| 富达投资FMR LLC |
| 0.03% | 0.03% | #63 | $5.93亿 | 1,584.0万股 | $5.72亿 | 1,576.0万股 | +8.0万股+0.51% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #92 | $3.65亿 | 975.9万股 | $3.08亿 | 847.9万股 | +128.0万股+15.10% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 1.55% | 1.73% | #9 | $3.36亿 | 898.9万股 | $3.03亿 | 833.8万股 | +65.1万股+7.81% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.05% | 0.06% | #53 | $2.67亿 | 713.1万股 | $2.96亿 | 815.7万股 | -102.6万股-12.58% | 减仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.4% | 1.71% | #10 | $2.42亿 | 646.4万股 | $2.32亿 | 639.6万股 | +6.8万股+1.06% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.02% | #64 | $2.32亿 | 621.3万股 | $1.95亿 | 535.5万股 | +85.7万股+16.01% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #83 | $1.81亿 | 483.3万股 | $1.68亿 | 463.9万股 | +19.4万股+4.18% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #105 | $1.78亿 | 474.5万股 | $1.70亿 | 467.4万股 | +7.1万股+1.53% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.07% | — | #43 | $1.71亿 | 455.8万股 | $0 | 0股 | +455.8万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #91 | $1.02亿 | 272.8万股 | $9,011.9万 | 248.1万股 | +24.7万股+9.95% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #120 | $1.01亿 | 268.9万股 | $8,727.9万 | 240.3万股 | +28.6万股+11.91% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 2.06% | 2.84% | #6 | $9,804.0万 | 262.0万股 | $1.19亿 | 328.0万股 | -66.0万股-20.12% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.44% | 0.49% | #21 | $8,799.2万 | 235.1万股 | $8,540.5万 | 235.1万股 | 00.00% | 持仓不变 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.2% | — | #33 | $8,510.8万 | 227.4万股 | $0 | 0股 | +227.4万股 | 新买入 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.07% | 0.07% | #42 | $7,757.3万 | 207.5万股 | $6,820.4万 | 188.4万股 | +19.1万股+10.14% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.05% | 0.05% | #50 | $7,522.5万 | 201.0万股 | $7,048.4万 | 194.1万股 | +7.0万股+3.59% | 加仓 |
| GW&K Investment Management, LLC |
| 0.51% | 0.52% | #19 | $6,477.9万 | 173.1万股 | $5,879.1万 | 161.9万股 | +11.2万股+6.95% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.06% | — | #45 | $6,280.9万 | 167.8万股 | $0 | 0股 | +167.8万股 | 新买入 |
| Siren, L.L.C. |
| 1.08% | 1.92% | #13 | $5,316.6万 | 142.1万股 | $6,914.0万 | 190.4万股 | -48.3万股-25.36% | 减仓 |
| First Light Asset Management, LLC |
| 3.1% | 3.55% | #2 | $5,092.4万 | 136.1万股 | $3,957.7万 | 109.0万股 | +27.1万股+24.89% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #123 | $5,060.3万 | 136.5万股 | $4,539.6万 | 132.5万股 | +4.0万股+3.05% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #126 | $5,008.8万 | 133.9万股 | $2,841.1万 | 68.2万股 | +65.6万股+96.23% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #117 | $4,988.4万 | 133.3万股 | $2,601.0万 | 71.6万股 | +61.7万股+86.15% | 加仓 |
| Novo Holdings A/S |
| 2.88% | 4.56% | #3 | $4,939.4万 | 132.0万股 | $5,629.6万 | 155.0万股 | -23.0万股-14.84% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #78 | $4,753.9万 | 127.1万股 | $3,093.5万 | 85.2万股 | +41.8万股+49.08% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #66 | $4,724.5万 | 126.3万股 | $3,824.0万 | 105.3万股 | +21.0万股+19.92% | 加仓 |
| ADAR1 Capital Management, LLC |
| 2.11% | 2.44% | #5 | $4,573.0万 | 122.2万股 | $4,138.1万 | 113.9万股 | +8.3万股+7.26% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 0.81% | 0.97% | #16 | $4,439.1万 | 118.6万股 | $3,791.4万 | 104.4万股 | +14.2万股+13.64% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.03% | 0.02% | #58 | $4,215.9万 | 112.7万股 | $2,484.7万 | 68.4万股 | +44.3万股+64.69% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #113 | $4,134.9万 | 110.5万股 | $2,281.5万 | 62.8万股 | +47.7万股+75.91% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.71% | 0.72% | #17 | $3,738.3万 | 99.9万股 | $3,628.4万 | 99.9万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #100 | $3,647.6万 | 97.5万股 | $3,055.6万 | 84.1万股 | +13.3万股+15.87% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 0.26% | 0.33% | #29 | $3,626.0万 | 96.9万股 | $3,295.7万 | 90.7万股 | +6.2万股+6.79% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #99 | $3,284.1万 | 87.8万股 | $3,027.0万 | 83.3万股 | +4.4万股+5.31% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.04% | 0.05% | #54 | $3,069.9万 | 82.0万股 | $2,979.7万 | 82.0万股 | 00.00% | 持仓不变 |
| 康得利安资管Candriam S.C.A. |
| 0.14% | 0.19% | #34 | $3,061.9万 | 81.9万股 | $3,868.3万 | 83.1万股 | -1.2万股-1.44% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #86 | $2,823.1万 | 75.4万股 | $2,573.2万 | 70.8万股 | +4.6万股+6.49% | 加仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.01% | 0.01% | #82 | $2,774.9万 | 74.2万股 | $2,770.1万 | 76.3万股 | -2.1万股-2.77% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #125 | $2,099.9万 | 56.1万股 | $2,077.1万 | 57.2万股 | -1.1万股-1.88% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | 0.01% | #95 | $2,078.2万 | 55.5万股 | $2,002.9万 | 55.1万股 | +3,917股+0.71% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | 0.01% | #107 | $1,860.6万 | 49.7万股 | $2,899.6万 | 79.8万股 | -30.1万股-37.72% | 减仓 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| 0.01% | 0.01% | #72 | $1,775.0万 | 48.1万股 | $1,310.4万 | 38.2万股 | +9.8万股+25.67% | 加仓 |
| Impax资产管理Impax Asset Management Group plc |
| 0.11% | 0.09% | #38 | $1,627.8万 | 43.5万股 | $1,271.2万 | 35.0万股 | +8.5万股+24.29% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #128 | $1,473.2万 | 39.4万股 | $1,302.9万 | 35.9万股 | +3.5万股+9.75% | 加仓 |
| Prosight Management, LP |
| 2.42% | 2.08% | #4 | $1,402.0万 | 37.5万股 | $1,271.2万 | 35.0万股 | +2.5万股+7.05% | 加仓 |
| Universal投资服务Universal- Beteiligungs- und Servicegesellschaft mbH |
| 0.02% | 0.02% | #65 | $1,399.2万 | 37.4万股 | $1,545.8万 | 42.6万股 | -5.2万股-12.15% | 减仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.24% | — | #30 | $1,368.5万 | 36.6万股 | $0 | 0股 | +36.6万股 | 新买入 |
| BRAUN STACEY 联合公司BRAUN STACEY ASSOCIATES INC |
| 0.37% | 0.39% | #22 | $1,302.8万 | 34.8万股 | $1,179.7万 | 32.5万股 | +2.3万股+7.18% | 加仓 |
| Fiera资本Fiera Capital Corp |
| 0.05% | 0.07% | #52 | $1,267.9万 | 33.9万股 | $2,141.6万 | 59.0万股 | -25.1万股-42.54% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #119 | $1,061.7万 | 28.4万股 | $935.3万 | 25.8万股 | +2.6万股+10.17% | 加仓 |
