| 富达投资FMR LLC |
| 0.02% | 0.03% | #48 | $5.51亿 | 3,092.4万股 | $5.50亿 | 3,078.6万股 | +13.8万股+0.45% | 加仓 |
| J. H. Whitney Equity Partners VI, LLC |
| 100% | 100% | #1 | $2.01亿 | 1,125.7万股 | $3.26亿 | 1,825.7万股 | -700.0万股-38.34% | 减仓 |
| Coatue管理COATUE MANAGEMENT LLC |
| 0.36% | 0.6% | #14 | $1.75亿 | 982.0万股 | $1.76亿 | 982.0万股 | 00.00% | 持仓不变 |
| BRAIDWELL LP |
| 5.44% | 4.78% | #3 | $1.47亿 | 825.6万股 | $1.43亿 | 800.9万股 | +24.7万股+3.08% | 加仓 |
| Sixth Street Partners Management Company, L.P. |
| 22.54% | 36.19% | #2 | $1.31亿 | 732.7万股 | $2.57亿 | 1,438.5万股 | -705.8万股-49.07% | 减仓 |
| 尖点州资本PointState Capital LP |
| 1.56% | 1.67% | #5 | $1.22亿 | 682.9万股 | $1.32亿 | 736.0万股 | -53.2万股-7.22% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| 0.01% | <0.01% | #84 | $1.20亿 | 655.9万股 | $5,830.5万 | 346.0万股 | +309.8万股+89.54% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #134 | $9,866.6万 | 553.7万股 | $8,684.5万 | 485.7万股 | +68.0万股+13.99% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.06% | 0.07% | #30 | $9,051.0万 | 507.9万股 | $9,991.9万 | 558.8万股 | -50.9万股-9.11% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #101 | $8,632.8万 | 484.4万股 | $6,720.1万 | 375.8万股 | +108.6万股+28.89% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #131 | $7,627.4万 | 428.0万股 | $5,952.3万 | 332.9万股 | +95.1万股+28.57% | 加仓 |
| 洛杉矶资本管理LOS ANGELES CAPITAL MANAGEMENT LLC |
| 0.26% | 0.16% | #16 | $7,054.1万 | 395.9万股 | $4,093.8万 | 229.0万股 | +166.9万股+72.89% | 加仓 |
| 纽伯格伯曼集团Neuberger Berman Group LLC |
| 0.04% | 0.05% | #37 | $6,399.1万 | 359.1万股 | $6,420.0万 | 359.1万股 | +377股+0.01% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.94% | 0.99% | #7 | $5,001.7万 | 280.7万股 | $5,018.6万 | 280.7万股 | 00.00% | 持仓不变 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #53 | $4,223.8万 | 237.0万股 | $2,886.3万 | 161.4万股 | +75.6万股+46.83% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #65 | $3,925.1万 | 220.3万股 | $2,731.6万 | 152.8万股 | +67.5万股+44.18% | 加仓 |
| MAK CAPITAL ONE LLC |
| 4.84% | — | #4 | $3,452.1万 | 193.7万股 | $0 | 0股 | +193.7万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #128 | $3,449.1万 | 193.6万股 | $4,641.6万 | 153.4万股 | +40.1万股+26.14% | 加仓 |
| 杜肯家族办公室Duquesne Family Office LLC |
| 0.65% | 1% | #10 | $3,375.9万 | 189.4万股 | $3,387.3万 | 189.4万股 | 00.00% | 持仓不变 |
| 清水投资Clearbridge Investments, LLC |
| 0.02% | 0.02% | #49 | $2,843.9万 | 159.6万股 | $2,774.6万 | 155.2万股 | +4.4万股+2.84% | 加仓 |
| FIL(富达国际)FIL Ltd |
| 0.02% | 0.02% | #54 | $2,760.2万 | 154.9万股 | $2,764.4万 | 154.6万股 | +2,827股+0.18% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | 0.01% | #107 | $2,536.4万 | 142.3万股 | $4,909.5万 | 274.6万股 | -132.2万股-48.16% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| 0.05% | — | #35 | $2,527.6万 | 141.8万股 | $0 | 0股 | +141.8万股 | 新买入 |
| 加拿大养老金计划投资委员会(CPPIB)CANADA PENSION PLAN INVESTMENT BOARD |
| 0.01% | 0.02% | #63 | $2,450.2万 | 137.5万股 | $2,365.1万 | 132.3万股 | +5.2万股+3.95% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #160 | $2,173.1万 | 121.8万股 | $1,761.1万 | 98.5万股 | +23.3万股+23.61% | 加仓 |
| 东方汇理Amundi |
| 0.01% | <0.01% | #89 | $2,171.1万 | 121.8万股 | $37.5万 | 2.1万股 | +119.7万股+5,709.48% | 加仓 |
| 资本世界投资者Capital World Investors |
| <0.01% | <0.01% | #113 | $2,162.1万 | 121.3万股 | $2,110.1万 | 118.0万股 | +3.3万股+2.80% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #120 | $2,148.0万 | 120.5万股 | $7,816.8万 | 437.2万股 | -316.6万股-72.43% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #139 | $2,139.5万 | 120.1万股 | $935.6万 | 52.3万股 | +67.7万股+129.44% | 加仓 |
| Champlain Investment 合伙人Champlain Investment Partners, LLC |
| 0.48% | 0.27% | #12 | $1,869.1万 | 104.9万股 | $2,159.8万 | 120.8万股 | -15.9万股-13.17% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #148 | $1,861.6万 | 104.5万股 | $1,392.0万 | 77.9万股 | +26.6万股+34.18% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #133 | $1,696.4万 | 95.2万股 | $733.7万 | 41.0万股 | +54.2万股+131.99% | 加仓 |
| ZEVENBERGEN CAPITAL 投资ZEVENBERGEN CAPITAL INVESTMENTS LLC |
| 0.33% | 0.31% | #15 | $1,429.3万 | 80.2万股 | $1,091.1万 | 61.0万股 | +19.2万股+31.44% | 加仓 |
| SEI投资SEI INVESTMENTS CO |
| 0.01% | 0.01% | #70 | $1,359.1万 | 76.3万股 | $1,070.5万 | 59.9万股 | +16.4万股+27.38% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.08% | 0.06% | #27 | $1,297.2万 | 72.8万股 | $877.1万 | 49.1万股 | +23.7万股+48.40% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.04% | 0.05% | #38 | $1,288.7万 | 72.3万股 | $1,293.0万 | 72.3万股 | 00.00% | 持仓不变 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | <0.01% | #91 | $1,168.4万 | 65.6万股 | $376.5万 | 21.1万股 | +44.5万股+211.33% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #112 | $1,077.1万 | 60.4万股 | $1,186.5万 | 66.4万股 | -5.9万股-8.92% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #122 | $1,020.7万 | 57.3万股 | $729.6万 | 40.8万股 | +16.5万股+40.36% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #154 | $1,017.4万 | 57.1万股 | $577.1万 | 32.3万股 | +24.8万股+76.89% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #61 | $1,012.2万 | 56.8万股 | $804.4万 | 45.0万股 | +11.8万股+26.25% | 加仓 |
| Rock Springs Capital Management LP |
| 0.42% | 0.59% | #13 | $868.7万 | 48.8万股 | $1,006.6万 | 56.3万股 | -7.6万股-13.41% | 减仓 |
| Quantinno资本管理Quantinno Capital Management LP |
| 0.01% | <0.01% | #74 | $787.1万 | 44.2万股 | $251.9万 | 14.1万股 | +30.1万股+213.44% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.03% | — | #45 | $756.3万 | 42.4万股 | $0 | 0股 | +42.4万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #153 | $703.3万 | 39.5万股 | $232.3万 | 13.0万股 | +26.5万股+203.79% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.01% | — | #79 | $678.8万 | 38.1万股 | $0 | 0股 | +38.1万股 | 新买入 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #86 | $676.1万 | 37.9万股 | $1,198.7万 | 67.0万股 | -29.1万股-43.41% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #150 | $549.6万 | 30.8万股 | $414.2万 | 23.2万股 | +7.7万股+33.13% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.01% | 0.01% | #80 | $508.9万 | 28.6万股 | $427.6万 | 23.9万股 | +4.6万股+19.42% | 加仓 |
| Picton Mahoney资产管理PICTON MAHONEY ASSET MANAGEMENT |
| 0.03% | 0.04% | #39 | $470.6万 | 26.4万股 | $498.8万 | 27.9万股 | -1.5万股-5.35% | 减仓 |
