| 范式生物资本Paradigm Biocapital Advisors LP |
| 6.76% | 4.37% | #2 | $3.61亿 | 1,313.3万股 | $2.14亿 | 796.8万股 | +516.5万股+64.83% | 加仓 |
| Orbis Allan GrayOrbis Allan Gray Ltd |
| 1.07% | 1.46% | #9 | $3.12亿 | 1,136.8万股 | $3.47亿 | 1,292.6万股 | -155.7万股-12.05% | 减仓 |
| 深轨资本Deep Track Capital, LP |
| 3.46% | 1.61% | #4 | $2.38亿 | 865.0万股 | $9,828.5万 | 366.3万股 | +498.7万股+136.13% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.08% | 0.1% | #28 | $2.32亿 | 864.5万股 | $2.94亿 | 955.7万股 | -91.2万股-9.55% | 减仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.97% | 0.78% | #6 | $1.89亿 | 686.5万股 | $6,605.5万 | 246.2万股 | +440.3万股+178.84% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.06% | 0.07% | #32 | $1.37亿 | 497.5万股 | $1.33亿 | 497.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #153 | $1.28亿 | 467.1万股 | $1.22亿 | 453.7万股 | +13.5万股+2.97% | 加仓 |
| Sofinnova Investments, Inc. |
| 5.74% | 0.77% | #3 | $1.11亿 | 404.5万股 | $2,018.3万 | 75.2万股 | +329.3万股+437.74% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.13% | 0.19% | #22 | $9,663.5万 | 351.8万股 | $1.18亿 | 441.5万股 | -89.7万股-20.31% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.07% | 0.05% | #30 | $9,633.3万 | 350.7万股 | $6,276.7万 | 233.9万股 | +116.7万股+49.90% | 加仓 |
| Harding LoevnerHARDING LOEVNER LP |
| 0.82% | 0.89% | #10 | $8,689.8万 | 308.6万股 | $8,670.4万 | 323.2万股 | -14.5万股-4.50% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #85 | $7,783.9万 | 283.4万股 | $462.8万 | 17.3万股 | +266.1万股+1,542.66% | 加仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.04% | 0.05% | #39 | $7,572.2万 | 275.7万股 | $6,603.8万 | 246.1万股 | +29.5万股+11.99% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.04% | 0.02% | #40 | $4,640.5万 | 168.9万股 | $1,817.3万 | 67.7万股 | +101.2万股+149.40% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #144 | $4,478.1万 | 163.0万股 | $5,135.9万 | 167.5万股 | -4.4万股-2.65% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.06% | 0.05% | #33 | $3,981.4万 | 144.9万股 | $3,358.0万 | 125.2万股 | +19.8万股+15.80% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #131 | $3,514.0万 | 127.9万股 | $2,498.6万 | 93.1万股 | +34.8万股+37.37% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #98 | $3,304.4万 | 120.3万股 | $3,201.2万 | 119.3万股 | +9,778股+0.82% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.03% | 0.03% | #48 | $2,928.1万 | 106.6万股 | $2,890.9万 | 107.7万股 | -1.2万股-1.07% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #127 | $2,640.0万 | 96.1万股 | $799.9万 | 29.8万股 | +66.3万股+222.36% | 加仓 |
| 永续有限公司Perpetual Ltd |
| 0.37% | 0.31% | #14 | $2,524.6万 | 91.9万股 | $2,035.1万 | 75.9万股 | +16.1万股+21.17% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #134 | $2,517.9万 | 91.7万股 | $2,550.3万 | 95.1万股 | -3.4万股-3.57% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #87 | $2,501.4万 | 91.1万股 | $2,125.7万 | 79.2万股 | +11.8万股+14.93% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.11% | — | #24 | $2,466.2万 | 89.8万股 | $0 | 0股 | +89.8万股 | 新买入 |
| 罗素投资集团Russell Investments Group, Ltd. |
| 0.02% | 0.02% | #54 | $2,426.8万 | 88.3万股 | $2,138.5万 | 79.7万股 | +8.6万股+10.83% | 加仓 |
| Envestnet资产管理ENVESTNET ASSET MANAGEMENT INC |
| 0.01% | 0.01% | #106 | $2,279.1万 | 83.0万股 | $2,313.6万 | 86.2万股 | -3.3万股-3.78% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.02% | <0.01% | #58 | $2,279.1万 | 83.0万股 | $40.2万 | 1.5万股 | +81.5万股+5,431.06% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.06% | 0.05% | #34 | $2,209.6万 | 80.4万股 | $1,731.8万 | 64.5万股 | +15.9万股+24.62% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #182 | $2,100.6万 | 76.5万股 | $2,714.5万 | 101.2万股 | -24.7万股-24.42% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #175 | $1,938.0万 | 74.5万股 | $575.0万 | 22.3万股 | +52.2万股+234.59% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.01% | 0.01% | #94 | $1,648.1万 | 60.0万股 | $1,446.0万 | 53.9万股 | +6.1万股+11.32% | 加仓 |
| CIBC世界市场CIBC WORLD MARKET INC. |
| 0.02% | 0.02% | #51 | $1,414.1万 | 51.5万股 | $1,310.0万 | 48.8万股 | +2.6万股+5.43% | 加仓 |
| 奥本海默资产管理OPPENHEIMER ASSET MANAGEMENT INC. |
| 0.13% | 0.14% | #23 | $1,229.1万 | 44.7万股 | $1,227.5万 | 45.8万股 | -1.0万股-2.20% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #179 | $1,200.6万 | 43.7万股 | $575.1万 | 21.4万股 | +22.3万股+103.91% | 加仓 |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 7.46% | 3.77% | #1 | $1,182.9万 | 43.1万股 | $527.8万 | 19.7万股 | +23.4万股+118.90% | 加仓 |
| 摩尔资本管理MOORE CAPITAL MANAGEMENT, LP |
| 0.17% | 0.12% | #21 | $1,155.1万 | 42.0万股 | $568.0万 | 21.2万股 | +20.9万股+98.62% | 加仓 |
| Dixon Mitchell Investment Counsel Inc. |
| 0.37% | — | #13 | $1,142.8万 | 41.6万股 | $0 | 0股 | +41.6万股 | 新买入 |
| Quantinno资本管理Quantinno Capital Management LP |
| 0.01% | 0.01% | #75 | $915.8万 | 33.3万股 | $757.9万 | 28.2万股 | +5.1万股+18.01% | 加仓 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| 0.02% | 0.03% | #49 | $906.5万 | 33.0万股 | $831.7万 | 31.0万股 | +2.0万股+6.45% | 加仓 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.23% | 0.07% | #16 | $874.7万 | 31.8万股 | $226.3万 | 8.4万股 | +23.4万股+277.47% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #164 | $834.1万 | 30.4万股 | $857.5万 | 32.0万股 | -1.6万股-4.99% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #194 | $792.4万 | 28.8万股 | $286.5万 | 10.7万股 | +18.2万股+170.10% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #209 | $712.2万 | 25.9万股 | $648.0万 | 24.2万股 | +1.8万股+7.34% | 加仓 |
| EAGLE GLOBAL 顾问EAGLE GLOBAL ADVISORS LLC |
| 0.22% | 0.24% | #17 | $672.3万 | 24.5万股 | $656.2万 | 24.5万股 | +165股+0.07% | 加仓 |
| AssetMarkASSETMARK, INC |
| 0.01% | 0.01% | #73 | $656.0万 | 23.9万股 | $601.4万 | 22.4万股 | +1.5万股+6.54% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #132 | $626.3万 | 22.8万股 | $610.6万 | 22.8万股 | +403股+0.18% | 加仓 |
| FOLKETRYGDFONDET |
| 0.1% | 0.08% | #26 | $453.5万 | 16.5万股 | $431.4万 | 16.1万股 | +4,309股+2.68% | 加仓 |
| Tidal投资Tidal Investments LLC |
| 0.01% | 0.01% | #91 | $446.1万 | 16.2万股 | $494.0万 | 18.4万股 | -2.2万股-11.81% | 减仓 |
| AIMZ Investment Advisors, LLC |
| 1.22% | 1.33% | #7 | $442.0万 | 16.1万股 | $431.7万 | 16.1万股 | 00.00% | 持仓不变 |
| LPL金融LPL Financial LLC |
| <0.01% | <0.01% | #183 | $396.5万 | 14.4万股 | $506.1万 | 18.9万股 | -4.4万股-23.49% | 减仓 |
