| 富达投资FMR LLC |
| 0.03% | 0.03% | #80 | $7.99亿 | 820.0万股 | $6.52亿 | 776.8万股 | +43.2万股+5.56% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | <0.01% | #137 | $4.02亿 | 412.4万股 | $2.67亿 | 317.6万股 | +94.8万股+29.86% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.25% | 0.07% | #45 | $3.79亿 | 388.8万股 | $1.08亿 | 129.2万股 | +259.6万股+200.92% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.05% | 0.04% | #73 | $3.15亿 | 323.0万股 | $2.18亿 | 259.6万股 | +63.4万股+24.43% | 加仓 |
| Fairmount Funds Management LLC |
| 16.35% | 15.38% | #2 | $2.47亿 | 253.7万股 | $2.13亿 | 253.7万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #88 | $2.45亿 | 251.5万股 | $9,625.3万 | 114.7万股 | +136.8万股+119.27% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #131 | $2.30亿 | 235.7万股 | $1.17亿 | 139.9万股 | +95.9万股+68.52% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #152 | $2.11亿 | 216.0万股 | $1.70亿 | 203.1万股 | +12.8万股+6.32% | 加仓 |
| Avidity Partners Management LP |
| 32.85% | 35.76% | #1 | $2.05亿 | 210.4万股 | $1.77亿 | 210.4万股 | 00.00% | 持仓不变 |
| Octagon Capital Advisors LP |
| 16.14% | 18.08% | #3 | $1.80亿 | 184.2万股 | $1.63亿 | 194.7万股 | -10.5万股-5.39% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 3.93% | 4.03% | #6 | $1.63亿 | 167.7万股 | $1.41亿 | 167.7万股 | 00.00% | 持仓不变 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.42% | 0.43% | #37 | $1.27亿 | 130.2万股 | $9,750.9万 | 116.2万股 | +14.1万股+12.10% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #133 | $1.23亿 | 125.9万股 | $7,690.5万 | 91.6万股 | +34.2万股+37.36% | 加仓 |
| Venrock Adviser, LLC |
| 3.49% | 3.7% | #8 | $1.15亿 | 118.0万股 | $9,902.6万 | 118.0万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #101 | $1.11亿 | 114.0万股 | $6,556.5万 | 78.1万股 | +35.9万股+45.95% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.14% | 1.01% | #25 | $1.10亿 | 112.5万股 | $8,558.3万 | 102.0万股 | +10.6万股+10.35% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | 0.02% | #105 | $1.00亿 | 102.6万股 | $1.38亿 | 164.9万股 | -62.3万股-37.79% | 减仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.06% | 0.03% | #71 | $9,960.1万 | 102.2万股 | $4,071.3万 | 48.5万股 | +53.7万股+110.61% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.23% | 0.32% | #47 | $9,930.5万 | 101.9万股 | $9,029.9万 | 107.6万股 | -5.7万股-5.32% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.02% | 0.02% | #94 | $9,445.6万 | 96.9万股 | $8,125.0万 | 96.8万股 | +801股+0.08% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.42% | 0.41% | #38 | $8,306.9万 | 85.2万股 | $7,151.4万 | 85.2万股 | 00.00% | 持仓不变 |
| Logos Global Management LP |
| 3.36% | 1.68% | #9 | $7,798.4万 | 80.0万股 | $3,356.8万 | 40.0万股 | +40.0万股+100.00% | 加仓 |
| Cormorant Asset Management, LP |
| 3.71% | 4% | #7 | $7,311.0万 | 75.0万股 | $7,972.4万 | 95.0万股 | -20.0万股-21.05% | 减仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.01% | #90 | $7,000.2万 | 83.4万股 | $3,816.3万 | 92.6万股 | -9.2万股-9.93% | 减仓 |
| BRAIDWELL LP |
| 2.14% | 2.52% | #15 | $5,795.8万 | 59.5万股 | $7,547.5万 | 89.9万股 | -30.5万股-33.89% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #171 | $5,557.5万 | 57.0万股 | $2,932.0万 | 34.9万股 | +22.1万股+63.18% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.01% | 0.01% | #110 | $5,186.0万 | 53.2万股 | $3,008.3万 | 35.8万股 | +17.4万股+48.41% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.15% | 0.14% | #58 | $4,879.3万 | 50.1万股 | $3,637.6万 | 43.3万股 | +6.7万股+15.48% | 加仓 |
| 巴克莱BARCLAYS PLC |
| 0.01% | 0.01% | #122 | $4,208.7万 | 43.2万股 | $3,185.7万 | 38.0万股 | +5.2万股+13.74% | 加仓 |
| LORD, ABBETT & CO. LLC |
| 0.12% | 0.08% | #60 | $4,115.5万 | 42.2万股 | $2,511.0万 | 29.9万股 | +12.3万股+41.10% | 加仓 |
| MPM BioImpact LLC |
| 2.5% | 2.75% | #14 | $4,094.2万 | 42.0万股 | $3,558.1万 | 42.4万股 | -3,980股-0.94% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #149 | $4,014.1万 | 41.2万股 | $2,549.1万 | 30.4万股 | +10.8万股+35.57% | 加仓 |
| Affinity Asset Advisors, LLC |
| 1.76% | 1.73% | #18 | $3,899.2万 | 40.0万股 | $3,356.8万 | 40.0万股 | 00.00% | 持仓不变 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 3.95% | 5.61% | #5 | $3,801.7万 | 39.0万股 | $5,494.6万 | 65.5万股 | -26.5万股-40.43% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #163 | $3,725.3万 | 38.2万股 | $4,598.9万 | 54.8万股 | -16.6万股-30.26% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #147 | $3,567.4万 | 36.6万股 | $2,563.3万 | 30.5万股 | +6.1万股+19.82% | 加仓 |
| Bain Capital Life Sciences Investors, LLC |
| 2.1% | 2.74% | #17 | $3,533.4万 | 36.2万股 | $3,041.8万 | 36.2万股 | 00.00% | 持仓不变 |
| Spruce Street Capital LP |
| 6.79% | 7.53% | #4 | $3,458.7万 | 35.5万股 | $3,132.5万 | 37.3万股 | -1.8万股-4.94% | 减仓 |
| Vivo Capital, LLC |
| 3.15% | 2.47% | #10 | $3,450.8万 | 35.4万股 | $2,970.8万 | 35.4万股 | 00.00% | 持仓不变 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | 0.01% | #139 | $3,133.4万 | 32.2万股 | $2,729.6万 | 32.5万股 | -3,937股-1.21% | 减仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.1% | — | #61 | $3,069.8万 | 31.5万股 | $0 | 0股 | +31.5万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #134 | $2,948.6万 | 30.2万股 | $2,095.3万 | 25.0万股 | +5.3万股+21.15% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.17% | 0.2% | #56 | $2,878.3万 | 29.5万股 | $2,662.9万 | 31.7万股 | -2.2万股-6.95% | 减仓 |
| First Turn Management, LLC |
| 2.98% | 2.07% | #11 | $2,785.7万 | 28.6万股 | $1,854.0万 | 22.1万股 | +6.5万股+29.35% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.03% | — | #82 | $2,735.8万 | 28.1万股 | $0 | 0股 | +28.1万股 | 新买入 |
| TANG CAPITAL MANAGEMENT LLC |
| 1.17% | 1.13% | #24 | $2,580.2万 | 26.5万股 | $2,221.3万 | 26.5万股 | 00.00% | 持仓不变 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.04% | 0.05% | #78 | $2,517.6万 | 25.8万股 | $3,206.8万 | 38.2万股 | -12.4万股-32.41% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #186 | $2,503.6万 | 25.7万股 | $1,584.2万 | 18.9万股 | +6.8万股+36.05% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #156 | $2,499.3万 | 25.6万股 | $1,581.2万 | 18.8万股 | +6.8万股+36.08% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.21% | 0.21% | #50 | $2,418.1万 | 24.8万股 | $2,081.7万 | 24.8万股 | 00.00% | 持仓不变 |
