| RTW投资RTW INVESTMENTS, LP |
| 5.16% | 4.7% | #9 | $6.05亿 | 851.5万股 | $4.73亿 | 698.5万股 | +153.0万股+21.90% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.31% | 0.31% | #25 | $4.70亿 | 661.7万股 | $4.55亿 | 672.0万股 | -10.3万股-1.54% | 减仓 |
| Decheng Capital LLC |
| 61.87% | 65.21% | #1 | $4.53亿 | 637.2万股 | $4.31亿 | 637.2万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #102 | $4.45亿 | 625.6万股 | $3.43亿 | 506.4万股 | +119.2万股+23.54% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.07% | #43 | $3.78亿 | 532.5万股 | $3.64亿 | 537.1万股 | -4.6万股-0.87% | 减仓 |
| 富达投资FMR LLC |
| 0.01% | 0.01% | #75 | $2.96亿 | 416.1万股 | $2.55亿 | 376.5万股 | +39.7万股+10.54% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.03% | #61 | $2.70亿 | 380.5万股 | $2.47亿 | 365.3万股 | +15.2万股+4.16% | 加仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 6.27% | 7.11% | #8 | $2.61亿 | 367.0万股 | $2.48亿 | 367.0万股 | 00.00% | 持仓不变 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #82 | $2.46亿 | 346.5万股 | $2.09亿 | 309.5万股 | +37.0万股+11.96% | 加仓 |
| Caption管理Caption Management, LLC |
| 1.15% | 1.09% | #14 | $2.46亿 | 345.9万股 | $1.87亿 | 275.9万股 | +70.0万股+25.37% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #100 | $2.44亿 | 343.8万股 | $1.79亿 | 264.7万股 | +79.1万股+29.86% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #113 | $2.36亿 | 331.7万股 | $2.05亿 | 303.4万股 | +28.3万股+9.33% | 加仓 |
| Foresite Capital Management VI LLC |
| 26.2% | 32.67% | #2 | $1.68亿 | 237.0万股 | $1.50亿 | 222.1万股 | +14.8万股+6.67% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #96 | $1.53亿 | 215.3万股 | $1.08亿 | 159.7万股 | +55.6万股+34.84% | 加仓 |
| EcoR1 Capital, LLC |
| 7.1% | 3.17% | #7 | $1.46亿 | 205.6万股 | $7,458.3万 | 110.2万股 | +95.4万股+86.55% | 加仓 |
| Seven Fleet Capital Management LP |
| 22.12% | 1.63% | #3 | $1.34亿 | 188.6万股 | $512.7万 | 7.6万股 | +181.0万股+2,389.82% | 加仓 |
| DV Trading LLC |
| 3.35% | 2.31% | #10 | $1.02亿 | 143.9万股 | $9,741.8万 | 143.9万股 | 00.00% | 持仓不变 |
| Avidity Partners Management LP |
| 15.92% | 17.67% | #6 | $9,939.5万 | 139.9万股 | $8,723.6万 | 128.9万股 | +11.0万股+8.53% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.02% | 0.02% | #68 | $9,328.0万 | 131.3万股 | $1.02亿 | 150.7万股 | -19.4万股-12.88% | 减仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.03% | 0.02% | #57 | $9,300.2万 | 137.4万股 | $5,356.4万 | 129.0万股 | +8.4万股+6.52% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #121 | $8,363.4万 | 117.7万股 | $2,587.6万 | 64.2万股 | +53.5万股+83.23% | 加仓 |
| ACORN CAPITAL ADVISORS, LLC |
| 21.94% | 21.77% | #4 | $8,039.3万 | 113.2万股 | $7,658.0万 | 113.1万股 | +999股+0.09% | 加仓 |
| Foresite Capital Management V, LLC |
| 21.17% | 25.08% | #5 | $7,666.7万 | 107.9万股 | $6,795.4万 | 100.4万股 | +7.5万股+7.47% | 加仓 |
| Logos Global Management LP |
| 3.06% | 1.94% | #11 | $7,105.0万 | 100.0万股 | $3,891.6万 | 57.5万股 | +42.5万股+73.91% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #118 | $6,997.8万 | 98.5万股 | $9,809.3万 | 144.9万股 | -46.4万股-32.04% | 减仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #93 | $6,946.5万 | 97.8万股 | $8,879.5万 | 131.2万股 | -33.4万股-25.48% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.3% | 1.27% | #13 | $6,911.7万 | 97.3万股 | $6,417.9万 | 94.8万股 | +2.5万股+2.59% | 加仓 |
| SG Americas Securities, LLC |
| 0.03% | <0.01% | #58 | $6,163.3万 | 86.7万股 | $166.7万 | 2.5万股 | +84.3万股+3,421.70% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #111 | $6,094.1万 | 85.8万股 | $7,845.7万 | 115.9万股 | -30.2万股-26.01% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #116 | $5,886.9万 | 82.9万股 | $2,928.5万 | 43.3万股 | +39.6万股+91.48% | 加仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.36% | — | #23 | $5,470.5万 | 77.0万股 | $0 | 0股 | +77.0万股 | 新买入 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | 0.01% | #88 | $5,412.6万 | 76.2万股 | $7,207.7万 | 106.5万股 | -30.3万股-28.47% | 减仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.04% | 0.04% | #49 | $5,227.4万 | 73.6万股 | $4,942.6万 | 73.0万股 | +5,453股+0.75% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | <0.01% | #67 | $5,159.3万 | 72.6万股 | $33.2万 | 4,907股 | +72.1万股+14,698.33% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | <0.01% | #108 | $4,816.6万 | 67.8万股 | $3,517.1万 | 52.0万股 | +15.8万股+30.45% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #106 | $4,456.1万 | 62.7万股 | $3,670.8万 | 54.2万股 | +8.5万股+15.64% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #95 | $3,824.5万 | 53.8万股 | $3,182.7万 | 47.0万股 | +6.8万股+14.47% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 0.74% | — | #16 | $3,507.0万 | 49.4万股 | $0 | 0股 | +49.4万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.11% | 0.13% | #35 | $3,502.0万 | 49.3万股 | $3,335.9万 | 49.3万股 | 00.00% | 持仓不变 |
| 康得利安资管Candriam S.C.A. |
| 0.15% | 0.17% | #30 | $3,330.2万 | 46.9万股 | $3,311.8万 | 79.8万股 | -32.8万股-41.18% | 减仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.01% | 0.01% | #90 | $3,246.8万 | 45.7万股 | $3,147.3万 | 46.5万股 | -8,055股-1.73% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #154 | $3,099.3万 | 41.8万股 | $3,579.1万 | 56.0万股 | -14.2万股-25.35% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #109 | $3,082.7万 | 43.4万股 | $2,968.9万 | 43.9万股 | -4,791股-1.09% | 减仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 0.13% | 0.26% | #31 | $2,842.0万 | 40.0万股 | $4,561.6万 | 67.4万股 | -27.4万股-40.65% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.04% | 0.04% | #52 | $2,774.2万 | 39.0万股 | $2,706.2万 | 40.0万股 | -9,400股-2.35% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.04% | 0.06% | #48 | $2,703.8万 | 38.1万股 | $3,086.3万 | 45.6万股 | -7.5万股-16.55% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.35% | 0.41% | #24 | $2,628.6万 | 37.0万股 | $2,502.7万 | 37.0万股 | -146股-0.04% | 减仓 |
| LORD, ABBETT & CO. LLC |
| 0.07% | 0.08% | #42 | $2,590.0万 | 36.5万股 | $2,302.5万 | 34.0万股 | +2.4万股+7.16% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.01% | 0.02% | #74 | $2,254.0万 | 31.7万股 | $3,222.5万 | 47.6万股 | -15.9万股-33.37% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.03% | 0.02% | #56 | $2,211.3万 | 31.1万股 | $1,006.7万 | 14.9万股 | +16.2万股+109.23% | 加仓 |
