| 富达投资FMR LLC |
| 0.02% | 0.02% | #75 | $4.46亿 | 697.1万股 | $3.29亿 | 682.4万股 | +14.8万股+2.16% | 加仓 |
| Rubric资本管理Rubric Capital Management LP |
| 2.35% | 1.91% | #3 | $2.56亿 | 400.0万股 | $1.81亿 | 375.0万股 | +25.0万股+6.66% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.91% | 0.78% | #9 | $1.81亿 | 283.5万股 | $1.36亿 | 282.6万股 | +8,397股+0.30% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #141 | $1.75亿 | 274.0万股 | $2,343.6万 | 48.7万股 | +225.3万股+462.85% | 加仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 6.56% | 5.53% | #2 | $1.45亿 | 226.0万股 | $1.09亿 | 226.0万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #116 | $1.22亿 | 191.1万股 | $8,504.6万 | 176.6万股 | +14.5万股+8.21% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #157 | $8,702.6万 | 136.1万股 | $6,418.8万 | 133.3万股 | +2.8万股+2.08% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #127 | $6,466.3万 | 101.1万股 | $5,292.2万 | 136.3万股 | -35.2万股-25.81% | 减仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.03% | 0.02% | #64 | $6,123.3万 | 95.8万股 | $4,298.2万 | 89.3万股 | +6.5万股+7.26% | 加仓 |
| Spruce Street Capital LP |
| 11.52% | 8.81% | #1 | $5,871.1万 | 91.8万股 | $3,664.5万 | 76.1万股 | +15.7万股+20.63% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #92 | $5,593.7万 | 87.5万股 | $3,908.6万 | 81.2万股 | +6.3万股+7.74% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #124 | $4,942.1万 | 77.3万股 | $133.2万 | 2.8万股 | +74.5万股+2,694.35% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.27% | 0.22% | #28 | $4,592.9万 | 71.8万股 | $2,943.9万 | 61.1万股 | +10.7万股+17.47% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #175 | $4,503.3万 | 70.4万股 | $369.0万 | 7.7万股 | +62.8万股+818.92% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.05% | 0.09% | #50 | $4,342.7万 | 67.9万股 | $6,431.9万 | 133.6万股 | -65.7万股-49.18% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.05% | 0.04% | #52 | $4,217.5万 | 65.9万股 | $3,086.2万 | 64.1万股 | +1.9万股+2.89% | 加仓 |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 1.95% | 1.63% | #5 | $3,996.4万 | 62.5万股 | $2,929.5万 | 60.8万股 | +1.7万股+2.71% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.04% | 0.03% | #58 | $3,892.3万 | 60.9万股 | $3,001.1万 | 62.3万股 | -1.5万股-2.35% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #151 | $3,863.4万 | 60.4万股 | $213.1万 | 4.4万股 | +56.0万股+1,263.22% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #82 | $3,747.2万 | 58.6万股 | $0 | 0股 | +58.6万股 | 新买入 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.07% | 0.07% | #43 | $3,661.8万 | 57.3万股 | $3,128.0万 | 65.0万股 | -7.7万股-11.86% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.02% | 0.03% | #79 | $3,643.6万 | 57.0万股 | $4,618.8万 | 95.9万股 | -39.0万股-40.60% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.03% | 0.02% | #65 | $3,590.7万 | 56.1万股 | $2,026.7万 | 42.1万股 | +14.1万股+33.40% | 加仓 |
| 胜利资本管理VICTORY CAPITAL MANAGEMENT INC |
| 0.02% | 0.02% | #77 | $3,228.5万 | 50.5万股 | $2,438.9万 | 50.7万股 | -1,668股-0.33% | 减仓 |
| SG Americas Securities, LLC |
| 0.02% | 0.03% | #81 | $3,223.1万 | 50.4万股 | $3,082.5万 | 64.0万股 | -13.6万股-21.27% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.02% | #87 | $2,795.8万 | 43.7万股 | $3,118.8万 | 64.8万股 | -21.1万股-32.50% | 减仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #98 | $2,758.3万 | 43.1万股 | $2,109.0万 | 43.8万股 | -6,678股-1.52% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.51% | 0.17% | #16 | $2,689.7万 | 42.1万股 | $869.6万 | 18.1万股 | +24.0万股+132.89% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #97 | $2,677.9万 | 55.6万股 | $2,470.4万 | 59.9万股 | -4.3万股-7.14% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #161 | $2,643.8万 | 41.3万股 | $3,543.6万 | 73.6万股 | -32.3万股-43.83% | 减仓 |
| 奥伯维斯资产管理OBERWEIS ASSET MANAGEMENT INC/ |
| 0.55% | 0.45% | #13 | $2,641.4万 | 41.3万股 | $1,534.2万 | 31.9万股 | +9.4万股+29.63% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.04% | 0.03% | #59 | $2,580.3万 | 40.3万股 | $1,799.0万 | 37.4万股 | +3.0万股+7.99% | 加仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.01% | 0.01% | #104 | $2,546.9万 | 39.8万股 | $2,065.5万 | 42.9万股 | -3.1万股-7.16% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| 0.01% | 0.01% | #105 | $2,478.7万 | 38.8万股 | $2,521.6万 | 52.4万股 | -13.6万股-25.99% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #102 | $2,398.4万 | 37.5万股 | $1,823.4万 | 37.9万股 | -3,658股-0.97% | 减仓 |
| Penn Capital Management Company, LLC |
| 1.49% | 1.13% | #7 | $2,356.5万 | 36.8万股 | $1,455.7万 | 30.2万股 | +6.6万股+21.89% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.1% | 0.28% | #37 | $2,077.1万 | 32.5万股 | $4,812.1万 | 99.9万股 | -67.5万股-67.50% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #146 | $2,016.0万 | 31.5万股 | $177.8万 | 3.7万股 | +27.8万股+753.77% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.02% | 0.03% | #67 | $1,980.4万 | 31.0万股 | $2,406.5万 | 50.0万股 | -19.0万股-38.04% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.02% | 0.04% | #78 | $1,944.6万 | 30.4万股 | $3,307.2万 | 68.7万股 | -38.3万股-55.73% | 减仓 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| 0.02% | 0.01% | #69 | $1,743.1万 | 27.3万股 | $1,009.3万 | 21.0万股 | +6.3万股+30.04% | 加仓 |
| 野村控股NOMURA HOLDINGS INC |
| 0.02% | 0.04% | #70 | $1,731.3万 | 27.1万股 | $1,651.3万 | 34.3万股 | -7.2万股-21.06% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.54% | 1.02% | #15 | $1,575.4万 | 24.6万股 | $2,510.3万 | 52.1万股 | -27.5万股-52.75% | 减仓 |
| ESSEX INVESTMENT MANAGEMENT CO LLC |
| 2.02% | 1.9% | #4 | $1,543.6万 | 24.1万股 | $1,200.3万 | 24.9万股 | -7,896股-3.17% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #145 | $1,487.0万 | 23.3万股 | $83.7万 | 1.7万股 | +21.5万股+1,237.31% | 加仓 |
| ArrowMark Colorado Holdings LLC |
| 0.57% | 0.41% | #12 | $1,378.4万 | 21.6万股 | $1,526.1万 | 31.7万股 | -10.1万股-31.99% | 减仓 |
| STEMPOINT CAPITAL LP |
| 1.91% | — | #6 | $1,338.1万 | 20.9万股 | $0 | 0股 | +20.9万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #178 | $1,223.8万 | 19.1万股 | $842.1万 | 17.5万股 | +1.6万股+9.41% | 加仓 |
| SEI投资SEI INVESTMENTS CO |
| 0.01% | 0.01% | #90 | $1,205.9万 | 18.9万股 | $1,367.5万 | 28.4万股 | -9.5万股-33.61% | 减仓 |
| BRAIDWELL LP |
| 0.43% | 0.44% | #18 | $1,175.5万 | 18.4万股 | $1,312.2万 | 27.3万股 | -8.9万股-32.55% | 减仓 |
