| 富达投资FMR LLC |
| 0.02% | 0.02% | #83 | $4.19亿 | 781.0万股 | $4.05亿 | 840.3万股 | -59.3万股-7.06% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.07% | #62 | $3.96亿 | 737.9万股 | $3.50亿 | 726.0万股 | +11.9万股+1.64% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 3.16% | 3.11% | #6 | $3.52亿 | 655.6万股 | $3.16亿 | 655.6万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.11% | — | #53 | $2.79亿 | 520.4万股 | $0 | 0股 | +520.4万股 | 新买入 |
| 深轨资本Deep Track Capital, LP |
| 3.7% | 3.37% | #4 | $2.54亿 | 474.0万股 | $2.06亿 | 428.0万股 | +46.0万股+10.75% | 加仓 |
| BVF INC/IL |
| 4.62% | 5.31% | #2 | $1.81亿 | 336.7万股 | $1.67亿 | 345.9万股 | -9.3万股-2.67% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #96 | $1.51亿 | 280.7万股 | $1,617.7万 | 57.8万股 | +222.9万股+385.80% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 2.24% | 1.41% | #10 | $1.19亿 | 220.9万股 | $7,111.4万 | 147.5万股 | +73.4万股+49.75% | 加仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.05% | 0.05% | #68 | $9,407.0万 | 175.3万股 | $8,453.1万 | 175.4万股 | -1,011股-0.06% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.04% | 0.04% | #70 | $9,028.3万 | 168.2万股 | $6,931.3万 | 143.8万股 | +24.4万股+16.98% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.74% | — | #21 | $8,627.5万 | 160.8万股 | $0 | 0股 | +160.8万股 | 新买入 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.48% | 0.56% | #28 | $8,336.1万 | 155.3万股 | $7,602.9万 | 157.7万股 | -2.4万股-1.53% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.39% | 0.4% | #33 | $7,688.4万 | 143.3万股 | $6,904.8万 | 143.3万股 | 00.00% | 持仓不变 |
| Casdin Capital, LLC |
| 3.16% | 4.29% | #7 | $6,306.2万 | 117.5万股 | $5,663.5万 | 117.5万股 | 00.00% | 持仓不变 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.61% | 0.44% | #24 | $5,828.6万 | 108.6万股 | $3,701.7万 | 76.8万股 | +31.8万股+41.41% | 加仓 |
| Capitolis全球市场CAPITOLIS LIQUID GLOBAL MARKETS LLC |
| 0.24% | 0.35% | #40 | $5,587.6万 | 104.1万股 | $5,549.3万 | 115.1万股 | -11.0万股-9.57% | 减仓 |
| Siren, L.L.C. |
| 0.95% | 1.78% | #19 | $4,685.2万 | 87.3万股 | $6,404.3万 | 132.9万股 | -45.6万股-34.30% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | 0.01% | #109 | $4,538.0万 | 84.6万股 | $9,643.4万 | 200.1万股 | -115.5万股-57.74% | 减仓 |
| PACIFIC HEIGHTS 资产管理PACIFIC HEIGHTS ASSET MANAGEMENT LLC |
| 1.36% | 1.21% | #14 | $4,293.6万 | 80.0万股 | $3,615.0万 | 75.0万股 | +5.0万股+6.67% | 加仓 |
| Rock Springs Capital Management LP |
| 1.68% | 1.82% | #11 | $3,436.6万 | 64.0万股 | $3,085.8万 | 64.0万股 | +100股+0.02% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.05% | 0.03% | #67 | $3,434.4万 | 64.0万股 | $1,888.5万 | 39.2万股 | +24.8万股+63.32% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #100 | $3,106.6万 | 57.9万股 | $2,562.3万 | 53.2万股 | +4.7万股+8.89% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #129 | $3,023.9万 | 56.3万股 | $1,094.8万 | 22.7万股 | +33.6万股+148.06% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.01% | 0.01% | #93 | $2,948.4万 | 61.2万股 | $4,442.9万 | 63.9万股 | -2.7万股-4.24% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #160 | $2,743.3万 | 51.1万股 | $2,130.3万 | 44.2万股 | +6.9万股+15.65% | 加仓 |
| Logos Global Management LP |
| 1.16% | 1.2% | #18 | $2,683.5万 | 50.0万股 | $2,410.0万 | 50.0万股 | 00.00% | 持仓不变 |
| Parkman Healthcare Partners LLC |
| 2.67% | 1.15% | #9 | $2,606.5万 | 48.6万股 | $1,118.7万 | 23.2万股 | +25.4万股+109.25% | 加仓 |
| Davern Capital Partners, LP |
| 4.08% | 1.67% | #3 | $2,394.0万 | 44.6万股 | $609.5万 | 12.6万股 | +32.0万股+252.72% | 加仓 |
| 安大略医疗养老基金(HOOPP)HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.03% | 0.04% | #74 | $2,247.7万 | 41.9万股 | $2,254.8万 | 46.8万股 | -4.9万股-10.47% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #131 | $2,081.3万 | 38.8万股 | $2,092.1万 | 43.4万股 | -4.6万股-10.66% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #122 | $2,034.0万 | 37.9万股 | $1,026.3万 | 21.3万股 | +16.6万股+78.00% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| 0.01% | 0.01% | #106 | $1,781.1万 | 33.2万股 | $1,599.6万 | 33.2万股 | 00.00% | 持仓不变 |
| NEXTBio Capital Management LP |
| 7.71% | 2.98% | #1 | $1,677.2万 | 31.2万股 | $642.2万 | 13.3万股 | +17.9万股+134.54% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #138 | $1,573.8万 | 29.3万股 | $1,831.8万 | 38.0万股 | -8.7万股-22.84% | 减仓 |
| Catalio Capital Management, LP |
| 2.79% | 2.57% | #8 | $1,484.2万 | 27.7万股 | $1,230.9万 | 25.5万股 | +2.1万股+8.29% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.01% | <0.01% | #89 | $1,436.2万 | 26.8万股 | $333.1万 | 6.9万股 | +19.8万股+287.21% | 加仓 |
| HSG Holding Ltd |
| 1.19% | 0.38% | #16 | $1,428.0万 | 26.6万股 | $620.5万 | 26.6万股 | 00.00% | 持仓不变 |
| SEB资产管理SEB Asset Management AB |
| 0.05% | 0.05% | #66 | $1,315.1万 | 24.5万股 | $1,181.1万 | 24.5万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #125 | $1,237.2万 | 23.1万股 | $1,058.1万 | 22.0万股 | +1.1万股+5.01% | 加仓 |
| 加拿大国家银行NATIONAL BANK OF CANADA /FI/ |
| 0.01% | 0.01% | #92 | $1,158.2万 | 21.6万股 | $1,472.0万 | 30.5万股 | -9.0万股-29.34% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #97 | $1,095.7万 | 20.4万股 | $874.4万 | 18.1万股 | +2.3万股+12.54% | 加仓 |
| Eversept Partners, LP |
| 0.55% | 0.35% | #27 | $1,053.6万 | 19.6万股 | $665.3万 | 13.8万股 | +5.8万股+42.21% | 加仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| 0.04% | 0.06% | #73 | $1,023.4万 | 19.1万股 | $797.4万 | 16.5万股 | +2.5万股+15.27% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.03% | 0.03% | #78 | $825.5万 | 15.4万股 | $919.7万 | 19.1万股 | -3.7万股-19.39% | 减仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.01% | 0.01% | #88 | $821.8万 | 15.3万股 | $646.0万 | 13.4万股 | +1.9万股+14.26% | 加仓 |
| ArrowMark Colorado Holdings LLC |
| 0.34% | 0.24% | #35 | $808.2万 | 15.1万股 | $907.1万 | 18.8万股 | -3.8万股-19.99% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.13% | 0.04% | #51 | $799.4万 | 14.9万股 | $291.7万 | 6.1万股 | +8.8万股+146.13% | 加仓 |
| CenterBook Partners LP |
| 0.39% | 0.05% | #32 | $794.5万 | 14.8万股 | $102.4万 | 2.1万股 | +12.7万股+597.04% | 加仓 |
| Rhenman & Partners Asset Management AB |
| 0.74% | 0.76% | #22 | $778.8万 | 14.5万股 | $617.4万 | 12.8万股 | +1.7万股+13.27% | 加仓 |
| B Group, Inc. |
| 3.53% | 4.56% | #5 | $751.4万 | 14.0万股 | $614.6万 | 12.8万股 | +1.3万股+9.80% | 加仓 |
