| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 4.15% | 5.19% | #10 | $8.28亿 | 791.6万股 | $9.04亿 | 791.6万股 | 00.00% | 持仓不变 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 3.19% | 3.82% | #13 | $3.56亿 | 340.0万股 | $3.88亿 | 357.5万股 | -17.5万股-4.90% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 2.95% | 3.45% | #14 | $3.46亿 | 330.5万股 | $3.47亿 | 304.0万股 | +26.5万股+8.73% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 5.02% | 6.97% | #8 | $3.34亿 | 319.7万股 | $3.57亿 | 312.7万股 | +7.0万股+2.24% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | 0.01% | #149 | $3.16亿 | 301.9万股 | $3.09亿 | 271.2万股 | +30.7万股+11.33% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #136 | $2.05亿 | 195.5万股 | $1.73亿 | 151.9万股 | +43.7万股+28.75% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | 0.01% | #157 | $1.96亿 | 187.4万股 | $2.03亿 | 178.3万股 | +9.1万股+5.12% | 加仓 |
| NEA Management Company, LLC |
| 11.27% | 14.83% | #2 | $1.79亿 | 171.1万股 | $2.61亿 | 228.6万股 | -57.5万股-25.16% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 6.14% | 5.94% | #4 | $1.78亿 | 170.4万股 | $1.47亿 | 128.4万股 | +42.0万股+32.70% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #114 | $1.54亿 | 147.1万股 | $8,153.4万 | 71.4万股 | +75.7万股+105.97% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.58% | 2.31% | #17 | $1.52亿 | 145.1万股 | $1.96亿 | 171.4万股 | -26.3万股-15.34% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #126 | $1.40亿 | 133.5万股 | $7,473.5万 | 151.3万股 | -17.8万股-11.79% | 减仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 6.25% | 6.09% | #3 | $1.38亿 | 131.5万股 | $1.20亿 | 105.0万股 | +26.5万股+25.20% | 加仓 |
| 多伦多道明银行TORONTO DOMINION BANK |
| 0.15% | 0.14% | #44 | $1.32亿 | 125.9万股 | $1.01亿 | 88.3万股 | +37.6万股+42.59% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #135 | $1.16亿 | 111.2万股 | $1.02亿 | 89.1万股 | +22.1万股+24.76% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.02% | #112 | $1.07亿 | 102.6万股 | $1.46亿 | 128.0万股 | -25.4万股-19.84% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.01% | #102 | $9,484.8万 | 90.7万股 | $4,896.1万 | 42.9万股 | +47.8万股+111.35% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #121 | $9,106.6万 | 87.0万股 | $8,731.4万 | 76.5万股 | +10.5万股+13.79% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #128 | $8,954.2万 | 85.6万股 | $7,929.3万 | 69.5万股 | +16.1万股+23.20% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.08% | 0.05% | #63 | $6,809.9万 | 65.1万股 | $3,652.8万 | 32.0万股 | +33.1万股+103.40% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 0.48% | — | #28 | $6,574.4万 | 62.8万股 | $0 | 0股 | +62.8万股 | 新买入 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.01% | #95 | $6,059.9万 | 53.1万股 | $4,631.2万 | 46.4万股 | +6.7万股+14.34% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #174 | $5,743.5万 | 54.9万股 | $415.0万 | 3.6万股 | +51.3万股+1,409.85% | 加仓 |
| APIS CAPITAL ADVISORS, LLC |
| 5.48% | 9.07% | #6 | $5,628.6万 | 53.8万股 | $5,878.2万 | 51.5万股 | +2.3万股+4.47% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.13% | 0.1% | #52 | $5,577.8万 | 53.3万股 | $4,222.9万 | 37.0万股 | +16.3万股+44.10% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | <0.01% | #129 | $5,450.1万 | 52.1万股 | $2,512.9万 | 22.0万股 | +30.1万股+136.62% | 加仓 |
| Fuller & Thaler资产管理FULLER & THALER ASSET MANAGEMENT, INC. |
| 0.15% | — | #46 | $5,381.6万 | 51.4万股 | $0 | 0股 | +51.4万股 | 新买入 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 5.45% | 4.17% | #7 | $5,241.4万 | 50.1万股 | $4,085.1万 | 35.8万股 | +14.3万股+39.98% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #87 | $5,171.9万 | 49.4万股 | $2,191.5万 | 19.2万股 | +30.2万股+157.48% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.24% | 0.4% | #40 | $5,148.4万 | 49.2万股 | $6,848.4万 | 60.0万股 | -10.8万股-17.98% | 减仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.08% | 0.08% | #62 | $4,829.2万 | 46.2万股 | $5,217.0万 | 45.7万股 | +4,521股+0.99% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | — | #94 | $4,654.7万 | 44.5万股 | $0 | 0股 | +44.5万股 | 新买入 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.14% | — | #47 | $4,371.2万 | 41.8万股 | $0 | 0股 | +41.8万股 | 新买入 |
| Boxer Capital Management, LLC |
| 3.28% | 3.37% | #12 | $4,357.7万 | 41.7万股 | $2,568.2万 | 22.5万股 | +19.2万股+85.12% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #166 | $4,076.0万 | 39.0万股 | $3,314.8万 | 29.0万股 | +9.9万股+34.15% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #188 | $3,975.7万 | 38.0万股 | $3,323.4万 | 29.1万股 | +8.9万股+30.51% | 加仓 |
| Saturn V Capital Management LP |
| 5.55% | 5.83% | #5 | $3,874.3万 | 37.0万股 | $3,217.7万 | 28.2万股 | +8.8万股+31.36% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.02% | 0.02% | #91 | $3,755.6万 | 35.9万股 | $2,638.2万 | 23.1万股 | +12.8万股+55.31% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #156 | $3,734.1万 | 35.7万股 | $3,638.4万 | 31.9万股 | +3.8万股+11.97% | 加仓 |
| LORD, ABBETT & CO. LLC |
| 0.11% | 0.16% | #56 | $3,686.5万 | 35.2万股 | $5,013.3万 | 43.9万股 | -8.7万股-19.77% | 减仓 |
| First Turn Management, LLC |
| 3.68% | 2.69% | #11 | $3,443.1万 | 32.9万股 | $2,403.5万 | 21.1万股 | +11.9万股+56.28% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | 0.01% | #155 | $3,357.2万 | 32.1万股 | $3,354.5万 | 29.4万股 | +2.7万股+9.19% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.18% | 0.2% | #43 | $3,179.0万 | 30.4万股 | $2,757.0万 | 24.2万股 | +6.2万股+25.80% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #132 | $3,118.2万 | 29.8万股 | $194.4万 | 1.7万股 | +28.1万股+1,649.72% | 加仓 |
| PFIZER INC |
| 17.35% | 13.13% | #1 | $2,955.0万 | 29.6万股 | $3,134.5万 | 29.6万股 | 00.00% | 持仓不变 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | 0.02% | #84 | $2,917.1万 | 27.9万股 | $1,520.2万 | 13.3万股 | +14.6万股+109.34% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #131 | $2,905.8万 | 27.8万股 | $2,891.9万 | 25.3万股 | +2.4万股+9.62% | 加仓 |
| Capitolis全球市场CAPITOLIS LIQUID GLOBAL MARKETS LLC |
| 0.13% | 0.23% | #51 | $2,899.0万 | 27.7万股 | $3,612.5万 | 31.7万股 | -3.9万股-12.45% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #170 | $2,585.2万 | 24.7万股 | $3,205.1万 | 28.1万股 | -3.4万股-12.00% | 减仓 |
| Focus Partners财富Focus Partners Wealth |
| 0.02% | 0.03% | #86 | $2,433.0万 | 23.3万股 | $2,663.9万 | 23.3万股 | -831股-0.36% | 减仓 |
