| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #121 | $2.43亿 | 385.6万股 | $2.49亿 | 355.3万股 | +30.4万股+8.54% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 3.36% | 4.12% | #2 | $2.31亿 | 366.7万股 | $2.53亿 | 360.0万股 | +6.7万股+1.85% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 1.8% | 2.34% | #5 | $2.11亿 | 335.7万股 | $2.35亿 | 334.6万股 | +1.1万股+0.33% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.07% | — | #40 | $1.77亿 | 280.9万股 | $0 | 0股 | +280.9万股 | 新买入 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 3.27% | 3.67% | #3 | $1.75亿 | 277.6万股 | $1.80亿 | 256.2万股 | +21.3万股+8.33% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | 0.01% | #93 | $1.15亿 | 182.7万股 | $1.14亿 | 191.2万股 | -8.5万股-4.46% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #136 | $1.13亿 | 179.3万股 | $1.24亿 | 176.1万股 | +3.3万股+1.85% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.06% | 0.08% | #44 | $1.05亿 | 166.4万股 | $1.20亿 | 171.2万股 | -4.8万股-2.83% | 减仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 4.48% | 4.23% | #1 | $9,870.7万 | 156.8万股 | $8,338.2万 | 118.9万股 | +38.0万股+31.94% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.03% | 0.02% | #58 | $9,171.1万 | 145.7万股 | $4,171.0万 | 59.5万股 | +86.3万股+145.07% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #102 | $7,509.9万 | 119.3万股 | $8,378.6万 | 119.4万股 | -1,195股-0.10% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #116 | $6,960.6万 | 110.6万股 | $7,865.8万 | 112.1万股 | -1.5万股-1.37% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #141 | $6,753.2万 | 107.3万股 | $6,862.2万 | 97.8万股 | +9.5万股+9.68% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 1.54% | 0.39% | #6 | $6,608.7万 | 105.0万股 | $1,403.0万 | 20.0万股 | +85.0万股+425.00% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.07% | 0.14% | #39 | $5,963.5万 | 94.7万股 | $8,980.6万 | 128.0万股 | -33.3万股-25.99% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | 0.01% | #112 | $4,945.9万 | 78.6万股 | $5,208.6万 | 74.2万股 | +4.3万股+5.83% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #110 | $4,674.5万 | 74.3万股 | $3,084.0万 | 44.0万股 | +30.3万股+68.94% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 1% | 1.32% | #10 | $4,586.1万 | 72.9万股 | $5,111.4万 | 72.9万股 | 00.00% | 持仓不变 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.02% | 0.03% | #69 | $4,472.3万 | 71.1万股 | $5,549.9万 | 79.1万股 | -8.1万股-10.19% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #145 | $4,235.5万 | 67.3万股 | $5,144.3万 | 73.3万股 | -6.0万股-8.23% | 减仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.06% | 0.06% | #46 | $3,822.2万 | 60.7万股 | $3,506.5万 | 50.0万股 | +10.7万股+21.49% | 加仓 |
| 多伦多道明银行TORONTO DOMINION BANK |
| 0.04% | 0.05% | #56 | $3,507.4万 | 55.7万股 | $3,579.4万 | 51.0万股 | +4.7万股+9.21% | 加仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.03% | 0.03% | #60 | $3,457.8万 | 54.9万股 | $3,825.6万 | 54.5万股 | +4,036股+0.74% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.16% | 0.1% | #28 | $3,340.2万 | 53.1万股 | $1,658.7万 | 23.6万股 | +29.4万股+124.45% | 加仓 |
| LORD, ABBETT & CO. LLC |
| 0.09% | 0.19% | #36 | $3,016.5万 | 47.9万股 | $5,908.8万 | 84.2万股 | -36.3万股-43.10% | 减仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | — | #82 | $2,687.6万 | 42.7万股 | $0 | 0股 | +42.7万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #128 | $2,433.3万 | 38.7万股 | $2,476.0万 | 35.3万股 | +3.4万股+9.53% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #168 | $2,424.1万 | 38.5万股 | $2,356.3万 | 33.6万股 | +4.9万股+14.66% | 加仓 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.03% | 0.04% | #59 | $2,396.0万 | 38.1万股 | $2,861.0万 | 40.8万股 | -2.7万股-6.66% | 减仓 |
| 时代广场资本管理TimesSquare Capital Management, LLC |
| 0.34% | 0.46% | #16 | $2,324.9万 | 36.9万股 | $2,726.0万 | 38.9万股 | -1.9万股-4.94% | 减仓 |
| Wasatch顾问WASATCH ADVISORS LP |
| 0.15% | — | #29 | $2,319.8万 | 36.9万股 | $0 | 0股 | +36.9万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #129 | $2,113.7万 | 33.6万股 | $2,302.1万 | 32.8万股 | +7,672股+2.34% | 加仓 |
| Tri Locum Partners LP |
| 2.54% | 2.49% | #4 | $2,066.6万 | 32.8万股 | $1,771.9万 | 25.3万股 | +7.6万股+29.99% | 加仓 |
| MPM BioImpact LLC |
| 1.24% | 1.79% | #9 | $2,026.7万 | 32.2万股 | $2,313.2万 | 33.0万股 | -7,743股-2.35% | 减仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.12% | 0.48% | #31 | $1,998.8万 | 31.8万股 | $6,496.8万 | 92.6万股 | -60.9万股-65.71% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| 0.02% | 0.02% | #70 | $1,861.9万 | 29.6万股 | $1,690.8万 | 24.1万股 | +5.5万股+22.73% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #111 | $1,801.9万 | 28.6万股 | $1,913.3万 | 27.3万股 | +1.4万股+4.97% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | 0.01% | #117 | $1,800.1万 | 28.6万股 | $2,340.7万 | 33.4万股 | -4.8万股-14.29% | 减仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.03% | 0.03% | #62 | $1,793.2万 | 28.5万股 | $2,155.8万 | 30.7万股 | -2.2万股-7.29% | 减仓 |
| Rock Springs Capital Management LP |
| 0.85% | 0.93% | #13 | $1,744.0万 | 27.7万股 | $1,579.6万 | 22.5万股 | +5.2万股+23.05% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #142 | $1,725.4万 | 27.4万股 | $1,284.4万 | 18.3万股 | +9.1万股+49.72% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.03% | 0.04% | #63 | $1,691.2万 | 26.9万股 | $2,335.9万 | 33.3万股 | -6.4万股-19.31% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #158 | $1,679.2万 | 26.7万股 | $393.1万 | 5.6万股 | +21.1万股+376.11% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #147 | $1,641.4万 | 26.1万股 | $1,927.9万 | 27.5万股 | -1.4万股-5.10% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.01% | #94 | $1,269.0万 | 20.2万股 | $2,129.1万 | 30.4万股 | -10.2万股-33.57% | 减仓 |
| 麦肯齐金融MACKENZIE FINANCIAL CORP |
| 0.01% | — | #78 | $1,204.8万 | 19.1万股 | $0 | 0股 | +19.1万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #172 | $1,196.5万 | 19.0万股 | $1,346.9万 | 19.2万股 | -1,900股-0.99% | 减仓 |
| Parkman Healthcare Partners LLC |
| 0.97% | — | #11 | $944.1万 | 15.0万股 | $0 | 0股 | +15.0万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #192 | $868.4万 | 14.0万股 | $204.0万 | 3.0万股 | +11.0万股+359.29% | 加仓 |
| Allspring环球投资Allspring Global Investments Holdings, LLC |
| 0.01% | 0.02% | #76 | $793.6万 | 13.0万股 | $924.2万 | 13.2万股 | -1,283股-0.97% | 减仓 |
