| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #90 | $2.11亿 | 473.8万股 | $1.83亿 | 355.0万股 | +118.8万股+33.47% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.02% | #46 | $1.06亿 | 238.3万股 | $1.31亿 | 253.6万股 | -15.3万股-6.04% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #77 | $9,318.9万 | 208.9万股 | $8,444.5万 | 163.7万股 | +45.2万股+27.60% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 2.97% | 1.2% | #1 | $8,616.1万 | 193.1万股 | $2,972.6万 | 57.6万股 | +135.5万股+235.14% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.03% | 0.01% | #42 | $8,093.8万 | 185.7万股 | $1,592.1万 | 30.9万股 | +154.8万股+501.56% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | <0.01% | #60 | $7,340.6万 | 164.6万股 | $3,295.6万 | 63.9万股 | +100.7万股+157.54% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.03% | 0.04% | #38 | $6,559.7万 | 147.0万股 | $6,187.7万 | 120.0万股 | +27.1万股+22.58% | 加仓 |
| 野村控股NOMURA HOLDINGS INC |
| 0.07% | — | #21 | $6,108.9万 | 136.9万股 | $0 | 0股 | +136.9万股 | 新买入 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 0.6% | 1.64% | #5 | $5,785.3万 | 129.7万股 | $1.39亿 | 270.3万股 | -140.6万股-52.03% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #140 | $5,669.6万 | 127.1万股 | $6,533.8万 | 126.7万股 | +4,190股+0.33% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #121 | $5,382.2万 | 120.6万股 | $4,931.1万 | 95.6万股 | +25.0万股+26.20% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.05% | 0.04% | #32 | $3,856.1万 | 86.4万股 | $2,683.1万 | 52.0万股 | +34.4万股+66.17% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #113 | $3,529.6万 | 79.1万股 | $3,343.8万 | 45.1万股 | +34.1万股+75.58% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.05% | 0.06% | #29 | $3,266.9万 | 73.2万股 | $4,026.2万 | 78.1万股 | -4.8万股-6.18% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #118 | $3,127.0万 | 70.1万股 | $2,632.4万 | 51.0万股 | +19.1万股+37.36% | 加仓 |
| BRAIDWELL LP |
| 1.12% | 1.17% | #3 | $3,022.6万 | 67.8万股 | $3,494.9万 | 67.8万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #100 | $2,881.2万 | 64.6万股 | $3,424.9万 | 66.4万股 | -1.8万股-2.73% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #91 | $2,591.5万 | 58.1万股 | $2,491.7万 | 48.3万股 | +9.8万股+20.26% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | <0.01% | #74 | $2,435.8万 | 54.6万股 | $2,314.8万 | 44.9万股 | +9.7万股+21.67% | 加仓 |
| SG Americas Securities, LLC |
| 0.01% | 0.01% | #54 | $2,193.5万 | 49.2万股 | $542.3万 | 10.5万股 | +38.7万股+367.63% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | 0.01% | #61 | $1,909.6万 | 42.8万股 | $1,649.3万 | 32.0万股 | +10.8万股+33.87% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | 0.04% | #43 | $1,900.4万 | 42.6万股 | $2,424.1万 | 47.0万股 | -4.4万股-9.36% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.77% | 1.23% | #4 | $1,671.2万 | 37.5万股 | $2,090.0万 | 40.5万股 | -3.1万股-7.55% | 减仓 |
| 安本标准投资Aberdeen Group plc |
| 0.02% | 0.04% | #45 | $1,601.4万 | 35.9万股 | $2,462.8万 | 47.7万股 | -11.9万股-24.82% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #117 | $1,490.1万 | 33.4万股 | $1,016.3万 | 19.7万股 | +13.7万股+69.53% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #98 | $1,370.7万 | 30.7万股 | $348.9万 | 6.8万股 | +24.0万股+354.27% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.02% | <0.01% | #47 | $1,214.0万 | 27.2万股 | $4,694 | 91股 | +27.2万股+298,943.96% | 加仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.4% | — | #7 | $1,202.1万 | 26.9万股 | $0 | 0股 | +26.9万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #184 | $1,195.0万 | 26.8万股 | $195.9万 | 3.8万股 | +23.0万股+605.22% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #170 | $1,109.9万 | 24.9万股 | $959.7万 | 18.6万股 | +6.3万股+33.71% | 加仓 |
| Walleye资本Walleye Capital LLC |
| 0.04% | 0.08% | #36 | $1,096.3万 | 24.6万股 | $1,853.7万 | 35.9万股 | -11.4万股-31.62% | 减仓 |
| Rock Springs Capital Management LP |
| 0.53% | 0.4% | #6 | $1,088.5万 | 24.4万股 | $679.8万 | 13.2万股 | +11.2万股+85.13% | 加仓 |
| Capital基金管理CAPITAL FUND MANAGEMENT S.A. |
| 0.04% | 0.03% | #35 | $980.9万 | 22.0万股 | $562.3万 | 10.9万股 | +11.1万股+101.69% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #136 | $937.2万 | 21.0万股 | $945.7万 | 18.3万股 | +2.7万股+14.58% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | <0.01% | #156 | $884.5万 | 19.8万股 | $2,579.7万 | 16.2万股 | +3.6万股+22.42% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #174 | $867.7万 | 19.4万股 | $1,824.8万 | 35.4万股 | -15.9万股-45.02% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #112 | $850.1万 | 19.1万股 | $865.0万 | 16.8万股 | +2.3万股+13.63% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | 0.01% | #103 | $786.0万 | 17.6万股 | $2,647.0万 | 51.3万股 | -33.7万股-65.66% | 减仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.01% | 0.02% | #56 | $754.3万 | 16.9万股 | $891.4万 | 17.3万股 | -3,723股-2.15% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #167 | $748.3万 | 16.8万股 | $935.3万 | 18.1万股 | -1.4万股-7.49% | 减仓 |
| 加拿大养老金计划投资委员会(CPPIB)CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | 0.01% | #80 | $736.5万 | 16.5万股 | $846.4万 | 16.4万股 | +1,000股+0.61% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #145 | $663.0万 | 14.9万股 | $767.3万 | 14.9万股 | -137股-0.09% | 减仓 |
| 加拿大丰业银行BANK OF NOVA SCOTIA |
| 0.01% | 0.01% | #58 | $646.7万 | 14.5万股 | $309.5万 | 6.0万股 | +8.5万股+141.61% | 加仓 |
| Quantinno资本管理Quantinno Capital Management LP |
| 0.01% | <0.01% | #68 | $613.9万 | 13.8万股 | $137.0万 | 2.7万股 | +11.1万股+418.23% | 加仓 |
| Edgestream 合伙人Edgestream Partners, L.P. |
| 0.18% | 0.14% | #15 | $596.7万 | 13.4万股 | $424.3万 | 8.2万股 | +5.1万股+62.60% | 加仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| <0.01% | <0.01% | #93 | $571.8万 | 12.8万股 | $654.0万 | 12.7万股 | +1,387股+1.09% | 加仓 |
| 阿尔伯塔投资管理(AIMCo)Alberta Investment Management Corp |
| 0.03% | — | #39 | $548.3万 | 12.3万股 | $0 | 0股 | +12.3万股 | 新买入 |
| Rheos Capital Works Inc. |
| 0.3% | 0.4% | #9 | $523.7万 | 11.7万股 | $605.5万 | 11.7万股 | 00.00% | 持仓不变 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #152 | $517.1万 | 11.6万股 | $1,210.2万 | 23.5万股 | -11.9万股-50.61% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #196 | $492.0万 | 11.0万股 | $536.3万 | 10.4万股 | +6,312股+6.07% | 加仓 |
