| Knoll Capital Management, LLC |
| 5.97% | 3.43% | #1 | $1,041.1万 | 588.2万股 | $647.0万 | 588.2万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 0.11% | — | #2 | $429.2万 | 242.5万股 | $0 | 0股 | +242.5万股 | 新买入 |
| Siren, L.L.C. |
| 0.03% | — | #5 | $130.4万 | 73.6万股 | $0 | 0股 | +73.6万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #12 | $65.3万 | 36.9万股 | $52.6万 | 47.3万股 | -10.5万股-22.09% | 减仓 |
| Parkman Healthcare Partners LLC |
| 0.05% | 0.03% | #4 | $48.6万 | 27.4万股 | $32.0万 | 28.9万股 | -1.4万股-4.91% | 减仓 |
| PNC金融服务集团PNC FINANCIAL SERVICES GROUP, INC. |
| <0.01% | <0.01% | #15 | $48.3万 | 27.3万股 | $1.1万 | 1.0万股 | +26.3万股+2,630.31% | 加仓 |
| Seven Fleet Capital Management LP |
| 0.06% | 0.07% | #3 | $33.9万 | 19.1万股 | $22.8万 | 20.6万股 | -1.4万股-6.90% | 减仓 |
| HighTower顾问HighTower Advisors, LLC |
| <0.01% | <0.01% | #17 | $13.3万 | 7.5万股 | $4.1万 | 3.7万股 | +3.8万股+102.48% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | <0.01% | #16 | $12.8万 | 7.2万股 | $1.7万 | 1.5万股 | +5.7万股+367.89% | 加仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| <0.01% | <0.01% | #14 | $10.4万 | 5.9万股 | $6.1万 | 5.5万股 | +3,648股+6.61% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #20 | $8.7万 | 4.9万股 | $27.3万 | 24.6万股 | -19.7万股-80.09% | 减仓 |
| TWO SIGMA SECURITIES, LLC |
| 0.01% | — | #7 | $8.6万 | 4.9万股 | $0 | 0股 | +4.9万股 | 新买入 |
| 签名地产投资顾问SIGNATURE ESTATE & INVESTMENT ADVISORS LLC |
| <0.01% | <0.01% | #11 | $8.4万 | 4.7万股 | $5.3万 | 4.7万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #21 | $6.7万 | 4.1万股 | $7,150 | 7,150股 | +3.4万股+471.79% | 加仓 |
| Virtu Financial LLC |
| <0.01% | — | #10 | $6.5万 | 3.7万股 | $0 | 0股 | +3.7万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #23 | $5.3万 | 3.0万股 | $2.3万 | 2.1万股 | +8,772股+41.50% | 加仓 |
| DIADEMA PARTNERS LP |
| 0.01% | <0.01% | #8 | $4.1万 | 2.3万股 | $2.6万 | 2.3万股 | 00.00% | 持仓不变 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #13 | $3.6万 | 2.1万股 | $14.6万 | 13.2万股 | -11.1万股-84.38% | 减仓 |
| Gem Investment Advisors, LLC |
| 0.02% | 0.04% | #6 | $3.4万 | 1.9万股 | $3.7万 | 1.9万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #24 | $3.1万 | 1.7万股 | $3.7万 | 3.3万股 | -1.6万股-47.35% | 减仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | — | #18 | $2.8万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| SG Americas Securities, LLC |
| <0.01% | — | #19 | $2.5万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #22 | $2.3万 | 1.3万股 | $3,565 | 3,212股 | +9,511股+296.11% | 加仓 |
| Persistent Asset Partners Ltd |
| <0.01% | <0.01% | #9 | $1.0万 | 5,881股 | $6,528 | 5,881股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #27 | $885 | 500股 | $0 | 0股 | +500股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | — | #25 | $708 | 400股 | $0 | 0股 | +400股 | 新买入 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #26 | $90 | 51股 | $57 | 51股 | 00.00% | 持仓不变 |
