| 富达投资FMR LLC |
| 0.03% | 0.02% | #109 | $6.76亿 | 1,762.9万股 | $3.77亿 | 1,774.1万股 | -11.2万股-0.63% | 减仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | <0.01% | #198 | $4.14亿 | 1,080.4万股 | $2.14亿 | 1,008.0万股 | +72.4万股+7.18% | 加仓 |
| ARK投资管理ARK Investment Management LLC |
| 2.48% | 1.93% | #4 | $3.84亿 | 1,000.3万股 | $2.49亿 | 1,171.7万股 | -171.4万股-14.63% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #147 | $2.68亿 | 698.2万股 | $1.47亿 | 691.3万股 | +7.0万股+1.01% | 加仓 |
| Quantinno资本管理Quantinno Capital Management LP |
| 0.25% | 0.19% | #28 | $2.10亿 | 547.0万股 | $1.15亿 | 541.2万股 | +5.8万股+1.07% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #223 | $1.95亿 | 508.3万股 | $1.12亿 | 527.0万股 | -18.7万股-3.55% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | <0.01% | #129 | $1.74亿 | 453.9万股 | $346.6万 | 16.3万股 | +437.6万股+2,681.00% | 加仓 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| 0.09% | 0.07% | #62 | $1.61亿 | 419.5万股 | $1.08亿 | 511.0万股 | -91.6万股-17.92% | 减仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 2.08% | 1.53% | #8 | $1.61亿 | 419.3万股 | $1.08亿 | 510.4万股 | -91.2万股-17.86% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #189 | $1.29亿 | 335.2万股 | $3,293.4万 | 281.7万股 | +53.5万股+18.98% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #154 | $1.21亿 | 314.9万股 | $8,723.6万 | 410.9万股 | -96.0万股-23.37% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #196 | $1.18亿 | 308.3万股 | $6,166.9万 | 290.4万股 | +17.9万股+6.15% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #145 | $1.14亿 | 296.6万股 | $1,978.1万 | 93.2万股 | +203.5万股+218.36% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #238 | $1.07亿 | 280.1万股 | $5,496.0万 | 258.9万股 | +21.3万股+8.21% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.02% | 0.01% | #136 | $8,530.6万 | 222.5万股 | $4,335.7万 | 204.3万股 | +18.2万股+8.93% | 加仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.28% | 0.2% | #26 | $7,744.2万 | 202.0万股 | $4,847.7万 | 228.3万股 | -26.4万股-11.54% | 减仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.03% | 0.02% | #112 | $7,469.5万 | 202.6万股 | $5,365.9万 | 253.8万股 | -51.2万股-20.16% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.08% | — | #67 | $7,103.5万 | 185.3万股 | $0 | 0股 | +185.3万股 | 新买入 |
| 资本世界投资者Capital World Investors |
| 0.01% | <0.01% | #190 | $5,724.3万 | 149.3万股 | $3,083.2万 | 145.2万股 | +4.1万股+2.80% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.03% | 0.02% | #105 | $4,857.5万 | 126.7万股 | $2,716.2万 | 127.9万股 | -1.2万股-0.97% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | <0.01% | #210 | $4,386.2万 | 114.4万股 | $2,224.9万 | 104.8万股 | +9.6万股+9.16% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #155 | $4,311.8万 | 112.5万股 | $1,328.6万 | 62.6万股 | +49.9万股+79.71% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #204 | $4,168.1万 | 108.7万股 | $2,392.7万 | 112.7万股 | -4.0万股-3.54% | 减仓 |
| Casdin Capital, LLC |
| 2.02% | 3.66% | #9 | $4,025.7万 | 105.0万股 | $4,829.8万 | 227.5万股 | -122.5万股-53.85% | 减仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.07% | 0.05% | #71 | $3,789.2万 | 98.8万股 | $1,992.2万 | 93.8万股 | +5.0万股+5.32% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #252 | $3,721.9万 | 97.1万股 | $2,047.8万 | 96.5万股 | +6,195股+0.64% | 加仓 |
| Anomaly 资本管理Anomaly Capital Management, LP |
| 1.27% | — | #12 | $3,327.1万 | 86.8万股 | $0 | 0股 | +86.8万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #244 | $3,279.6万 | 85.5万股 | $123.1万 | 5.8万股 | +79.7万股+1,374.83% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #186 | $3,202.2万 | 83.5万股 | $1,653.6万 | 77.9万股 | +5.6万股+7.23% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.03% | #90 | $3,075.0万 | 80.2万股 | $2,141.6万 | 100.9万股 | -20.7万股-20.49% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #282 | $2,816.5万 | 75.3万股 | $1,556.1万 | 78.6万股 | -3.2万股-4.13% | 减仓 |
| Blue Water Life Science Advisors, LP |
| 15.5% | 18.56% | #1 | $2,461.4万 | 64.2万股 | $2,314.1万 | 109.0万股 | -44.8万股-41.10% | 减仓 |
| Freshford Capital Management, LLC |
| 7.88% | 7.14% | #2 | $2,302.0万 | 60.0万股 | $1,428.7万 | 67.3万股 | -7.3万股-10.78% | 减仓 |
| 罗素投资集团Russell Investments Group, Ltd. |
| 0.02% | 0.01% | #132 | $2,163.6万 | 56.4万股 | $1,020.4万 | 48.1万股 | +8.4万股+17.41% | 加仓 |
| CLOUGH CAPITAL PARTNERS L P |
| 1.72% | — | #11 | $2,108.6万 | 55.0万股 | $0 | 0股 | +55.0万股 | 新买入 |
| 汇丰控股HSBC HOLDINGS PLC |
| 0.01% | <0.01% | #170 | $2,029.4万 | 53.7万股 | $594.5万 | 28.5万股 | +25.2万股+88.17% | 加仓 |
| IEQ资本IEQ CAPITAL, LLC |
| 0.09% | 0.07% | #61 | $2,018.2万 | 52.6万股 | $1,487.6万 | 70.1万股 | -17.4万股-24.87% | 减仓 |
| 萨姆林资本SAMLYN CAPITAL, LLC |
| 0.31% | — | #22 | $1,932.5万 | 50.4万股 | $0 | 0股 | +50.4万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #251 | $1,897.3万 | 49.5万股 | $1,050.4万 | 49.5万股 | +106股+0.02% | 加仓 |
| Sands Capital Alternatives, LLC |
| 3.01% | 2.43% | #3 | $1,847.1万 | 48.2万股 | $1,022.8万 | 48.2万股 | 00.00% | 持仓不变 |
| 魁北克储蓄投资集团(CDPQ)CAISSE DE DEPOT ET PLACEMENT DU QUEBEC |
| 0.02% | 0.01% | #115 | $1,709.9万 | 44.6万股 | $350.8万 | 16.5万股 | +28.1万股+169.88% | 加仓 |
| Meridiem Capital Partners LP |
| 0.73% | 0.72% | #15 | $1,618.8万 | 42.2万股 | $1,112.4万 | 52.4万股 | -10.2万股-19.42% | 减仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.01% | <0.01% | #162 | $1,590.7万 | 41.5万股 | $27.1万 | 1.3万股 | +40.2万股+3,151.78% | 加仓 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 0.99% | 0.87% | #13 | $1,550.3万 | 40.4万股 | $1,152.3万 | 54.3万股 | -13.8万股-25.50% | 减仓 |
| 杜肯家族办公室Duquesne Family Office LLC |
| 0.3% | — | #24 | $1,545.5万 | 40.3万股 | $0 | 0股 | +40.3万股 | 新买入 |
| LORD, ABBETT & CO. LLC |
| 0.04% | 0.02% | #88 | $1,525.4万 | 39.8万股 | $699.1万 | 32.9万股 | +6.9万股+20.82% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #299 | $1,489.6万 | 38.9万股 | $674.4万 | 31.8万股 | +7.1万股+22.31% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #300 | $1,487.3万 | 38.8万股 | $994.8万 | 46.9万股 | -8.1万股-17.21% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #256 | $1,394.2万 | 36.4万股 | $737.9万 | 34.8万股 | +1.6万股+4.62% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.01% | <0.01% | #205 | $1,236.4万 | 32.2万股 | $620.3万 | 29.2万股 | +3.0万股+10.36% | 加仓 |
