| Bain Capital Life Sciences Investors, LLC |
| 0.38% | 0.5% | #1 | $636.1万 | 66.4万股 | $558.4万 | 66.4万股 | 00.00% | 持仓不变 |
| GILEAD SCIENCES, INC. |
| 0.38% | 0.26% | #2 | $623.1万 | 65.0万股 | $547.0万 | 65.0万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.11% | — | #6 | $567.4万 | 59.2万股 | $0 | 0股 | +59.2万股 | 新买入 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.09% | 0.09% | #7 | $404.8万 | 42.3万股 | $355.3万 | 42.3万股 | 00.00% | 持仓不变 |
| Stonepine Capital Management, LLC |
| 0.33% | 0.22% | #3 | $216.5万 | 22.6万股 | $54.0万 | 6.4万股 | +16.2万股+252.22% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #17 | $171.0万 | 17.9万股 | $104.0万 | 12.4万股 | +5.5万股+44.36% | 加仓 |
| Sio Capital Management, LLC |
| 0.24% | 0.18% | #4 | $146.1万 | 15.2万股 | $128.2万 | 15.2万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | — | #12 | $106.9万 | 11.2万股 | $0 | 0股 | +11.2万股 | 新买入 |
| Merck & Co., Inc. |
| 0.19% | 0.26% | #5 | $101.5万 | 10.6万股 | $89.1万 | 10.6万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #13 | $61.5万 | 6.4万股 | $41.7万 | 5.0万股 | +1.5万股+29.43% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #19 | $54.6万 | 5.7万股 | $81.1万 | 96.2万股 | -90.5万股-94.08% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #21 | $37.4万 | 3.9万股 | $31.3万 | 3.7万股 | +1,858股+5.00% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #20 | $24.9万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #16 | $21.6万 | 2.3万股 | $23.9万 | 2.8万股 | -5,881股-20.65% | 减仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #11 | $16.8万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #14 | $13.9万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| Velan Capital Investment Management LP |
| 0.08% | 0.08% | #8 | $13.7万 | 1.4万股 | $12.0万 | 1.4万股 | 00.00% | 持仓不变 |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | 0.01% | #9 | $13.0万 | 1.4万股 | $14.3万 | 1.7万股 | -3,356股-19.80% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #22 | $12.8万 | 1.3万股 | $11.2万 | 1.3万股 | 00.00% | 持仓不变 |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.01% | — | #10 | $11.1万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | — | #23 | $8.4万 | 8,757股 | $0 | 0股 | +8,757股 | 新买入 |
| Steward合伙人投资顾问Steward Partners Investment Advisory, LLC |
| <0.01% | — | #18 | $6,840 | 714股 | $0 | 0股 | +714股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | — | #24 | $1,102 | 115股 | $0 | 0股 | +115股 | 新买入 |
| Key FInancial Inc |
| <0.01% | <0.01% | #15 | $565 | 59股 | $496 | 59股 | 00.00% | 持仓不变 |
| 琼斯金融JONES FINANCIAL COMPANIES LLLP |
| <0.01% | — | #25 | $262 | 29股 | $0 | 0股 | +29股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #26 | $134 | 14股 | $3.4万 | 4,038股 | -4,024股-99.65% | 减仓 |
