| 贝莱德BlackRock, Inc. |
| 0.01% | <0.01% | #169 | $5.28亿 | 1,123.3万股 | $1.60亿 | 848.0万股 | +275.3万股+32.46% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 3.04% | 0.93% | #10 | $3.38亿 | 718.9万股 | $9,450.0万 | 500.0万股 | +218.9万股+43.78% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.87% | 0.82% | #16 | $3.22亿 | 684.5万股 | $1.12亿 | 591.2万股 | +93.3万股+15.79% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.11% | — | #72 | $2.64亿 | 561.6万股 | $0 | 0股 | +561.6万股 | 新买入 |
| 资本世界投资者Capital World Investors |
| 0.03% | — | #117 | $2.52亿 | 536.8万股 | $0 | 0股 | +536.8万股 | 新买入 |
| 富达投资FMR LLC |
| 0.01% | <0.01% | #161 | $2.24亿 | 475.3万股 | $3,420.2万 | 181.0万股 | +294.3万股+162.65% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | <0.01% | #132 | $2.19亿 | 465.2万股 | $132.4万 | 7.0万股 | +458.2万股+6,545.67% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #162 | $1.71亿 | 364.5万股 | $4,717.3万 | 249.5万股 | +114.9万股+46.06% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #206 | $1.44亿 | 306.5万股 | $4,671.8万 | 247.2万股 | +59.4万股+24.01% | 加仓 |
| 资本国际投资者Capital International Investors |
| 0.03% | — | #119 | $1.39亿 | 296.3万股 | $0 | 0股 | +296.3万股 | 新买入 |
| Octagon Capital Advisors LP |
| 12.47% | 5.1% | #2 | $1.39亿 | 295.0万股 | $4,611.6万 | 244.0万股 | +51.0万股+20.90% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.02% | <0.01% | #130 | $1.39亿 | 295.0万股 | $2,466.0万 | 130.5万股 | +164.5万股+126.08% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 1.88% | 0.93% | #15 | $1.29亿 | 275.0万股 | $5,670.0万 | 300.0万股 | -25.0万股-8.33% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #154 | $1.06亿 | 226.1万股 | $2,814.7万 | 148.9万股 | +77.2万股+51.83% | 加仓 |
| Commodore Capital LP |
| 5.6% | 2.19% | #4 | $9,408.0万 | 200.0万股 | $3,780.0万 | 200.0万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | <0.01% | #178 | $8,929.9万 | 189.8万股 | $2,150.2万 | 113.8万股 | +76.1万股+66.87% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.03% | <0.01% | #120 | $8,475.4万 | 180.3万股 | $173.3万 | 9.2万股 | +171.2万股+1,866.44% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #171 | $8,471.2万 | 180.1万股 | $3,166.5万 | 167.5万股 | +12.5万股+7.49% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #217 | $7,754.2万 | 164.8万股 | $1,649.3万 | 87.3万股 | +77.6万股+88.90% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.61% | — | #33 | $7,056.0万 | 150.0万股 | $0 | 0股 | +150.0万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #250 | $6,992.3万 | 148.6万股 | $2,073.3万 | 109.7万股 | +38.9万股+35.50% | 加仓 |
| Siren, L.L.C. |
| 1.35% | 0.48% | #19 | $6,677.3万 | 141.9万股 | $1,737.8万 | 91.9万股 | +50.0万股+54.38% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.05% | 0.02% | #104 | $6,110.2万 | 129.9万股 | $2,269.6万 | 120.1万股 | +9.8万股+8.17% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | <0.01% | #185 | $5,500.1万 | 116.9万股 | $1,510.1万 | 79.9万股 | +37.0万股+46.34% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.01% | <0.01% | #158 | $5,401.9万 | 114.8万股 | $1,826.9万 | 96.7万股 | +18.2万股+18.80% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #152 | $5,199.4万 | 110.5万股 | $1,319.5万 | 69.8万股 | +40.7万股+58.32% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | <0.01% | #180 | $5,097.1万 | 108.4万股 | $1,528.5万 | 80.9万股 | +27.5万股+33.99% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.15% | 0.05% | #67 | $4,721.1万 | 100.4万股 | $1,422.8万 | 75.3万股 | +25.1万股+33.32% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.07% | 0.03% | #89 | $4,704.0万 | 100.0万股 | $2,173.5万 | 115.0万股 | -15.0万股-13.04% | 减仓 |
| Boxer Capital Management, LLC |
| 3.54% | 1.49% | #8 | $4,696.9万 | 99.9万股 | $1,131.2万 | 59.9万股 | +40.0万股+66.83% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.03% | 0.02% | #115 | $4,336.2万 | 92.2万股 | $2,271.0万 | 120.2万股 | -28.0万股-23.28% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.05% | 0.03% | #97 | $4,222.6万 | 89.8万股 | $2,408.3万 | 127.4万股 | -37.7万股-29.55% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #164 | $3,893.5万 | 82.8万股 | $1,088.5万 | 57.6万股 | +25.2万股+43.71% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.08% | 0.05% | #82 | $3,747.1万 | 79.7万股 | $2,063.8万 | 109.2万股 | -29.5万股-27.05% | 减仓 |
| AWM Investment Company, Inc. |
| 3.2% | 2.25% | #9 | $3,691.7万 | 78.5万股 | $2,035.3万 | 107.7万股 | -29.2万股-27.12% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.01% | <0.01% | #192 | $3,656.3万 | 77.7万股 | $1,423.0万 | 75.3万股 | +2.4万股+3.23% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.09% | — | #81 | $3,656.2万 | 77.7万股 | $0 | 0股 | +77.7万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #224 | $3,535.5万 | 75.2万股 | $656.7万 | 34.7万股 | +40.4万股+116.32% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.45% | 0.21% | #39 | $3,339.8万 | 71.0万股 | $1,296.8万 | 68.6万股 | +2.4万股+3.47% | 加仓 |
| 纽伯格伯曼集团Neuberger Berman Group LLC |
| 0.02% | <0.01% | #133 | $3,234.2万 | 68.8万股 | $252.1万 | 13.3万股 | +55.4万股+415.52% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.03% | 0.01% | #116 | $3,212.4万 | 68.3万股 | $805.2万 | 42.6万股 | +25.7万股+60.28% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.13% | 0.07% | #70 | $2,887.5万 | 61.4万股 | $1,300.5万 | 97.1万股 | -35.7万股-36.74% | 减仓 |
| ArrowMark Colorado Holdings LLC |
| 1.1% | 0.8% | #23 | $2,653.4万 | 56.4万股 | $3,014.0万 | 159.5万股 | -103.1万股-64.63% | 减仓 |
| Catalio Capital Management, LP |
| 4.97% | 4.1% | #6 | $2,646.8万 | 56.3万股 | $1,961.8万 | 103.8万股 | -47.5万股-45.79% | 减仓 |
| 黑石集团Blackstone Inc. |
| 0.08% | 0.04% | #84 | $2,641.8万 | 56.2万股 | $961.4万 | 50.9万股 | +5.3万股+10.41% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 1.02% | 0.36% | #24 | $2,587.2万 | 55.0万股 | $756.0万 | 40.0万股 | +15.0万股+37.50% | 加仓 |
| BAMCO(巴伦基金)BAMCO INC /NY/ |
| 0.04% | — | #109 | $2,446.6万 | 52.0万股 | $0 | 0股 | +52.0万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #222 | $2,349.5万 | 49.9万股 | $933.6万 | 49.4万股 | +5,490股+1.11% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | — | #204 | $2,287.2万 | 48.6万股 | $0 | 0股 | +48.6万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.03% | <0.01% | #128 | $2,276.6万 | 48.4万股 | $331.7万 | 17.5万股 | +30.8万股+175.79% | 加仓 |
