| 富达投资FMR LLC |
| 0.05% | 0.03% | #76 | $11.56亿 | 1,302.6万股 | $5.94亿 | 1,178.1万股 | +124.5万股+10.57% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | <0.01% | #126 | $5.78亿 | 650.7万股 | $2.78亿 | 552.1万股 | +98.5万股+17.85% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 5.76% | 3.73% | #6 | $3.83亿 | 431.9万股 | $1.91亿 | 378.3万股 | +53.6万股+14.17% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 3.22% | 2.09% | #10 | $3.77亿 | 425.2万股 | $2.10亿 | 417.2万股 | +8.0万股+1.92% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 6.38% | 2.02% | #5 | $3.41亿 | 384.1万股 | $9,872.4万 | 195.7万股 | +188.4万股+96.23% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | <0.01% | #143 | $3.06亿 | 344.9万股 | $1.54亿 | 305.7万股 | +39.1万股+12.80% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #132 | $2.71亿 | 305.7万股 | $1.31亿 | 260.7万股 | +45.0万股+17.28% | 加仓 |
| Venrock Adviser, LLC |
| 8.04% | 6.94% | #2 | $2.65亿 | 298.5万股 | $1.86亿 | 368.5万股 | -70.0万股-18.99% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.01% | #89 | $2.63亿 | 296.1万股 | $8,064.1万 | 159.9万股 | +136.2万股+85.20% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.44% | 1.03% | #15 | $2.49亿 | 279.9万股 | $1.41亿 | 279.1万股 | +8,381股+0.30% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #111 | $2.39亿 | 256.2万股 | $8,681.9万 | 172.1万股 | +84.1万股+48.89% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #122 | $2.07亿 | 233.0万股 | $2,951.4万 | 58.5万股 | +174.5万股+298.22% | 加仓 |
| 资本世界投资者Capital World Investors |
| 0.02% | <0.01% | #90 | $2.06亿 | 231.6万股 | $3,362.1万 | 66.7万股 | +164.9万股+247.39% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.08% | — | #65 | $1.96亿 | 220.7万股 | $0 | 0股 | +220.7万股 | 新买入 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 4.06% | 2.74% | #9 | $1.69亿 | 190.1万股 | $9,586.5万 | 190.1万股 | 00.00% | 持仓不变 |
| TANG CAPITAL MANAGEMENT LLC |
| 7.63% | 4.85% | #3 | $1.68亿 | 189.2万股 | $9,544.3万 | 189.2万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #120 | $1.58亿 | 177.8万股 | $6,194.5万 | 122.8万股 | +55.0万股+44.77% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.21% | — | #42 | $1.53亿 | 172.2万股 | $0 | 0股 | +172.2万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | 0.02% | #91 | $1.40亿 | 158.2万股 | $9,204.3万 | 182.5万股 | -24.3万股-13.33% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #114 | $1.31亿 | 147.8万股 | $1,361.6万 | 27.0万股 | +120.8万股+447.55% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.03% | 0.01% | #88 | $1.31亿 | 147.3万股 | $4,453.0万 | 88.3万股 | +59.0万股+66.84% | 加仓 |
| Remedium Capital Partners, LLC |
| 28.78% | 26.13% | #1 | $1.30亿 | 146.4万股 | $7,345.2万 | 145.6万股 | +7,938股+0.55% | 加仓 |
| Affinity Asset Advisors, LLC |
| 5.13% | 3.33% | #7 | $1.14亿 | 127.9万股 | $6,452.0万 | 127.9万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| 0.01% | <0.01% | #153 | $9,887.1万 | 109.3万股 | $4,448.0万 | 97.9万股 | +11.4万股+11.61% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.2% | — | #44 | $9,012.7万 | 101.5万股 | $0 | 0股 | +101.5万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.07% | 0.01% | #70 | $8,804.3万 | 99.2万股 | $702.4万 | 13.9万股 | +85.2万股+612.12% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.21% | 0.14% | #43 | $8,771.5万 | 98.8万股 | $3,999.1万 | 79.3万股 | +19.5万股+24.62% | 加仓 |
| Siren, L.L.C. |
| 1.74% | 1.14% | #13 | $8,599.2万 | 96.9万股 | $4,129.0万 | 81.9万股 | +15.0万股+18.32% | 加仓 |
| 资本国际投资者Capital International Investors |
| 0.02% | 0.02% | #97 | $8,480.2万 | 95.5万股 | $8,807.5万 | 174.6万股 | -79.1万股-45.30% | 减仓 |
| BRAIDWELL LP |
| 2.89% | 1.57% | #12 | $7,807.9万 | 87.9万股 | $4,705.2万 | 93.3万股 | -5.3万股-5.72% | 减仓 |
| Commodore Capital LP |
| 4.48% | 5.58% | #8 | $7,517.8万 | 84.7万股 | $9,646.0万 | 191.2万股 | -106.6万股-55.72% | 减仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #121 | $7,484.8万 | 84.3万股 | $3,385.7万 | 67.1万股 | +17.2万股+25.60% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | <0.01% | #138 | $5,988.5万 | 67.5万股 | $2,920.0万 | 57.9万股 | +9.6万股+16.52% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #134 | $5,797.0万 | 65.3万股 | $2,838.0万 | 56.3万股 | +9.0万股+16.05% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.05% | 0.03% | #75 | $5,576.6万 | 62.8万股 | $2,479.9万 | 49.2万股 | +13.6万股+27.76% | 加仓 |
| EMERALD ADVISERS, LLC |
| 1.19% | 0.98% | #19 | $5,037.6万 | 56.7万股 | $3,093.8万 | 61.3万股 | -4.6万股-7.49% | 减仓 |
| 胜利资本管理VICTORY CAPITAL MANAGEMENT INC |
| 0.03% | 0.01% | #86 | $4,918.2万 | 55.4万股 | $1,473.5万 | 29.2万股 | +26.2万股+89.64% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #117 | $4,895.2万 | 55.1万股 | $2,343.7万 | 46.5万股 | +8.7万股+18.67% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.22% | 0.07% | #41 | $4,845.5万 | 54.6万股 | $1,394.1万 | 42.6万股 | +12.1万股+28.38% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | <0.01% | #129 | $4,634.9万 | 52.2万股 | $1,045.7万 | 20.7万股 | +31.5万股+151.83% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #178 | $4,438.7万 | 50.0万股 | $561.0万 | 33.5万股 | +16.5万股+49.37% | 加仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | <0.01% | #82 | $3,832.6万 | 43.2万股 | $272.2万 | 5.4万股 | +37.8万股+699.88% | 加仓 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 1.25% | 1% | #18 | $3,562.5万 | 40.1万股 | $2,058.5万 | 40.8万股 | -6,842股-1.68% | 减仓 |
| 萨姆林资本SAMLYN CAPITAL, LLC |
| 0.58% | 0.34% | #27 | $3,551.9万 | 40.0万股 | $2,000.8万 | 39.7万股 | +3,414股+0.86% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #174 | $3,417.2万 | 38.5万股 | $648.0万 | 12.8万股 | +25.6万股+199.63% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.01% | <0.01% | #146 | $3,161.3万 | 35.6万股 | $803.1万 | 15.9万股 | +19.7万股+123.65% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 1.14% | — | #21 | $2,885.4万 | 32.5万股 | $0 | 0股 | +32.5万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.08% | 0.05% | #62 | $2,717.1万 | 30.6万股 | $1,341.2万 | 26.6万股 | +4.0万股+15.10% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.02% | — | #101 | $2,691.6万 | 30.3万股 | $0 | 0股 | +30.3万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 1.16% | 1% | #20 | $2,521.2万 | 28.4万股 | $1,706.5万 | 33.8万股 | -5.4万股-16.06% | 减仓 |
