| 富达投资FMR LLC |
| 0.04% | 0.02% | #46 | $8.40亿 | 2,909.4万股 | $4.65亿 | 2,569.7万股 | +339.7万股+13.22% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 2.45% | 1.64% | #12 | $2.35亿 | 813.8万股 | $1.39亿 | 768.8万股 | +45.0万股+5.85% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 3.73% | 3.5% | #8 | $2.04亿 | 707.0万股 | $1.37亿 | 758.1万股 | -51.1万股-6.74% | 减仓 |
| 高瓴资本Hillhouse Capital Advisors, Ltd. |
| 20.77% | 6.47% | #1 | $1.73亿 | 598.5万股 | $1.08亿 | 598.5万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #108 | $1.37亿 | 472.7万股 | $8,474.3万 | 468.5万股 | +4.2万股+0.90% | 加仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.42% | 0.44% | #18 | $1.28亿 | 443.0万股 | $1.04亿 | 576.3万股 | -133.3万股-23.14% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #68 | $1.06亿 | 366.2万股 | $2,648.6万 | 146.4万股 | +219.8万股+150.14% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.1% | 0.09% | #30 | $8,883.8万 | 307.6万股 | $7,029.8万 | 388.6万股 | -81.0万股-20.84% | 减仓 |
| Kynam Capital Management, LP |
| 4.79% | 1.76% | #5 | $8,667.5万 | 300.1万股 | $2,851.5万 | 157.6万股 | +142.5万股+90.40% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.07% | — | #37 | $5,530.7万 | 191.5万股 | $0 | 0股 | +191.5万股 | 新买入 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.07% | 0.07% | #34 | $4,503.7万 | 155.9万股 | $4,078.4万 | 225.4万股 | -69.5万股-30.83% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #127 | $4,329.2万 | 149.9万股 | $2,710.6万 | 149.8万股 | +332股+0.02% | 加仓 |
| 资本国际投资者Capital International Investors |
| 0.01% | <0.01% | #69 | $4,102.8万 | 142.1万股 | $1,172.0万 | 64.8万股 | +77.3万股+119.29% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #105 | $4,027.4万 | 139.5万股 | $1,405.7万 | 43.1万股 | +96.3万股+223.50% | 加仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 1.2% | — | #13 | $3,480.0万 | 120.5万股 | $0 | 0股 | +120.5万股 | 新买入 |
| Davern Capital Partners, LP |
| 5.87% | 6.52% | #4 | $3,441.1万 | 119.2万股 | $2,378.4万 | 131.5万股 | -12.3万股-9.37% | 减仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.19% | — | #25 | $3,346.6万 | 115.9万股 | $0 | 0股 | +115.9万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.01% | #44 | $2,888.6万 | 100.0万股 | $943.9万 | 52.2万股 | +47.8万股+91.68% | 加仓 |
| 吉萨洛资本管理Ghisallo Capital Management LLC |
| 0.17% | — | #27 | $2,888.0万 | 100.0万股 | $0 | 0股 | +100.0万股 | 新买入 |
| MATTHEWS INTERNATIONAL CAPITAL MANAGEMENT LLC |
| 8.89% | 6.8% | #3 | $2,649.1万 | 91.7万股 | $1,675.0万 | 92.6万股 | -8,654股-0.93% | 减仓 |
| JOHNSON & JOHNSON |
| 2.95% | 2.26% | #11 | $2,352.5万 | 81.5万股 | $1,473.6万 | 81.5万股 | 00.00% | 持仓不变 |
| IvyRock Asset Management (HK) Ltd |
| 13.08% | 8.17% | #2 | $2,313.3万 | 80.1万股 | $1,454.4万 | 80.4万股 | -3,000股-0.37% | 减仓 |
| EcoR1 Capital, LLC |
| 1.12% | — | #14 | $2,310.4万 | 80.0万股 | $0 | 0股 | +80.0万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #130 | $2,252.3万 | 76.6万股 | $498.7万 | 28.8万股 | +47.8万股+166.00% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.02% | 0.01% | #56 | $2,221.6万 | 76.9万股 | $867.4万 | 47.9万股 | +29.0万股+60.43% | 加仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.01% | <0.01% | #67 | $2,194.9万 | 76.0万股 | $736.1万 | 40.7万股 | +35.3万股+86.78% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.06% | 0.01% | #40 | $1,915.0万 | 66.3万股 | $372.4万 | 20.6万股 | +45.7万股+222.09% | 加仓 |
| Triata Capital Ltd |
| 3.09% | 2.07% | #10 | $1,819.2万 | 63.0万股 | $1,139.5万 | 63.0万股 | 00.00% | 持仓不变 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | — | #57 | $1,732.8万 | 60.0万股 | $0 | 0股 | +60.0万股 | 新买入 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | <0.01% | #77 | $1,659.7万 | 57.5万股 | $1,040.0万 | 57.5万股 | -213股-0.04% | 减仓 |
| Elmind Capital, LP |
| 4.14% | — | #6 | $1,647.8万 | 57.1万股 | $0 | 0股 | +57.1万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #144 | $1,615.8万 | 56.3万股 | $987.3万 | 55.0万股 | +1.3万股+2.44% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.07% | 0.03% | #38 | $1,456.8万 | 50.5万股 | $569.2万 | 26.2万股 | +24.3万股+92.86% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #111 | $1,451.1万 | 50.2万股 | $552.1万 | 30.5万股 | +19.7万股+64.63% | 加仓 |
| CenterBook Partners LP |
| 0.64% | 0.2% | #15 | $1,308.0万 | 45.3万股 | $370.1万 | 20.5万股 | +24.8万股+121.36% | 加仓 |
| ArrowMark Colorado Holdings LLC |
| 0.44% | 0.35% | #17 | $1,047.7万 | 36.3万股 | $1,315.4万 | 72.7万股 | -36.4万股-50.11% | 减仓 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| 0.03% | 0.06% | #54 | $981.9万 | 34.0万股 | $1,857.0万 | 102.7万股 | -68.7万股-66.88% | 减仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.02% | <0.01% | #59 | $888.0万 | 30.7万股 | $19.0万 | 1.1万股 | +29.7万股+2,826.65% | 加仓 |
| Empire Life Investments Inc. |
| 0.48% | 0.35% | #16 | $856.5万 | 29.7万股 | $573.3万 | 30.1万股 | -4,372股-1.45% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #140 | $834.5万 | 28.9万股 | $1,227.4万 | 67.8万股 | -39.0万股-57.41% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #142 | $793.8万 | 27.5万股 | $506.9万 | 28.0万股 | -5,370股-1.92% | 减仓 |
| Resolute Capital Asset Partners LLC |
| 3.22% | — | #9 | $753.4万 | 26.1万股 | $0 | 0股 | +26.1万股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #89 | $726.2万 | 25.1万股 | $424.3万 | 23.5万股 | +1.7万股+7.21% | 加仓 |
| Burkehill Global 管理Burkehill Global Management, LP |
| 0.26% | — | #21 | $722.0万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #120 | $721.3万 | 25.0万股 | $136.5万 | 7.5万股 | +17.4万股+231.08% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #158 | $715.9万 | 24.8万股 | $27.7万 | 1.5万股 | +23.3万股+1,520.80% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #157 | $698.0万 | 24.2万股 | $257.4万 | 14.2万股 | +9.9万股+69.85% | 加仓 |
| Tidal投资Tidal Investments LLC |
| 0.01% | 0.01% | #66 | $694.5万 | 24.0万股 | $324.6万 | 17.9万股 | +6.1万股+34.01% | 加仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #94 | $682.1万 | 23.6万股 | $400.6万 | 22.1万股 | +1.5万股+6.65% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | — | #131 | $659.1万 | 22.8万股 | $0 | 0股 | +22.8万股 | 新买入 |
