| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #145 | $2.45亿 | 295.9万股 | $2.11亿 | 274.7万股 | +21.1万股+7.69% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 2.48% | 2.55% | #4 | $7,183.3万 | 86.8万股 | $6,307.7万 | 82.0万股 | +4.8万股+5.79% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #195 | $6,938.8万 | 83.8万股 | $6,329.4万 | 82.3万股 | +1.5万股+1.84% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #171 | $6,885.5万 | 83.2万股 | $5,933.5万 | 77.2万股 | +6.0万股+7.78% | 加仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 2.66% | 2.76% | #3 | $5,856.7万 | 70.8万股 | $5,440.7万 | 70.8万股 | 00.00% | 持仓不变 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #102 | $5,161.4万 | 62.3万股 | $4,084.3万 | 53.1万股 | +9.2万股+17.37% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.01% | #71 | $4,755.5万 | 57.4万股 | $1,473.2万 | 19.2万股 | +38.3万股+199.87% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | 0.02% | #74 | $4,652.4万 | 56.2万股 | $4,339.9万 | 56.4万股 | -2,344股-0.42% | 减仓 |
| Global Alpha Capital Management Ltd. |
| 2.77% | 1.67% | #2 | $4,619.1万 | 55.8万股 | $2,777.9万 | 36.1万股 | +19.7万股+54.47% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #165 | $4,441.2万 | 53.6万股 | $3,762.6万 | 48.9万股 | +4.7万股+9.65% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #88 | $4,198.7万 | 50.7万股 | $4,552.6万 | 59.2万股 | -8.5万股-14.33% | 减仓 |
| 纽文Nuveen, LLC |
| 0.01% | 0.01% | #110 | $3,435.6万 | 41.5万股 | $3,094.1万 | 40.2万股 | +1.3万股+3.15% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #192 | $3,371.5万 | 40.7万股 | $2,891.2万 | 37.6万股 | +3.1万股+8.33% | 加仓 |
| Ranger Investment Management, L.P. |
| 1.8% | 2% | #6 | $2,840.6万 | 34.3万股 | $2,769.0万 | 36.0万股 | -1.7万股-4.70% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| 0.01% | 0.01% | #112 | $2,677.5万 | 32.3万股 | $2,458.3万 | 32.0万股 | +3,768股+1.18% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #173 | $2,559.8万 | 30.9万股 | $2,494.2万 | 32.4万股 | -1.5万股-4.66% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | 0.01% | #150 | $2,463.0万 | 29.8万股 | $3,827.3万 | 49.8万股 | -20.0万股-40.22% | 减仓 |
| 肯尼迪资本管理KENNEDY CAPITAL MANAGEMENT LLC |
| 0.43% | 0.48% | #20 | $2,449.8万 | 29.6万股 | $2,260.8万 | 29.4万股 | +1,942股+0.66% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #131 | $2,378.9万 | 28.7万股 | $2,078.3万 | 27.0万股 | +1.7万股+6.33% | 加仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.04% | 0.04% | #59 | $2,377.5万 | 28.7万股 | $2,211.4万 | 28.8万股 | -357股-0.12% | 减仓 |
| Ikarian Capital, LLC |
| 2.39% | 1.85% | #5 | $2,252.3万 | 27.2万股 | $2,284.6万 | 29.7万股 | -2.5万股-8.42% | 减仓 |
| 安本标准投资Aberdeen Group plc |
| 0.03% | 0.03% | #62 | $2,249.6万 | 27.2万股 | $1,585.1万 | 20.6万股 | +6.6万股+31.84% | 加仓 |
| 奥伯维斯资产管理OBERWEIS ASSET MANAGEMENT INC/ |
| 0.45% | 0.5% | #19 | $2,196.2万 | 26.5万股 | $1,702.5万 | 22.1万股 | +4.4万股+19.84% | 加仓 |
| 威廉·布莱尔投资管理WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.06% | 0.08% | #46 | $2,137.2万 | 25.8万股 | $2,516.8万 | 32.7万股 | -6.9万股-21.11% | 减仓 |
| Rubric资本管理Rubric Capital Management LP |
| 0.2% | — | #31 | $2,136.8万 | 25.8万股 | $0 | 0股 | +25.8万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #157 | $2,090.8万 | 25.3万股 | $1,801.7万 | 23.4万股 | +1.8万股+7.80% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.09% | 0.24% | #42 | $1,986.7万 | 24.0万股 | $4,121.0万 | 53.6万股 | -29.6万股-55.21% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #202 | $1,967.8万 | 23.3万股 | $1,622.8万 | 22.0万股 | +1.3万股+5.81% | 加仓 |
| 野村控股NOMURA HOLDINGS INC |
| 0.02% | 0.05% | #70 | $1,936.7万 | 23.4万股 | $1,824.3万 | 23.7万股 | -3,270股-1.38% | 减仓 |
| Jones Hill Capital LP |
| 4.11% | 5.25% | #1 | $1,935.5万 | 23.4万股 | $2,450.0万 | 31.9万股 | -8.5万股-26.61% | 减仓 |
| 蒙特利尔银行BANK OF MONTREAL /CAN/ |
| 0.01% | 0.01% | #119 | $1,860.1万 | 22.5万股 | $1,769.3万 | 23.0万股 | -5,365股-2.33% | 减仓 |
| 得克萨斯州教师退休系统TEACHER RETIREMENT SYSTEM OF TEXAS |
| 0.05% | 0.07% | #52 | $1,821.4万 | 22.0万股 | $1,693.5万 | 22.0万股 | -194股-0.09% | 减仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #160 | $1,756.5万 | 21.2万股 | $1,645.1万 | 21.4万股 | -1,727股-0.81% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #208 | $1,748.1万 | 21.1万股 | $2,125.4万 | 23.2万股 | -2.1万股-8.99% | 减仓 |
| 瑞穗证券(美洲)MIZUHO MARKETS AMERICAS LLC |
| 0.24% | 0.44% | #26 | $1,735.4万 | 21.0万股 | $1,620.8万 | 21.1万股 | -1,124股-0.53% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #174 | $1,731.5万 | 20.9万股 | $1,421.5万 | 18.5万股 | +2.4万股+13.15% | 加仓 |
| Penn Capital Management Company, LLC |
| 1.09% | 1.07% | #12 | $1,718.3万 | 20.7万股 | $1,383.4万 | 18.0万股 | +2.8万股+15.38% | 加仓 |
| Parkman Healthcare Partners LLC |
| 1.72% | 2.23% | #7 | $1,679.7万 | 20.3万股 | $2,157.6万 | 28.1万股 | -7.8万股-27.68% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.01% | 0.02% | #86 | $1,597.2万 | 19.3万股 | $1,615.9万 | 21.0万股 | -1.7万股-8.18% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #205 | $1,515.4万 | 18.3万股 | $1,157.6万 | 15.1万股 | +3.3万股+21.61% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #196 | $1,508.5万 | 18.2万股 | $1,689.9万 | 22.0万股 | -3.8万股-17.07% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.01% | 0.01% | #114 | $1,446.4万 | 17.5万股 | $1,641.3万 | 21.3万股 | -3.9万股-18.13% | 减仓 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.02% | 0.02% | #83 | $1,347.6万 | 16.3万股 | $1,253.4万 | 16.3万股 | -194股-0.12% | 减仓 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| 0.02% | 0.01% | #84 | $1,283.0万 | 15.5万股 | $954.3万 | 12.4万股 | +3.1万股+24.90% | 加仓 |
| 罗素投资集团Russell Investments Group, Ltd. |
| 0.01% | 0.01% | #103 | $1,147.2万 | 13.9万股 | $1,068.5万 | 13.9万股 | -353股-0.25% | 减仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #143 | $1,129.2万 | 13.6万股 | $1,109.5万 | 14.4万股 | -7,870股-5.45% | 减仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.01% | #125 | $1,110.5万 | 13.4万股 | $993.1万 | 12.9万股 | +5,003股+3.87% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #163 | $1,105.8万 | 13.4万股 | $978.1万 | 12.7万股 | +6,398股+5.03% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #153 | $1,086.7万 | 13.1万股 | $616.6万 | 8.1万股 | +5.1万股+62.83% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.06% | 0.07% | #48 | $1,008.7万 | 12.2万股 | $934.0万 | 12.1万股 | +393股+0.32% | 加仓 |
