| 富达投资FMR LLC |
| 0.04% | 0.04% | #75 | $9.90亿 | 1,799.5万股 | $8.48亿 | 1,724.3万股 | +75.2万股+4.36% | 加仓 |
| Siren, L.L.C. |
| 10.66% | 14.75% | #3 | $5.27亿 | 957.5万股 | $5.32亿 | 1,082.5万股 | -125.0万股-11.55% | 减仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #128 | $5.22亿 | 949.4万股 | $3.67亿 | 746.9万股 | +202.5万股+27.11% | 加仓 |
| Samsara BioCapital, LLC |
| 31.16% | 32.95% | #1 | $3.79亿 | 689.8万股 | $3.39亿 | 689.8万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.04% | 0.03% | #81 | $3.74亿 | 679.5万股 | $3.05亿 | 620.7万股 | +58.8万股+9.48% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.06% | 0.06% | #60 | $3.70亿 | 672.7万股 | $3.30亿 | 671.8万股 | +9,430股+0.14% | 加仓 |
| Orbis Allan GrayOrbis Allan Gray Ltd |
| 1.12% | 0.87% | #18 | $3.26亿 | 593.4万股 | $2.05亿 | 418.0万股 | +175.4万股+41.95% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #146 | $2.62亿 | 476.8万股 | $1.91亿 | 389.1万股 | +87.7万股+22.53% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #129 | $2.60亿 | 472.9万股 | $1.98亿 | 403.1万股 | +69.7万股+17.30% | 加仓 |
| Redmile Group, LLC |
| 15.92% | 29.51% | #2 | $2.37亿 | 431.1万股 | $4.46亿 | 906.7万股 | -475.6万股-52.45% | 减仓 |
| 挪威央行投资管理NORGES BANK |
| 0.02% | 0.01% | #108 | $1.52亿 | 277.0万股 | $5,251.5万 | 163.3万股 | +113.6万股+69.58% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #124 | $1.51亿 | 275.4万股 | $1.06亿 | 214.9万股 | +60.5万股+28.14% | 加仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.05% | — | #74 | $1.43亿 | 260.7万股 | $0 | 0股 | +260.7万股 | 新买入 |
| Bellevue 集团Bellevue Group AG |
| 2.83% | 4.19% | #6 | $1.35亿 | 245.0万股 | $1.76亿 | 358.5万股 | -113.5万股-31.66% | 减仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.08% | 0.11% | #57 | $1.30亿 | 235.9万股 | $1.64亿 | 334.0万股 | -98.2万股-29.39% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.05% | — | #69 | $1.23亿 | 224.2万股 | $0 | 0股 | +224.2万股 | 新买入 |
| Hood River资本管理Hood River Capital Management LLC |
| 0.89% | 1.01% | #21 | $1.22亿 | 222.5万股 | $1.01亿 | 205.0万股 | +17.5万股+8.54% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.7% | 0.69% | #22 | $1.21亿 | 220.6万股 | $9,439.9万 | 192.0万股 | +28.5万股+14.86% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 1.55% | 1.78% | #14 | $1.16亿 | 211.1万股 | $1.08亿 | 219.7万股 | -8.6万股-3.91% | 减仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.24% | 0.35% | #34 | $1.03亿 | 187.9万股 | $9,751.5万 | 198.4万股 | -10.5万股-5.30% | 减仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.22% | 0.22% | #35 | $9,657.9万 | 175.6万股 | $9,295.8万 | 189.1万股 | -13.5万股-7.14% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.13% | 0.05% | #45 | $9,522.7万 | 173.1万股 | $3,441.2万 | 70.0万股 | +103.1万股+147.34% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #160 | $8,463.3万 | 153.9万股 | $2,249.3万 | 60.4万股 | +93.5万股+154.76% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.26% | 0.28% | #32 | $8,252.6万 | 150.0万股 | $7,376.3万 | 150.0万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #137 | $7,763.1万 | 141.1万股 | $6,939.8万 | 141.2万股 | -206股-0.01% | 减仓 |
| 资本世界投资者Capital World Investors |
| 0.01% | 0.01% | #130 | $6,382.2万 | 116.0万股 | $5,548.9万 | 112.9万股 | +3.2万股+2.80% | 加仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.05% | 0.03% | #72 | $5,828.8万 | 106.0万股 | $3,399.0万 | 69.1万股 | +36.8万股+53.28% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #188 | $5,650.5万 | 102.7万股 | $3,548.1万 | 72.2万股 | +30.6万股+42.34% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.05% | — | #65 | $5,389.1万 | 98.0万股 | $0 | 0股 | +98.0万股 | 新买入 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #92 | $5,363.6万 | 97.5万股 | $3,476.1万 | 70.7万股 | +26.8万股+37.91% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | <0.01% | #142 | $5,360.2万 | 97.5万股 | $3,754.9万 | 76.4万股 | +21.1万股+27.60% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #174 | $5,347.4万 | 97.2万股 | $6,570.9万 | 133.7万股 | -36.4万股-27.26% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.05% | 0.05% | #73 | $5,010.6万 | 91.1万股 | $4,301.9万 | 87.5万股 | +3.6万股+4.11% | 加仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.04% | 0.04% | #76 | $4,898.3万 | 89.1万股 | $3,566.1万 | 72.5万股 | +16.5万股+22.77% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #116 | $4,833.0万 | 87.9万股 | $132.2万 | 2.7万股 | +85.2万股+3,168.83% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #140 | $4,753.6万 | 86.4万股 | $3,446.2万 | 70.1万股 | +16.3万股+23.29% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 1.63% | 1.18% | #12 | $4,125.0万 | 75.0万股 | $2,458.0万 | 50.0万股 | +25.0万股+50.00% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.06% | 0.06% | #62 | $4,039.8万 | 73.5万股 | $3,922.5万 | 79.8万股 | -6.3万股-7.95% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #120 | $4,015.5万 | 73.0万股 | $2,895.8万 | 58.9万股 | +14.1万股+23.94% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.02% | #97 | $3,946.3万 | 71.8万股 | $3,558.6万 | 72.4万股 | -6,363股-0.88% | 减仓 |
| Rock Springs Capital Management LP |
| 1.92% | 2.14% | #7 | $3,935.0万 | 71.5万股 | $3,636.9万 | 74.0万股 | -2.4万股-3.29% | 减仓 |
| Casdin Capital, LLC |
| 1.83% | 1.3% | #9 | $3,657.5万 | 66.5万股 | $1,720.6万 | 35.0万股 | +31.5万股+90.00% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | 0.01% | #122 | $3,584.6万 | 65.2万股 | $2,859.4万 | 58.2万股 | +7.0万股+12.05% | 加仓 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.04% | 0.04% | #78 | $3,278.3万 | 59.6万股 | $3,139.5万 | 63.9万股 | -4.3万股-6.67% | 减仓 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.05% | 0.07% | #68 | $3,184.8万 | 57.9万股 | $3,526.0万 | 71.7万股 | -13.8万股-19.27% | 减仓 |
| Eagle Health Investments LP |
| 5.06% | 4.25% | #4 | $3,054.0万 | 55.5万股 | $2,428.6万 | 49.4万股 | +6.1万股+12.40% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | 0.01% | #171 | $2,811.4万 | 51.1万股 | $3,341.8万 | 68.0万股 | -16.9万股-24.80% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.02% | — | #93 | $2,550.5万 | 46.4万股 | $0 | 0股 | +46.4万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #181 | $2,528.1万 | 46.0万股 | $4,849.6万 | 98.6万股 | -52.7万股-53.41% | 减仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.01% | 0.01% | #133 | $2,417.0万 | 43.9万股 | $2,251.6万 | 45.8万股 | -1.9万股-4.05% | 减仓 |
