| ARK投资管理ARK Investment Management LLC |
| 1.85% | 1.45% | #3 | $2.86亿 | 1,687.6万股 | $1.86亿 | 1,450.9万股 | +236.6万股+16.31% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #131 | $2.61亿 | 1,540.9万股 | $1.56亿 | 1,215.6万股 | +325.3万股+26.76% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #124 | $1.56亿 | 923.5万股 | $8,874.9万 | 692.3万股 | +231.2万股+33.40% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #116 | $1.24亿 | 733.2万股 | $7,978.3万 | 622.3万股 | +110.9万股+17.82% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.05% | 0.04% | #52 | $1.09亿 | 644.3万股 | $7,343.5万 | 572.8万股 | +71.5万股+12.48% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #167 | $1.02亿 | 602.9万股 | $6,517.8万 | 508.4万股 | +94.4万股+18.58% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.05% | #45 | $8,858.2万 | 523.5万股 | $6,033.0万 | 470.6万股 | +52.9万股+11.25% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #138 | $8,076.0万 | 477.3万股 | $2,650.2万 | 206.7万股 | +270.6万股+130.89% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.67% | — | #11 | $7,659.6万 | 452.7万股 | $0 | 0股 | +452.7万股 | 新买入 |
| REGENERON PHARMACEUTICALS, INC. |
| 35.35% | 99.14% | #1 | $6,265.5万 | 370.3万股 | $4,747.2万 | 370.3万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #143 | $6,144.9万 | 363.1万股 | $3,656.3万 | 285.1万股 | +78.0万股+27.34% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | 0.01% | #76 | $5,551.0万 | 328.1万股 | $1,791.3万 | 139.7万股 | +188.4万股+134.80% | 加仓 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| 0.03% | 0.02% | #72 | $4,902.6万 | 289.8万股 | $2,529.5万 | 197.3万股 | +92.4万股+46.85% | 加仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 0.63% | 0.36% | #12 | $4,902.6万 | 289.8万股 | $2,527.5万 | 197.3万股 | +92.4万股+46.85% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #104 | $4,403.9万 | 260.3万股 | $2,970.9万 | 231.8万股 | +28.5万股+12.29% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #118 | $4,139.5万 | 244.7万股 | $4,177.1万 | 325.8万股 | -81.2万股-24.91% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #141 | $3,831.5万 | 226.4万股 | $2,087.4万 | 162.8万股 | +63.6万股+39.07% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #148 | $3,645.4万 | 215.4万股 | $3,464.8万 | 270.3万股 | -54.8万股-20.28% | 减仓 |
| Voloridge投资管理VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.15% | 0.08% | #32 | $3,496.3万 | 206.6万股 | $2,066.0万 | 161.2万股 | +45.5万股+28.22% | 加仓 |
| Contrarius Group Holdings Ltd |
| 1.52% | 1.39% | #5 | $3,308.2万 | 195.5万股 | $2,451.0万 | 191.2万股 | +4.3万股+2.27% | 加仓 |
| 木星资产管理JUPITER ASSET MANAGEMENT LTD |
| 0.16% | 0.12% | #30 | $3,129.4万 | 185.0万股 | $2,283.3万 | 178.1万股 | +6.8万股+3.84% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | 0.01% | #180 | $2,930.4万 | 173.2万股 | $1.04亿 | 602.3万股 | -429.1万股-71.24% | 减仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 0.31% | 0.08% | #19 | $2,538.0万 | 150.0万股 | $430.8万 | 33.6万股 | +116.4万股+346.43% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | — | #64 | $2,368.8万 | 140.0万股 | $0 | 0股 | +140.0万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #155 | $2,152.5万 | 127.2万股 | $1,238.8万 | 96.6万股 | +30.6万股+31.65% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| 0.04% | 0.02% | #60 | $2,103.7万 | 124.3万股 | $643.9万 | 50.2万股 | +74.1万股+147.51% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #151 | $2,043.8万 | 120.8万股 | $1,206.7万 | 94.1万股 | +26.7万股+28.33% | 加仓 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.12% | — | #34 | $2,030.4万 | 120.0万股 | $0 | 0股 | +120.0万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.06% | 0.01% | #50 | $1,819.5万 | 107.5万股 | $257.7万 | 20.1万股 | +87.4万股+435.00% | 加仓 |
| Stifel金融STIFEL FINANCIAL CORP |
| 0.01% | 0.01% | #87 | $1,716.3万 | 101.4万股 | $1,298.3万 | 101.3万股 | +1,681股+0.17% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #199 | $1,651.8万 | 97.6万股 | $1,771.3万 | 138.2万股 | -40.5万股-29.35% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.08% | — | #44 | $1,574.0万 | 93.0万股 | $0 | 0股 | +93.0万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #139 | $1,558.5万 | 92.1万股 | $959.1万 | 74.8万股 | +17.3万股+23.13% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.03% | 0.02% | #69 | $1,521.0万 | 89.9万股 | $959.8万 | 74.9万股 | +15.0万股+20.08% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #181 | $1,334.7万 | 78.9万股 | $1,432.8万 | 111.8万股 | -32.9万股-29.42% | 减仓 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.84% | 0.71% | #9 | $1,316.3万 | 77.8万股 | $928.5万 | 72.4万股 | +5.4万股+7.41% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.04% | <0.01% | #56 | $1,228.5万 | 72.6万股 | $76.9万 | 6.0万股 | +66.6万股+1,110.44% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.02% | 0.01% | #83 | $1,228.3万 | 72.6万股 | $472.6万 | 36.9万股 | +35.7万股+96.94% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #144 | $1,183.4万 | 69.9万股 | $739.6万 | 57.7万股 | +12.2万股+21.23% | 加仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #176 | $1,139.4万 | 67.3万股 | $596.8万 | 46.5万股 | +20.8万股+44.65% | 加仓 |
| Marex集团Marex Group plc |
| 0.04% | 0.05% | #54 | $1,055.1万 | 62.4万股 | $799.5万 | 62.4万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #212 | $1,025.6万 | 60.6万股 | $1,732.1万 | 135.1万股 | -74.5万股-55.14% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #123 | $977.7万 | 57.8万股 | $742.8万 | 57.9万股 | -1,605股-0.28% | 减仓 |
| Caption管理Caption Management, LLC |
| 0.04% | 0.04% | #55 | $952.1万 | 56.3万股 | $749.8万 | 58.5万股 | -2.2万股-3.80% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #96 | $917.3万 | 54.2万股 | $380.8万 | 29.7万股 | +24.5万股+82.54% | 加仓 |
| Vestmark顾问方案Vestmark Advisory Solutions, Inc. |
| 0.08% | 0.08% | #43 | $901.5万 | 53.3万股 | $705.3万 | 55.0万股 | -1.7万股-3.15% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #243 | $886.7万 | 52.8万股 | $639.0万 | 54.8万股 | -2.1万股-3.80% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #147 | $834.1万 | 49.3万股 | $808.3万 | 63.1万股 | -13.8万股-21.82% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #149 | $831.2万 | 49.1万股 | $90.5万 | 7.1万股 | +42.1万股+596.19% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #236 | $697.1万 | 41.2万股 | $557.4万 | 43.5万股 | -2.3万股-5.23% | 减仓 |
