| ARK投资管理ARK Investment Management LLC |
| 3.34% | 4.19% | #6 | $5.16亿 | 946.1万股 | $5.38亿 | 1,131.4万股 | -185.3万股-16.38% | 减仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #198 | $4.55亿 | 834.9万股 | $3.65亿 | 768.0万股 | +66.9万股+8.71% | 加仓 |
| Orbis Allan GrayOrbis Allan Gray Ltd |
| 1.02% | 1.23% | #12 | $2.97亿 | 544.9万股 | $2.90亿 | 610.6万股 | -65.7万股-10.76% | 减仓 |
| 资本世界投资者Capital World Investors |
| 0.03% | 0.03% | #110 | $2.59亿 | 475.0万股 | $2.25亿 | 472.5万股 | +2.4万股+0.52% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #194 | $2.36亿 | 432.2万股 | $1.89亿 | 398.3万股 | +33.9万股+8.52% | 加仓 |
| GSK plc |
| 29.17% | 25.57% | #1 | $1.76亿 | 322.1万股 | $1.53亿 | 322.1万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #193 | $1.37亿 | 251.0万股 | $1.13亿 | 237.7万股 | +13.3万股+5.58% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.07% | 0.1% | #74 | $1.12亿 | 205.3万股 | $1.40亿 | 295.3万股 | -90.0万股-30.47% | 减仓 |
| SR ONE CAPITAL MANAGEMENT, LP |
| 10.7% | 10.59% | #2 | $1.11亿 | 203.9万股 | $9,698.4万 | 203.9万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.08% | 0.06% | #70 | $1.08亿 | 198.9万股 | $7,054.9万 | 148.3万股 | +50.6万股+34.09% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #243 | $1.04亿 | 190.9万股 | $9,298.5万 | 195.5万股 | -4.6万股-2.36% | 减仓 |
| 三井住友信托集团Sumitomo Mitsui Trust Group, Inc. |
| 0.05% | 0.06% | #84 | $9,384.9万 | 172.1万股 | $8,818.9万 | 185.4万股 | -13.3万股-7.18% | 减仓 |
| Amova资产管理Amova Asset Management Americas, Inc. |
| 1.21% | 1.25% | #11 | $9,376.2万 | 172.0万股 | $8,818.9万 | 185.4万股 | -13.4万股-7.22% | 减仓 |
| EcoR1 Capital, LLC |
| 3.68% | 2.8% | #4 | $7,577.1万 | 138.9万股 | $6,608.8万 | 138.9万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #175 | $7,199.3万 | 132.0万股 | $8,384.4万 | 176.3万股 | -44.3万股-25.11% | 减仓 |
| 资本国际投资者Capital International Investors |
| 0.01% | 0.01% | #139 | $6,917.9万 | 126.8万股 | $5,645.6万 | 118.7万股 | +8.2万股+6.88% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #356 | $6,445.8万 | 118.2万股 | $5,435.1万 | 114.3万股 | +3.9万股+3.44% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #255 | $6,299.9万 | 115.5万股 | $4,676.5万 | 98.3万股 | +17.2万股+17.50% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | 0.01% | #240 | $5,951.8万 | 109.1万股 | $7,835.3万 | 164.7万股 | -55.6万股-33.75% | 减仓 |
| NEA Management Company, LLC |
| 3.64% | 2.86% | #5 | $5,773.4万 | 105.9万股 | $5,035.6万 | 105.9万股 | 00.00% | 持仓不变 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #188 | $5,769.4万 | 105.8万股 | $4,944.2万 | 103.9万股 | +1.8万股+1.78% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #205 | $5,520.0万 | 101.2万股 | $6,410.3万 | 134.8万股 | -33.5万股-24.89% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.03% | <0.01% | #115 | $5,498.2万 | 100.8万股 | $678.8万 | 14.3万股 | +86.5万股+606.46% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | 0.01% | #295 | $4,799.2万 | 88.0万股 | $9,059.5万 | 139.8万股 | -51.8万股-37.05% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #220 | $4,707.3万 | 86.3万股 | $3,816.0万 | 80.2万股 | +6.1万股+7.59% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #342 | $3,538.1万 | 64.9万股 | $2,601.3万 | 54.7万股 | +10.2万股+18.63% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #196 | $3,109.0万 | 57.0万股 | $2,581.5万 | 54.3万股 | +2.7万股+5.04% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #357 | $2,456.9万 | 43.2万股 | $2,029.2万 | 45.8万股 | -2.6万股-5.67% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #185 | $2,398.3万 | 44.0万股 | $1,794.2万 | 37.7万股 | +6.3万股+16.58% | 加仓 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
| 1.33% | 1.45% | #10 | $2,083.4万 | 38.2万股 | $1,907.0万 | 40.1万股 | -1.9万股-4.71% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | 0.01% | #346 | $1,862.4万 | 34.1万股 | $3,939.3万 | 82.8万股 | -48.7万股-58.76% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #283 | $1,782.2万 | 32.7万股 | $1,481.2万 | 31.1万股 | +1.5万股+4.94% | 加仓 |
| PEAK6PEAK6 LLC |
| 0.03% | 0.05% | #105 | $1,668.5万 | 30.6万股 | $2,262.9万 | 47.6万股 | -17.0万股-35.69% | 减仓 |
| Logos Global Management LP |
| 0.7% | — | #16 | $1,636.2万 | 30.0万股 | $0 | 0股 | +30.0万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| 0.02% | 0.01% | #135 | $1,587.1万 | 29.1万股 | $826.2万 | 17.4万股 | +11.7万股+67.55% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| 0.12% | 0.07% | #52 | $1,516.0万 | 27.8万股 | $511.1万 | 10.7万股 | +17.1万股+158.71% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #290 | $1,503.5万 | 27.5万股 | $2,348.8万 | 49.4万股 | -21.9万股-44.28% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #366 | $1,485.5万 | 27.2万股 | $1,970.4万 | 41.4万股 | -14.2万股-34.24% | 减仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | <0.01% | #348 | $1,476.7万 | 27.1万股 | $1,552.0万 | 45.6万股 | -18.5万股-40.63% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #302 | $1,435.3万 | 26.3万股 | $1,335.3万 | 28.1万股 | -1.8万股-6.25% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #289 | $1,367.0万 | 25.1万股 | $1,364.1万 | 28.7万股 | -3.6万股-12.63% | 减仓 |
| Vestmark顾问方案Vestmark Advisory Solutions, Inc. |
| 0.12% | 0.14% | #51 | $1,321.3万 | 24.2万股 | $1,221.5万 | 25.7万股 | -1.5万股-5.65% | 减仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #268 | $1,265.3万 | 23.2万股 | $1,047.8万 | 22.0万股 | +1.2万股+5.32% | 加仓 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #259 | $1,179.8万 | 21.6万股 | $480.3万 | 10.1万股 | +11.5万股+114.24% | 加仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #291 | $1,107.6万 | 20.3万股 | $907.5万 | 19.1万股 | +1.2万股+6.46% | 加仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #353 | $943.8万 | 17.3万股 | $778.9万 | 16.4万股 | +9,326股+5.70% | 加仓 |
| Marex集团Marex Group plc |
| 0.04% | 0.04% | #99 | $930.4万 | 17.1万股 | $637.9万 | 13.4万股 | +3.6万股+27.21% | 加仓 |
| 瑞士央行Swiss National Bank |
| <0.01% | <0.01% | #237 | $922.8万 | 16.9万股 | $807.3万 | 17.0万股 | -500股-0.29% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.14% | 0.07% | #44 | $894.6万 | 16.4万股 | $501.3万 | 10.5万股 | +5.9万股+55.66% | 加仓 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | <0.01% | #324 | $893.4万 | 16.4万股 | $359.8万 | 7.6万股 | +8.8万股+116.57% | 加仓 |
