| 贝莱德BlackRock, Inc. |
| 0.01% | <0.01% | #128 | $8.60亿 | 1,078.9万股 | $2.07亿 | 548.9万股 | +529.9万股+96.54% | 加仓 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 3.08% | 1.86% | #10 | $6.67亿 | 836.5万股 | $3.27亿 | 865.6万股 | -29.1万股-3.36% | 减仓 |
| Caligan Partners LP |
| 30.45% | 20.39% | #3 | $6.47亿 | 811.9万股 | $3.06亿 | 811.9万股 | 00.00% | 持仓不变 |
| FINDELL CAPITAL MANAGEMENT LLC |
| 53.91% | 39.26% | #1 | $3.83亿 | 480.2万股 | $1.34亿 | 355.2万股 | +125.0万股+35.19% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #180 | $2.50亿 | 313.9万股 | $1.10亿 | 292.7万股 | +21.2万股+7.25% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #158 | $2.42亿 | 303.0万股 | $7,101.2万 | 188.2万股 | +114.9万股+61.05% | 加仓 |
| Opaleye Management Inc. |
| 17.67% | 11.7% | #5 | $1.95亿 | 244.8万股 | $8,882.1万 | 254.5万股 | -9.8万股-3.83% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #148 | $1.69亿 | 212.1万股 | $7,281.2万 | 192.9万股 | +19.2万股+9.97% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #140 | $1.59亿 | 199.2万股 | $8,634.1万 | 228.8万股 | -29.6万股-12.95% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.02% | 0.01% | #111 | $1.55亿 | 194.6万股 | $7,227.3万 | 191.5万股 | +3.1万股+1.60% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | <0.01% | #121 | $1.55亿 | 194.0万股 | $3,597.3万 | 95.3万股 | +98.7万股+103.57% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #134 | $1.46亿 | 182.7万股 | $6,255.7万 | 165.8万股 | +16.9万股+10.22% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #177 | $1.22亿 | 153.2万股 | $2,387.5万 | 63.3万股 | +90.0万股+142.19% | 加仓 |
| 顶岩集团Caprock Group, LLC |
| 2.15% | 1.25% | #11 | $1.12亿 | 141.0万股 | $5,159.9万 | 136.7万股 | +4.3万股+3.11% | 加仓 |
| MPM BioImpact LLC |
| 6.74% | 4.1% | #7 | $1.11亿 | 138.6万股 | $5,303.1万 | 140.5万股 | -1.9万股-1.35% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.05% | 0.02% | #82 | $1.08亿 | 135.8万股 | $3,431.6万 | 90.9万股 | +44.9万股+49.37% | 加仓 |
| Fuller & Thaler资产管理FULLER & THALER ASSET MANAGEMENT, INC. |
| 0.26% | — | #40 | $9,644.2万 | 121.0万股 | $0 | 0股 | +121.0万股 | 新买入 |
| Buckley Capital Advisors, LLC |
| 37.81% | 32.1% | #2 | $7,786.0万 | 97.3万股 | $4,467.1万 | 118.4万股 | -21.0万股-17.78% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| 0.01% | 0.01% | #165 | $7,770.0万 | 97.5万股 | $4,989.5万 | 132.2万股 | -34.8万股-26.29% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #161 | $7,645.2万 | 95.9万股 | $3,064.5万 | 81.2万股 | +14.7万股+18.09% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.09% | 0.03% | #68 | $6,507.5万 | 81.6万股 | $1,655.9万 | 43.9万股 | +37.7万股+86.02% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | <0.01% | #162 | $5,653.4万 | 70.9万股 | $2,188.4万 | 58.0万股 | +12.9万股+22.28% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #159 | $5,374.1万 | 67.4万股 | $2,102.9万 | 55.7万股 | +11.7万股+20.97% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #224 | $5,249.8万 | 65.8万股 | $2,289.3万 | 100.7万股 | -34.8万股-34.59% | 减仓 |
| Caption管理Caption Management, LLC |
| 0.24% | 0.08% | #42 | $5,206.4万 | 65.3万股 | $1,383.5万 | 36.7万股 | +28.6万股+78.12% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.66% | 0.31% | #24 | $4,964.9万 | 62.3万股 | $2,358.9万 | 62.5万股 | -2,332股-0.37% | 减仓 |
| 瑞银集团UBS Group AG |
| 0.01% | <0.01% | #169 | $4,836.1万 | 60.7万股 | $782.1万 | 20.7万股 | +39.9万股+192.69% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #240 | $4,749.0万 | 59.6万股 | $2,197.2万 | 58.2万股 | +1.3万股+2.31% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | — | #109 | $4,322.4万 | 54.2万股 | $0 | 0股 | +54.2万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #150 | $4,016.6万 | 50.4万股 | $1,782.4万 | 47.2万股 | +3.2万股+6.67% | 加仓 |
| Eversept Partners, LP |
| 1.77% | 1.35% | #15 | $3,417.6万 | 42.9万股 | $2,556.5万 | 67.7万股 | -24.9万股-36.72% | 减仓 |
| 奥伯维斯资产管理OBERWEIS ASSET MANAGEMENT INC/ |
| 0.67% | 0.41% | #23 | $3,240.2万 | 40.6万股 | $1,404.3万 | 37.2万股 | +3.4万股+9.22% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #229 | $3,229.8万 | 40.5万股 | $1,817.0万 | 48.1万股 | -7.6万股-15.86% | 减仓 |
| Purewater Capital LLC |
| 21.91% | 13.31% | #4 | $3,036.1万 | 39.0万股 | $1,394.2万 | 37.8万股 | +1.2万股+3.27% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #188 | $2,969.4万 | 37.2万股 | $731.9万 | 19.4万股 | +17.9万股+92.06% | 加仓 |
| 巴克莱BARCLAYS PLC |
| 0.01% | <0.01% | #176 | $2,948.9万 | 37.0万股 | $123.8万 | 3.3万股 | +33.7万股+1,027.39% | 加仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | — | #127 | $2,738.3万 | 34.3万股 | $0 | 0股 | +34.3万股 | 新买入 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #170 | $2,523.4万 | 31.6万股 | $574.5万 | 15.2万股 | +16.4万股+107.91% | 加仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | 0.01% | #123 | $2,403.3万 | 30.1万股 | $1,054.7万 | 27.9万股 | +2.2万股+7.86% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.02% | #120 | $2,127.4万 | 26.7万股 | $2,125.6万 | 56.3万股 | -29.6万股-52.63% | 减仓 |
| Seven Fleet Capital Management LP |
| 3.38% | 2.25% | #9 | $2,045.9万 | 25.7万股 | $709.0万 | 18.8万股 | +6.9万股+36.58% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.01% | — | #152 | $2,000.7万 | 25.1万股 | $0 | 0股 | +25.1万股 | 新买入 |
| 加拿大公共部门养老金投资委员会(PSP)PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.05% | — | #85 | $1,924.5万 | 24.1万股 | $0 | 0股 | +24.1万股 | 新买入 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.07% | — | #74 | $1,919.5万 | 24.1万股 | $0 | 0股 | +24.1万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #212 | $1,910.0万 | 24.0万股 | $0 | 0股 | +24.0万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.03% | <0.01% | #96 | $1,852.6万 | 23.2万股 | $30.6万 | 8,100股 | +22.4万股+2,768.56% | 加仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #187 | $1,800.8万 | 22.6万股 | $613.1万 | 16.2万股 | +6.3万股+39.03% | 加仓 |
| Empowered FundsEmpowered Funds, LLC |
| 0.09% | 0.02% | #69 | $1,677.2万 | 21.0万股 | $365.0万 | 9.7万股 | +11.4万股+117.51% | 加仓 |
| 花旗集团CITIGROUP INC |
| 0.01% | <0.01% | #179 | $1,649.5万 | 20.7万股 | $735.0万 | 19.5万股 | +1.2万股+6.23% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.18% | 0.12% | #50 | $1,529.5万 | 19.2万股 | $770.1万 | 20.4万股 | -1.2万股-5.99% | 减仓 |
