股 | $6,998.7万 | 218.6万股 | +108.1万股+49.46% | 加仓 |
| 杜肯家族办公室Duquesne Family Office LLC |
| 2% | 2.91% | #9 | $1.04亿 | 307.0万股 | $9,827.5万 | 307.0万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.04% | — | #65 | $8,601.0万 | 253.6万股 | $0 | 0股 | +253.6万股 | 新买入 |
| Medicxi Ventures Management (Jersey) Ltd |
| 42.19% | 8.72% | #1 | $7,485.1万 | 220.9万股 | $8,560.1万 | 267.4万股 | -46.6万股-17.41% | 减仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.04% | 0.06% | #62 | $7,124.6万 | 210.2万股 | $8,804.0万 | 275.0万股 | -64.8万股-23.56% | 减仓 |
| Orbis Allan GrayOrbis Allan Gray Ltd |
| 0.2% | — | #36 | $5,922.7万 | 174.8万股 | $0 | 0股 | +174.8万股 | 新买入 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.14% | 0.32% | #45 | $5,844.4万 | 172.5万股 | $9,064.0万 | 283.2万股 | -110.7万股-39.10% | 减仓 |
| 资本国际投资者Capital International Investors |
| 0.01% | 0.01% | #84 | $5,840.9万 | 172.3万股 | $4,613.1万 | 144.1万股 | +28.2万股+19.59% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #97 | $5,293.3万 | 156.2万股 | $6,230.3万 | 194.6万股 | -38.4万股-19.75% | 减仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.17% | 0.3% | #40 | $5,207.1万 | 153.6万股 | $7,051.5万 | 220.3万股 | -66.6万股-30.25% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #103 | $4,985.0万 | 147.1万股 | $1,489.8万 | 46.5万股 | +100.6万股+216.04% | 加仓 |
| Castle Hook合伙人Castle Hook Partners LP |
| 0.21% | 0.67% | #35 | $4,646.3万 | 137.1万股 | $3,337.5万 | 104.3万股 | +32.8万股+31.49% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.01% | 0.01% | #90 | $4,248.3万 | 125.4万股 | $2,410.5万 | 75.3万股 | +50.0万股+66.46% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #79 | $4,033.1万 | 126.0万股 | $4,207.2万 | 119.9万股 | +6.1万股+5.05% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #102 | $3,956.2万 | 116.7万股 | $0 | 0股 | +116.7万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #119 | $3,837.3万 | 113.3万股 | $2,593.4万 | 88.4万股 | +24.9万股+28.13% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.05% | 0.04% | #58 | $3,737.3万 | 110.3万股 | $2,679.3万 | 83.7万股 | +26.6万股+31.75% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #153 | $3,605.0万 | 106.4万股 | $2,838.1万 | 88.7万股 | +17.7万股+19.98% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #93 | $3,368.4万 | 99.4万股 | $2,465.3万 | 77.0万股 | +22.4万股+29.05% | 加仓 |
| 时代广场资本管理TimesSquare Capital Management, LLC |
| 0.4% | 0.41% | #25 | $2,698.2万 | 79.6万股 | $2,407.1万 | 75.2万股 | +4.4万股+5.87% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.03% | — | #70 | $2,647.3万 | 78.1万股 | $0 | 0股 | +78.1万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.08% | 0.09% | #49 | $2,550.2万 | 75.2万股 | $2,408.1万 | 75.2万股 | +181股+0.02% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #129 | $2,492.6万 | 73.5万股 | $2,711.5万 | 84.7万股 | -11.2万股-13.18% | 减仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.16% | — | #43 | $2,449.3万 | 72.3万股 | $0 | 0股 | +72.3万股 | 新买入 |
| NWI MANAGEMENT LP |
| 1.1% | 1.14% | #11 | $2,379.1万 | 70.2万股 | $2,462.6万 | 70.2万股 | 00.00% | 持仓不变 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.01% | 0.01% | #88 | $2,320.8万 | 68.5万股 | $1,662.8万 | 51.9万股 | +16.5万股+31.83% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #113 | $2,318.8万 | 68.4万股 | $2,455.4万 | 76.7万股 | -8.3万股-10.80% | 减仓 |
| Rock Springs Capital Management LP |
| 0.96% | 1.11% | #13 | $1,974.9万 | 58.3万股 | $1,884.7万 | 58.9万股 | -6,050股-1.03% | 减仓 |
| First Turn Management, LLC |
| 2.11% | 2% | #8 | $1,974.1万 | 58.2万股 | $1,787.2万 | 55.8万股 | +2.4万股+4.33% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #141 | $1,951.5万 | 57.6万股 | $4,258.8万 | 149.7万股 | -92.2万股-61.55% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.03% | 0.05% | #71 | $1,864.0万 | 55.0万股 | $3,542.3万 | 110.7万股 | -55.7万股-50.30% | 减仓 |
| Artia Global Partners LP |
| 3.15% | 3.23% | #5 | $1,707.8万 | 50.4万股 | $1,613.1万 | 50.4万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | <0.01% | #94 | $1,700.0万 | 50.2万股 | $972.6万 | 30.4万股 | +19.8万股+65.09% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.25% | — | #30 | $1,694.5万 | 50.0万股 | $0 | 0股 | +50.0万股 | 新买入 |
| Cormorant Asset Management, LP |
| 0.86% | 1.53% | #15 | $1,694.5万 | 50.0万股 | $3,041.0万 | 95.0万股 | -45.0万股-47.37% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #136 | $1,672.6万 | 49.4万股 | $719.3万 | 22.5万股 | +26.9万股+119.64% | 加仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.25% | 0.28% | #31 | $1,428.0万 | 42.1万股 | $1,307.6万 | 40.8万股 | +1.3万股+3.15% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #125 | $1,197.3万 | 35.3万股 | $1,212.5万 | 37.9万股 | -2.6万股-6.73% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| 0.02% | — | #72 | $1,185.6万 | 35.0万股 | $0 | 0股 | +35.0万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #132 | $1,166.0万 | 34.4万股 | $2,544.7万 | 79.5万股 | -45.1万股-56.72% | 减仓 |
| 石板路径资本Slate Path Capital LP |
| 0.15% | 0.15% | #44 | $1,081.1万 | 31.9万股 | $1,021.1万 | 31.9万股 | 00.00% | 持仓不变 |
| LORD, ABBETT & CO. LLC |
| 0.03% | 0.02% | #69 | $1,038.9万 | 30.7万股 | $625.3万 | 19.5万股 | +11.1万股+56.92% | 加仓 |
