| 富达投资FMR LLC |
| 0.04% | 0.02% | #82 | $8.62亿 | 905.8万股 | $3.65亿 | 743.1万股 | +162.6万股+21.88% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | <0.01% | #126 | $4.75亿 | 499.0万股 | $1.73亿 | 352.7万股 | +146.3万股+41.48% | 加仓 |
| Venrock Adviser, LLC |
| 11.97% | 7.6% | #3 | $3.95亿 | 414.8万股 | $2.03亿 | 414.8万股 | 00.00% | 持仓不变 |
| Fairmount Funds Management LLC |
| 23.31% | 13.13% | #2 | $3.53亿 | 370.5万股 | $1.82亿 | 370.5万股 | 00.00% | 持仓不变 |
| 资本世界投资者Capital World Investors |
| 0.04% | — | #81 | $3.24亿 | 340.2万股 | $0 | 0股 | +340.2万股 | 新买入 |
| RTW投资RTW INVESTMENTS, LP |
| 2.55% | 1% | #16 | $2.99亿 | 313.9万股 | $1.01亿 | 205.8万股 | +108.1万股+52.52% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #124 | $2.54亿 | 267.3万股 | $7,914.0万 | 161.3万股 | +106.0万股+65.67% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #135 | $2.25亿 | 236.1万股 | $9,121.5万 | 186.0万股 | +50.1万股+26.96% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 3.82% | 2.33% | #5 | $2.04亿 | 214.5万股 | $1.14亿 | 232.0万股 | -17.6万股-7.58% | 减仓 |
| 深轨资本Deep Track Capital, LP |
| 2.67% | 1.63% | #14 | $1.83亿 | 192.6万股 | $9,977.8万 | 203.4万股 | -10.8万股-5.32% | 减仓 |
| Bellevue 集团Bellevue Group AG |
| 3.32% | 0.59% | #8 | $1.58亿 | 165.7万股 | $2,486.9万 | 50.7万股 | +115.0万股+226.86% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.03% | 0.01% | #85 | $1.54亿 | 162.1万股 | $4,924.9万 | 100.4万股 | +61.7万股+61.49% | 加仓 |
| Remedium Capital Partners, LLC |
| 32.99% | 27.31% | #1 | $1.49亿 | 156.6万股 | $7,679.6万 | 156.6万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.29% | — | #24 | $1.48亿 | 155.5万股 | $0 | 0股 | +155.5万股 | 新买入 |
| 维京全球投资VIKING GLOBAL INVESTORS LP |
| 0.41% | 0.37% | #42 | $1.43亿 | 150.3万股 | $1.31亿 | 266.7万股 | -116.3万股-43.62% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #125 | $1.36亿 | 143.0万股 | $4,684.8万 | 95.5万股 | +47.5万股+49.75% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.05% | — | #75 | $1.31亿 | 137.6万股 | $0 | 0股 | +137.6万股 | 新买入 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 1.92% | 1.34% | #18 | $1.28亿 | 134.5万股 | $6,844.9万 | 139.6万股 | -5.0万股-3.61% | 减仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.28% | 0.18% | #46 | $1.17亿 | 122.9万股 | $5,138.9万 | 104.8万股 | +18.1万股+17.27% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #104 | $1.10亿 | 115.3万股 | $4,995.9万 | 101.9万股 | +13.4万股+13.16% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.07% | — | #67 | $1.05亿 | 110.4万股 | $0 | 0股 | +110.4万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.05% | <0.01% | #77 | $1.03亿 | 107.9万股 | $53.6万 | 1.1万股 | +106.8万股+9,773.86% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #121 | $7,981.0万 | 83.9万股 | $3,568.2万 | 72.7万股 | +11.1万股+15.28% | 加仓 |
| Avidity Partners Management LP |
| 11.59% | 7.55% | #4 | $7,237.0万 | 76.0万股 | $3,729.9万 | 76.0万股 | 00.00% | 持仓不变 |
| 峰会合伙人公共资产SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
| 1.1% | — | #26 | $6,265.1万 | 65.8万股 | $0 | 0股 | +65.8万股 | 新买入 |
| 安本标准投资Aberdeen Group plc |
| 0.09% | 0.01% | #64 | $6,157.0万 | 64.7万股 | $371.2万 | 7.6万股 | +57.1万股+754.84% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | <0.01% | #122 | $6,084.8万 | 63.9万股 | $1,041.2万 | 21.2万股 | +42.7万股+201.20% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #149 | $6,073.6万 | 65.5万股 | $103.0万 | 2.3万股 | +63.2万股+2,795.79% | 加仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.2% | 0.06% | #48 | $6,009.3万 | 63.1万股 | $1,535.9万 | 31.3万股 | +31.8万股+101.65% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.06% | — | #72 | $5,891.5万 | 61.9万股 | $0 | 0股 | +61.9万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 2.54% | 1.27% | #17 | $5,615.0万 | 59.0万股 | $2,450.9万 | 50.0万股 | +9.0万股+18.08% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #158 | $5,542.8万 | 58.2万股 | $1,721.1万 | 35.1万股 | +23.2万股+65.98% | 加仓 |
| Cormorant Asset Management, LP |
| 2.58% | 1.31% | #15 | $5,075.8万 | 53.3万股 | $2,616.0万 | 53.3万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #132 | $4,124.7万 | 43.3万股 | $1,579.2万 | 32.2万股 | +11.1万股+34.62% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #136 | $4,081.8万 | 42.9万股 | $1,466.8万 | 29.9万股 | +13.0万股+43.42% | 加仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | <0.01% | #84 | $3,817.7万 | 40.1万股 | $326.7万 | 6.7万股 | +33.5万股+502.33% | 加仓 |
| LORD, ABBETT & CO. LLC |
| 0.11% | — | #60 | $3,712.2万 | 39.0万股 | $0 | 0股 | +39.0万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #123 | $3,479.7万 | 36.6万股 | $1,260.9万 | 25.7万股 | +10.9万股+42.23% | 加仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | — | #109 | $3,465.2万 | 36.4万股 | $0 | 0股 | +36.4万股 | 新买入 |
| Synergy Asset Management, LLC |
| 3.2% | 2.48% | #10 | $3,390.9万 | 35.6万股 | $2,335.7万 | 47.6万股 | -12.0万股-25.18% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.05% | 0.01% | #78 | $3,378.6万 | 35.5万股 | $932.1万 | 19.0万股 | +16.5万股+86.81% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #161 | $3,357.8万 | 35.3万股 | $490.9万 | 10.0万股 | +25.3万股+252.50% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 3.49% | 0.76% | #6 | $3,357.6万 | 35.3万股 | $740.2万 | 15.1万股 | +20.2万股+133.79% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.15% | 0.06% | #55 | $3,353.6万 | 35.3万股 | $1,214.0万 | 40.1万股 | -4.8万股-11.93% | 减仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.07% | 0.02% | #69 | $2,911.7万 | 30.6万股 | $909.9万 | 18.6万股 | +12.0万股+64.92% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.02% | 0.01% | #100 | $2,848.0万 | 29.9万股 | $866.6万 | 17.7万股 | +12.3万股+69.38% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.08% | 0.11% | #65 | $2,714.7万 | 28.5万股 | $2,819.8万 | 57.5万股 | -29.0万股-50.38% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #164 | $2,662.7万 | 28.0万股 | $344.3万 | 7.0万股 | +21.0万股+298.65% | 加仓 |
| BRAIDWELL LP |
| 0.98% | — | #28 | $2,647.3万 | 27.8万股 | $0 | 0股 | +27.8万股 | 新买入 |
| Siren, L.L.C. |
| 0.48% | — | #36 | $2,379.3万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
