| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 1.83% | 1.16% | #3 | $6.43亿 | 2,999.4万股 | $4.16亿 | 2,999.4万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #134 | $3.25亿 | 1,513.9万股 | $1.85亿 | 1,330.3万股 | +183.6万股+13.80% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #168 | $1.37亿 | 640.4万股 | $8,458.7万 | 609.4万股 | +30.9万股+5.08% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.01% | #83 | $1.27亿 | 591.1万股 | $5,354.1万 | 385.7万股 | +205.4万股+53.25% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #128 | $1.17亿 | 547.6万股 | $6,234.2万 | 449.1万股 | +98.5万股+21.93% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.05% | 0.02% | #58 | $9,922.5万 | 462.6万股 | $2,728.3万 | 196.6万股 | +266.0万股+135.34% | 加仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.3% | 0.32% | #20 | $9,154.1万 | 426.8万股 | $7,546.2万 | 543.7万股 | -116.9万股-21.50% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #147 | $7,813.1万 | 364.2万股 | $5,047.7万 | 363.6万股 | +5,783股+0.16% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #182 | $7,418.2万 | 345.8万股 | $4,479.4万 | 322.7万股 | +23.1万股+7.16% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | <0.01% | #112 | $6,715.0万 | 313.1万股 | $313.7万 | 22.6万股 | +290.5万股+1,285.29% | 加仓 |
| 景顺Invesco Ltd. |
| 0.01% | 0.01% | #131 | $6,636.7万 | 309.4万股 | $6,176.7万 | 445.0万股 | -135.6万股-30.47% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #127 | $6,401.2万 | 298.4万股 | $4,500.0万 | 324.2万股 | -25.8万股-7.95% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #124 | $5,717.1万 | 266.5万股 | $2,174.1万 | 156.6万股 | +109.9万股+70.18% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.31% | 0.18% | #19 | $5,421.9万 | 252.8万股 | $2,429.8万 | 175.1万股 | +77.7万股+44.39% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | 0.01% | #78 | $5,415.3万 | 252.5万股 | $2,769.3万 | 199.5万股 | +52.9万股+26.53% | 加仓 |
| LORD, ABBETT & CO. LLC |
| 0.15% | 0.16% | #33 | $5,308.5万 | 247.5万股 | $4,908.1万 | 353.6万股 | -106.1万股-30.01% | 减仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #93 | $5,075.4万 | 236.6万股 | $1,810.2万 | 130.4万股 | +106.2万股+81.43% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.05% | — | #59 | $4,681.1万 | 218.2万股 | $0 | 0股 | +218.2万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #156 | $4,651.6万 | 216.9万股 | $280.8万 | 20.2万股 | +196.6万股+971.87% | 加仓 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.15% | 0.13% | #34 | $4,487.9万 | 209.2万股 | $2,863.6万 | 206.3万股 | +2.9万股+1.41% | 加仓 |
| ARK投资管理ARK Investment Management LLC |
| 0.29% | 0.23% | #21 | $4,483.7万 | 209.0万股 | $2,905.0万 | 209.3万股 | -2,663股-0.13% | 减仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.06% | 0.04% | #47 | $4,052.3万 | 188.9万股 | $2,611.1万 | 188.1万股 | +8,005股+0.43% | 加仓 |
| Aristotle Atlantic Partners, LLC |
| 1.64% | 1.11% | #4 | $3,943.6万 | 183.9万股 | $2,379.5万 | 171.4万股 | +12.4万股+7.24% | 加仓 |
| 多伦多道明银行TORONTO DOMINION BANK |
| 0.04% | — | #60 | $3,861.0万 | 180.0万股 | $0 | 0股 | +180.0万股 | 新买入 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.03% | 0.01% | #77 | $3,817.4万 | 178.0万股 | $1,276.0万 | 91.9万股 | +86.0万股+93.59% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #178 | $3,710.9万 | 173.0万股 | $1,704.3万 | 122.8万股 | +50.2万股+40.89% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #169 | $3,527.9万 | 164.5万股 | $986.4万 | 71.1万股 | +93.4万股+131.43% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #152 | $3,233.3万 | 150.7万股 | $1,932.6万 | 139.2万股 | +11.5万股+8.26% | 加仓 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| 0.02% | 0.01% | #90 | $2,852.5万 | 133.0万股 | $2,214.4万 | 159.5万股 | -26.6万股-16.64% | 减仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 0.37% | 0.31% | #15 | $2,851.2万 | 133.0万股 | $2,214.4万 | 159.5万股 | -26.6万股-16.64% | 减仓 |
| 奥伯维斯资产管理OBERWEIS ASSET MANAGEMENT INC/ |
| 0.56% | 0.33% | #11 | $2,700.0万 | 125.9万股 | $1,120.0万 | 80.7万股 | +45.2万股+55.99% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.39% | 0.04% | #14 | $2,611.2万 | 121.7万股 | $211.7万 | 15.3万股 | +106.5万股+698.25% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #161 | $2,528.0万 | 117.9万股 | $1,590.2万 | 114.6万股 | +3.3万股+2.87% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | 0.01% | #135 | $2,333.2万 | 108.8万股 | $4,188.1万 | 301.7万股 | -193.0万股-63.95% | 减仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #118 | $2,299.3万 | 107.2万股 | $1,488.4万 | 107.2万股 | -396股-0.04% | 减仓 |
| Blue Water Life Science Advisors, LP |
| 13.65% | 11.24% | #1 | $2,166.8万 | 101.0万股 | $1,402.1万 | 101.0万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #140 | $2,005.0万 | 93.5万股 | $1,208.9万 | 87.1万股 | +6.4万股+7.32% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.03% | 0.02% | #76 | $1,971.3万 | 91.9万股 | $1,486.0万 | 107.1万股 | -15.2万股-14.16% | 减仓 |
| Freestone Grove合伙人Freestone Grove Partners LP |
| 0.12% | — | #37 | $1,891.2万 | 88.2万股 | $0 | 0股 | +88.2万股 | 新买入 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.32% | 0.27% | #18 | $1,822.8万 | 85.0万股 | $1,293.0万 | 93.2万股 | -8.2万股-8.77% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| 0.03% | <0.01% | #72 | $1,705.6万 | 79.5万股 | $182.1万 | 13.1万股 | +66.4万股+505.88% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.03% | 0.02% | #70 | $1,685.8万 | 78.6万股 | $901.7万 | 65.0万股 | +13.6万股+20.98% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.05% | 0.03% | #56 | $1,668.0万 | 77.8万股 | $716.1万 | 51.6万股 | +26.2万股+50.72% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #214 | $1,643.6万 | 76.6万股 | $1,603.8万 | 107.2万股 | -30.6万股-28.53% | 减仓 |
| Granite Investment Partners, LLC |
| 0.83% | 0.43% | #9 | $1,624.2万 | 75.7万股 | $694.1万 | 50.0万股 | +25.7万股+51.42% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.09% | 0.06% | #41 | $1,579.3万 | 73.6万股 | $793.4万 | 57.2万股 | +16.5万股+28.81% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #230 | $1,522.0万 | 71.0万股 | $787.0万 | 56.7万股 | +14.3万股+25.13% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.01% | 0.01% | #109 | $1,471.9万 | 68.6万股 | $1,045.3万 | 75.3万股 | -6.7万股-8.88% | 减仓 |
| Hillsdale Investment Management Inc. |
| 0.33% | 0.24% | #16 | $1,467.6万 | 68.4万股 | $867.8万 | 62.5万股 | +5.9万股+9.44% | 加仓 |
| NEXT CENTURY GROWTH INVESTORS LLC |
| 0.69% | 0.52% | #10 | $1,308.1万 | 61.0万股 | $700.0万 | 50.4万股 | +10.5万股+20.92% | 加仓 |
