| 富达投资FMR LLC |
| 0.02% | 0.02% | #67 | $5.26亿 | 1,410.9万股 | $4.39亿 | 1,317.2万股 | +93.7万股+7.12% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #112 | $3.31亿 | 889.3万股 | $2.81亿 | 844.2万股 | +45.1万股+5.34% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.13% | — | #37 | $3.20亿 | 858.0万股 | $0 | 0股 | +858.0万股 | 新买入 |
| 资本研究全球投资者Capital Research Global Investors |
| 0.03% | 0.03% | #59 | $1.99亿 | 534.5万股 | $1.72亿 | 516.4万股 | +18.1万股+3.51% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.94% | 0.76% | #15 | $1.87亿 | 501.0万股 | $1.31亿 | 394.7万股 | +106.4万股+26.95% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #111 | $1.70亿 | 454.9万股 | $1.26亿 | 378.1万股 | +76.8万股+20.30% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #131 | $1.54亿 | 413.3万股 | $1.24亿 | 373.2万股 | +40.0万股+10.72% | 加仓 |
| Logos Global Management LP |
| 4.81% | 5.74% | #2 | $1.12亿 | 300.0万股 | $1.15亿 | 345.0万股 | -45.0万股-13.04% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.14% | 0.15% | #36 | $1.01亿 | 271.5万股 | $9,407.9万 | 282.4万股 | -10.8万股-3.83% | 减仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.06% | 0.6% | #11 | $1.01亿 | 271.5万股 | $5,098.0万 | 153.0万股 | +118.4万股+77.42% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | 0.01% | #114 | $9,041.9万 | 242.6万股 | $8,333.7万 | 250.1万股 | -7.5万股-3.00% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | <0.01% | #91 | $8,227.2万 | 220.7万股 | $4,384.5万 | 131.6万股 | +89.2万股+67.76% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #126 | $7,198.7万 | 193.1万股 | $4,300.1万 | 158.0万股 | +35.1万股+22.22% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #83 | $6,191.1万 | 166.1万股 | $4,441.8万 | 133.3万股 | +32.8万股+24.58% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.02% | <0.01% | #72 | $5,422.9万 | 162.8万股 | $348.4万 | 10.1万股 | +152.7万股+1,514.83% | 加仓 |
| Fiera资本Fiera Capital Corp |
| 0.2% | 0.29% | #27 | $5,388.8万 | 144.6万股 | $8,420.2万 | 252.7万股 | -108.1万股-42.78% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.08% | 0.16% | #44 | $5,335.7万 | 143.2万股 | $9,953.0万 | 298.7万股 | -155.5万股-52.07% | 减仓 |
| GSK plc |
| 8.25% | 7.41% | #1 | $4,969.3万 | 133.3万股 | $4,442.7万 | 133.3万股 | 00.00% | 持仓不变 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.05% | — | #49 | $4,732.9万 | 127.0万股 | $0 | 0股 | +127.0万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #124 | $4,590.2万 | 123.2万股 | $6,376.2万 | 191.4万股 | -68.2万股-35.64% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.18% | 0.18% | #29 | $4,067.1万 | 109.2万股 | $3,565.5万 | 103.1万股 | +6.1万股+5.91% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #147 | $3,824.4万 | 102.6万股 | $3,139.0万 | 94.2万股 | +8.4万股+8.92% | 加仓 |
| Sofinnova Investments, Inc. |
| 1.78% | 1.43% | #7 | $3,447.9万 | 92.5万股 | $3,771.1万 | 113.2万股 | -20.7万股-18.26% | 减仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | — | #77 | $3,323.0万 | 89.2万股 | $0 | 0股 | +89.2万股 | 新买入 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.01% | 0.01% | #85 | $3,172.8万 | 85.1万股 | $2,941.2万 | 88.3万股 | -3.1万股-3.56% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #173 | $3,062.1万 | 82.2万股 | $2,484.3万 | 74.6万股 | +7.6万股+10.20% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #129 | $2,996.9万 | 80.4万股 | $2,446.1万 | 73.4万股 | +7.0万股+9.53% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #127 | $2,813.5万 | 75.5万股 | $2,384.1万 | 71.6万股 | +3.9万股+5.50% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.03% | 0.03% | #62 | $2,656.1万 | 71.3万股 | $2,385.4万 | 71.6万股 | -3,232股-0.45% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #138 | $2,447.6万 | 65.7万股 | $2,540.8万 | 76.3万股 | -10.6万股-13.88% | 减仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #103 | $2,386.2万 | 64.0万股 | $1,493.6万 | 44.8万股 | +19.2万股+42.83% | 加仓 |
| Redmile Group, LLC |
| 1.6% | 1.15% | #8 | $2,386.0万 | 64.0万股 | $1,736.4万 | 52.1万股 | +11.9万股+22.85% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #110 | $2,314.6万 | 62.1万股 | $1,871.1万 | 56.2万股 | +5.9万股+10.59% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.02% | 0.02% | #71 | $2,208.1万 | 59.2万股 | $1,946.0万 | 58.4万股 | +8,440股+1.45% | 加仓 |
| 安本标准投资Aberdeen Group plc |
| 0.03% | 0.03% | #57 | $2,090.6万 | 56.1万股 | $1,818.0万 | 54.6万股 | +1.5万股+2.80% | 加仓 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| 0.02% | 0.02% | #65 | $1,870.9万 | 50.2万股 | $1,717.5万 | 51.5万股 | -1.3万股-2.61% | 减仓 |
| DAFNA Capital Management LLC |
| 3.53% | 3.61% | #3 | $1,853.2万 | 49.7万股 | $1,588.5万 | 47.7万股 | +2.1万股+4.30% | 加仓 |
| Sio Capital Management, LLC |
| 2.96% | — | #4 | $1,790.4万 | 48.0万股 | $0 | 0股 | +48.0万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #172 | $1,775.7万 | 47.6万股 | $839.7万 | 25.2万股 | +22.4万股+89.06% | 加仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 0.76% | 0.76% | #16 | $1,677.2万 | 45.0万股 | $1,499.4万 | 45.0万股 | 00.00% | 持仓不变 |
| Affinity Asset Advisors, LLC |
| 0.67% | — | #18 | $1,490.8万 | 40.0万股 | $0 | 0股 | +40.0万股 | 新买入 |
| Walleye资本Walleye Capital LLC |
| 0.05% | — | #48 | $1,439.3万 | 38.6万股 | $0 | 0股 | +38.6万股 | 新买入 |
| RTW投资RTW INVESTMENTS, LP |
| 0.12% | — | #39 | $1,380.4万 | 37.0万股 | $0 | 0股 | +37.0万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #168 | $1,366.8万 | 36.7万股 | $2,576.0万 | 77.3万股 | -40.6万股-52.56% | 减仓 |
| Rhenman & Partners Asset Management AB |
| 1.21% | 1.05% | #10 | $1,281.3万 | 34.4万股 | $851.3万 | 25.6万股 | +8.8万股+34.56% | 加仓 |
| BIT Capital GmbH |
| 0.34% | — | #21 | $1,160.3万 | 31.1万股 | $0 | 0股 | +31.1万股 | 新买入 |
| GENERAL AMERICAN INVESTORS CO INC |
| 0.68% | 0.61% | #17 | $1,148.8万 | 30.8万股 | $933.8万 | 28.0万股 | +2.8万股+9.98% | 加仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | <0.01% | #97 | $1,143.2万 | 30.7万股 | $155.6万 | 4.7万股 | +26.0万股+556.99% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #160 | $1,110.1万 | 29.8万股 | $810.8万 | 24.3万股 | +5.5万股+22.41% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.01% | 0.01% | #81 | $1,109.0万 | 29.8万股 | $694.2万 | 20.8万股 | +8.9万股+42.82% | 加仓 |
