| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 5.96% | 7.42% | #3 | $3.26亿 | 1,243.7万股 | $2.90亿 | 1,232.7万股 | +11.0万股+0.89% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #134 | $2.77亿 | 1,054.5万股 | $2.17亿 | 920.0万股 | +134.5万股+14.62% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 5.64% | 5.99% | #4 | $2.59亿 | 987.5万股 | $2.33亿 | 987.5万股 | 00.00% | 持仓不变 |
| Rubric资本管理Rubric Capital Management LP |
| 1.99% | 2.06% | #5 | $2.17亿 | 827.2万股 | $1.95亿 | 827.2万股 | 00.00% | 持仓不变 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.41% | 0.47% | #19 | $1.73亿 | 660.7万股 | $1.34亿 | 566.7万股 | +94.0万股+16.59% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | 0.01% | #126 | $1.53亿 | 582.3万股 | $1.48亿 | 629.6万股 | -47.3万股-7.52% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #155 | $1.31亿 | 498.9万股 | $1.15亿 | 487.2万股 | +11.7万股+2.41% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #113 | $1.17亿 | 445.1万股 | $8,061.0万 | 427.6万股 | +17.5万股+4.08% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.07% | 0.08% | #46 | $1.11亿 | 421.9万股 | $1.17亿 | 498.1万股 | -76.2万股-15.29% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.05% | 0.04% | #53 | $1.04亿 | 395.0万股 | $5,881.1万 | 249.6万股 | +145.3万股+58.22% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #93 | $8,739.2万 | 333.3万股 | $7,843.7万 | 332.9万股 | +3,791股+0.11% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #119 | $7,833.0万 | 298.7万股 | $5,233.4万 | 222.1万股 | +76.6万股+34.49% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #132 | $7,821.4万 | 298.2万股 | $7,175.9万 | 304.5万股 | -6.3万股-2.06% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #154 | $6,368.9万 | 242.9万股 | $4,605.2万 | 195.5万股 | +47.4万股+24.27% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.01% | — | #11 | $5,354.1万 | 204.2万股 | $0 | 0股 | +204.2万股 | 新买入 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #97 | $5,063.0万 | 193.1万股 | $5,414.0万 | 229.8万股 | -36.7万股-15.97% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #72 | $5,047.4万 | 192.5万股 | $3,447.4万 | 146.3万股 | +46.2万股+31.56% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #138 | $4,374.5万 | 166.8万股 | $3,776.7万 | 160.3万股 | +6.5万股+4.08% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.02% | — | #82 | $3,698.9万 | 141.0万股 | $0 | 0股 | +141.0万股 | 新买入 |
| 奥伯维斯资产管理OBERWEIS ASSET MANAGEMENT INC/ |
| 0.74% | 0.95% | #14 | $3,599.9万 | 137.3万股 | $3,218.2万 | 136.6万股 | +7,000股+0.51% | 加仓 |
| 吉尔德·加尼翁·豪GILDER GAGNON HOWE & CO LLC |
| 0.36% | 1.22% | #21 | $3,443.2万 | 131.3万股 | $1.01亿 | 430.4万股 | -299.1万股-69.49% | 减仓 |
| GW&K Investment Management, LLC |
| 0.26% | 0.21% | #24 | $3,377.2万 | 128.8万股 | $2,328.6万 | 98.8万股 | +30.0万股+30.32% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #137 | $3,326.3万 | 126.9万股 | $231.4万 | 9.8万股 | +117.0万股+1,191.79% | 加仓 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 10.78% | 11.42% | #1 | $3,317.6万 | 126.5万股 | $3,194.5万 | 135.6万股 | -9.1万股-6.68% | 减仓 |
| BAMCO(巴伦基金)BAMCO INC /NY/ |
| 0.05% | 0.08% | #52 | $3,285.7万 | 125.3万股 | $2,526.1万 | 107.2万股 | +18.1万股+16.87% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.04% | 0.04% | #55 | $2,948.8万 | 112.5万股 | $2,538.0万 | 107.7万股 | +4.7万股+4.40% | 加仓 |
| 永续有限公司Perpetual Ltd |
| 0.42% | 0.33% | #18 | $2,909.5万 | 111.0万股 | $2,142.9万 | 91.0万股 | +20.0万股+22.00% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.04% | 0.02% | #58 | $2,880.0万 | 109.8万股 | $1,519.8万 | 64.5万股 | +45.3万股+70.28% | 加仓 |
| Jones Hill Capital LP |
| 6.07% | — | #2 | $2,857.2万 | 109.0万股 | $0 | 0股 | +109.0万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #146 | $2,775.6万 | 105.9万股 | $2,300.7万 | 97.7万股 | +8.2万股+8.40% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #140 | $2,755.5万 | 105.1万股 | $2,385.6万 | 101.3万股 | +3.8万股+3.79% | 加仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.04% | 0.05% | #56 | $2,555.2万 | 97.5万股 | $2,931.8万 | 124.4万股 | -27.0万股-21.69% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.11% | 0.12% | #36 | $2,488.1万 | 95.0万股 | $2,332.4万 | 80.3万股 | +14.7万股+18.27% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.13% | 0.39% | #35 | $2,303.2万 | 87.8万股 | $5,244.5万 | 222.6万股 | -134.8万股-60.54% | 减仓 |
| 纽文Nuveen, LLC |
| 0.01% | 0.01% | #117 | $2,187.4万 | 83.4万股 | $2,125.4万 | 90.2万股 | -6.8万股-7.52% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #125 | $2,137.3万 | 81.5万股 | $1,818.3万 | 77.2万股 | +4.3万股+5.62% | 加仓 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| 0.02% | 0.01% | #76 | $2,128.4万 | 81.2万股 | $1,187.1万 | 50.4万股 | +30.8万股+61.11% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | <0.01% | #88 | $1,740.7万 | 66.4万股 | $552.0万 | 23.4万股 | +43.0万股+183.34% | 加仓 |
| FISHMAN JAY A LTD/MI |
| 1.24% | 1.19% | #9 | $1,560.1万 | 59.5万股 | $1,335.2万 | 56.7万股 | +2.8万股+4.99% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #183 | $1,496.2万 | 57.1万股 | $626.2万 | 26.6万股 | +30.5万股+114.70% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #120 | $1,479.0万 | 56.4万股 | $116.2万 | 4.9万股 | +51.5万股+1,043.40% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.01% | #109 | $1,435.0万 | 54.7万股 | $1,913.4万 | 81.2万股 | -26.5万股-32.61% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| 0.02% | 0.03% | #78 | $1,410.0万 | 53.8万股 | $2,599.8万 | 110.3万股 | -56.6万股-51.27% | 减仓 |
| Capitolis全球市场CAPITOLIS LIQUID GLOBAL MARKETS LLC |
| 0.06% | 0.07% | #47 | $1,311.0万 | 50.0万股 | $1,178.0万 | 50.0万股 | 00.00% | 持仓不变 |
| 近水资本市场Nearwater Capital Markets, Ltd |
| 0.22% | 0.34% | #29 | $1,276.1万 | 48.7万股 | $1,430.8万 | 60.7万股 | -12.1万股-19.86% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | 0.01% | #75 | $1,221.9万 | 46.6万股 | $862.3万 | 36.6万股 | +10.0万股+27.32% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | 0.06% | #100 | $1,171.7万 | 44.7万股 | $5,729.3万 | 243.2万股 | -198.5万股-81.62% | 减仓 |
| Privium Fund Management B.V. |
| 1.92% | 1.57% | #6 | $1,047.1万 | 39.9万股 | $756.2万 | 32.1万股 | +7.8万股+24.42% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | <0.01% | #188 | $1,028.6万 | 39.2万股 | $1,062.5万 | 67.9万股 | -28.7万股-42.25% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #153 | $1,003.4万 | 38.3万股 | $918.5万 | 39.0万股 | -7,165股-1.84% | 减仓 |
