| Avoro资本顾问Avoro Capital Advisors LLC |
| 2.78% | 0.96% | #11 | $3.10亿 | 672.8万股 | $9,743.9万 | 596.0万股 | +76.8万股+12.89% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| 0.01% | <0.01% | #109 | $2.31亿 | 486.8万股 | $4,179.6万 | 283.7万股 | +203.0万股+71.55% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 1.55% | 0.42% | #20 | $1.82亿 | 394.2万股 | $4,228.7万 | 258.6万股 | +135.5万股+52.40% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #112 | $1.61亿 | 349.5万股 | $5,958.3万 | 364.4万股 | -15.0万股-4.10% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #138 | $1.34亿 | 290.4万股 | $3,695.9万 | 226.1万股 | +64.3万股+28.46% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.18% | 0.14% | #53 | $1.31亿 | 284.8万股 | $8,675.9万 | 530.6万股 | -245.8万股-46.33% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #107 | $1.15亿 | 250.7万股 | $2,993.8万 | 183.1万股 | +67.6万股+36.93% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| 0.01% | <0.01% | #124 | $1.04亿 | 225.0万股 | $1,725.6万 | 105.5万股 | +119.4万股+113.16% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #179 | $8,647.5万 | 187.7万股 | $2,834.2万 | 173.3万股 | +14.4万股+8.31% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.4% | 0.24% | #41 | $8,492.1万 | 184.4万股 | $4,128.8万 | 252.5万股 | -68.2万股-26.99% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.57% | 0.69% | #19 | $8,325.3万 | 180.7万股 | $3,492.6万 | 213.6万股 | -32.9万股-15.39% | 减仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.04% | 0.01% | #84 | $7,191.9万 | 156.1万股 | $2,017.2万 | 123.4万股 | +32.8万股+26.55% | 加仓 |
| Boxer Capital Management, LLC |
| 5.21% | 1.42% | #5 | $6,924.2万 | 150.3万股 | $1,082.4万 | 66.2万股 | +84.1万股+127.08% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #133 | $6,798.3万 | 147.6万股 | $2,065.4万 | 126.3万股 | +21.3万股+16.84% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.05% | 0.04% | #81 | $6,734.1万 | 146.2万股 | $4,375.0万 | 267.6万股 | -121.4万股-45.36% | 减仓 |
| 两海资本Two Seas Capital LP |
| 1.31% | 0.3% | #22 | $6,639.1万 | 144.1万股 | $2,125.5万 | 130.0万股 | +14.1万股+10.88% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 2.17% | 1.71% | #16 | $6,527.4万 | 141.7万股 | $4,638.6万 | 283.7万股 | -142.0万股-50.05% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #155 | $5,849.9万 | 127.0万股 | $2,851.1万 | 174.4万股 | -47.4万股-27.17% | 减仓 |
| MAK CAPITAL ONE LLC |
| 7.95% | 1.06% | #3 | $5,674.8万 | 123.2万股 | $721.4万 | 44.1万股 | +79.1万股+179.25% | 加仓 |
| MPM BioImpact LLC |
| 3.44% | 1.73% | #7 | $5,646.3万 | 122.6万股 | $2,238.7万 | 136.9万股 | -14.3万股-10.47% | 减仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.07% | 0.01% | #71 | $4,980.0万 | 108.1万股 | $654.8万 | 40.1万股 | +68.1万股+169.96% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #154 | $4,912.9万 | 106.7万股 | $1,876.6万 | 32.2万股 | +74.5万股+231.77% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 1.01% | 0.16% | #25 | $4,306.6万 | 93.5万股 | $587.0万 | 35.9万股 | +57.6万股+160.45% | 加仓 |
| Maverick资本MAVERICK CAPITAL LTD |
| 0.38% | 0.13% | #43 | $4,262.3万 | 92.5万股 | $1,140.6万 | 69.8万股 | +22.8万股+32.64% | 加仓 |
| Fiera资本Fiera Capital Corp |
| 0.15% | 0.05% | #58 | $4,187.5万 | 90.9万股 | $1,335.6万 | 81.7万股 | +9.2万股+11.29% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 1.64% | 0.7% | #18 | $4,145.4万 | 90.0万股 | $1,471.5万 | 90.0万股 | 00.00% | 持仓不变 |
| 683 Capital Management, LLC |
| 2.02% | 1.5% | #17 | $4,104.9万 | 89.1万股 | $2,867.1万 | 175.4万股 | -86.2万股-49.18% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #168 | $3,965.8万 | 86.1万股 | $1,316.1万 | 80.5万股 | +5.6万股+6.96% | 加仓 |
| 花旗集团CITIGROUP INC |
| 0.01% | 0.02% | #113 | $3,749.0万 | 81.4万股 | $4,596.8万 | 281.1万股 | -199.8万股-71.05% | 减仓 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.81% | — | #29 | $3,706.0万 | 80.5万股 | $0 | 0股 | +80.5万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #194 | $3,591.7万 | 78.0万股 | $1,135.9万 | 69.5万股 | +8.5万股+12.24% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | — | #163 | $2,891.8万 | 62.8万股 | $0 | 0股 | +62.8万股 | 新买入 |
| First Turn Management, LLC |
| 3% | 1.12% | #10 | $2,804.7万 | 60.9万股 | $1,006.3万 | 61.5万股 | -6,564股-1.07% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.03% | — | #91 | $2,792.2万 | 60.6万股 | $0 | 0股 | +60.6万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.03% | 0.02% | #89 | $2,701.8万 | 58.7万股 | $1,576.6万 | 96.4万股 | -37.8万股-39.17% | 减仓 |
| Kinetic Partners 管理Kinetic Partners Management, LP |
| 0.64% | — | #33 | $2,676.1万 | 58.1万股 | $0 | 0股 | +58.1万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #172 | $2,665.9万 | 57.9万股 | $403.6万 | 24.7万股 | +33.2万股+134.47% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #125 | $2,500.7万 | 54.3万股 | $1,296.2万 | 79.3万股 | -25.0万股-31.51% | 减仓 |
| DIADEMA PARTNERS LP |
| 3.04% | 1.61% | #9 | $2,461.4万 | 53.4万股 | $948.6万 | 58.0万股 | -4.6万股-7.89% | 减仓 |
| 吉尔德·加尼翁·豪GILDER GAGNON HOWE & CO LLC |
| 0.25% | — | #49 | $2,445.7万 | 53.1万股 | $0 | 0股 | +53.1万股 | 新买入 |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. |
| 1.32% | 0.72% | #21 | $2,402.8万 | 52.2万股 | $852.9万 | 52.2万股 | 00.00% | 持仓不变 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.03% | <0.01% | #92 | $2,365.3万 | 51.4万股 | $239.9万 | 14.7万股 | +36.7万股+249.94% | 加仓 |
| READYSTATE 资产管理READYSTATE ASSET MANAGEMENT LP |
| 1.18% | 0.37% | #23 | $2,321.6万 | 50.5万股 | $825.2万 | 50.5万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #150 | $2,153.6万 | 46.8万股 | $822.1万 | 50.3万股 | -3.5万股-7.01% | 减仓 |
| Voss Capital, LP |
| 0.96% | 0.57% | #27 | $2,074.4万 | 45.0万股 | $1,070.9万 | 65.5万股 | -20.5万股-31.24% | 减仓 |
| Rubric资本管理Rubric Capital Management LP |
| 0.17% | — | #54 | $1,881.9万 | 40.9万股 | $0 | 0股 | +40.9万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #157 | $1,857.8万 | 40.3万股 | $614.5万 | 37.6万股 | +2.7万股+7.31% | 加仓 |
| Creek Drive Management Group LLC |
| 8.65% | 0.74% | #2 | $1,782.5万 | 38.7万股 | $327.0万 | 20.0万股 | +18.7万股+93.50% | 加仓 |
| Affinity Asset Advisors, LLC |
| 0.78% | 0.25% | #30 | $1,727.3万 | 37.5万股 | $490.5万 | 30.0万股 | +7.5万股+25.00% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #140 | $1,702.4万 | 37.0万股 | $543.7万 | 33.3万股 | +3.7万股+11.15% | 加仓 |
