| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 5.44% | 5.48% | #2 | $10.86亿 | 4,291.3万股 | $9.55亿 | 4,289.7万股 | +1.6万股+0.04% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #111 | $5.70亿 | 2,251.5万股 | $4.80亿 | 2,155.1万股 | +96.4万股+4.47% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #121 | $2.30亿 | 907.6万股 | $1.85亿 | 833.3万股 | +74.3万股+8.92% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #98 | $2.24亿 | 883.8万股 | $1.93亿 | 867.2万股 | +16.7万股+1.92% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 1.54% | 1.58% | #6 | $1.81亿 | 714.5万股 | $1.59亿 | 714.5万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #174 | $1.46亿 | 576.4万股 | $1.26亿 | 566.1万股 | +10.2万股+1.81% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.02% | 0.01% | #84 | $9,348.3万 | 369.5万股 | $7,022.2万 | 315.5万股 | +54.0万股+17.11% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #151 | $8,497.7万 | 335.8万股 | $7,713.7万 | 346.5万股 | -10.7万股-3.08% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | <0.01% | #134 | $6,527.7万 | 258.0万股 | $3,467.7万 | 155.8万股 | +102.2万股+65.63% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.07% | 0.07% | #39 | $6,227.8万 | 246.2万股 | $5,799.4万 | 260.5万股 | -14.4万股-5.52% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.06% | 0.02% | #44 | $6,189.9万 | 244.7万股 | $2,115.4万 | 95.0万股 | +149.6万股+157.46% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #123 | $5,776.4万 | 228.3万股 | $1,466.2万 | 65.9万股 | +162.5万股+246.64% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.05% | 0.05% | #52 | $5,014.6万 | 198.3万股 | $4,473.6万 | 202.6万股 | -4.3万股-2.11% | 减仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.02% | 0.02% | #71 | $4,982.7万 | 196.9万股 | $3,493.7万 | 156.9万股 | +40.0万股+25.48% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.04% | <0.01% | #61 | $4,465.0万 | 176.5万股 | $169.6万 | 7.6万股 | +168.9万股+2,216.46% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.02% | 0.01% | #73 | $4,295.8万 | 169.8万股 | $1,624.6万 | 73.0万股 | +96.8万股+132.65% | 加仓 |
| BRAIDWELL LP |
| 1.54% | 1.84% | #7 | $4,165.4万 | 164.6万股 | $5,500.9万 | 247.1万股 | -82.5万股-33.38% | 减仓 |
| 挪威央行投资管理NORGES BANK |
| <0.01% | <0.01% | #155 | $4,107.0万 | 162.3万股 | $2,359.6万 | 142.1万股 | +20.3万股+14.27% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.79% | 0.82% | #9 | $3,638.6万 | 143.8万股 | $3,201.4万 | 143.8万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #158 | $3,459.6万 | 136.7万股 | $2,832.8万 | 127.3万股 | +9.5万股+7.45% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | 0.01% | #113 | $3,410.9万 | 134.8万股 | $2,308.3万 | 103.7万股 | +31.1万股+30.01% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.05% | 0.05% | #50 | $3,352.6万 | 132.5万股 | $2,964.6万 | 133.2万股 | -6,679股-0.50% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #192 | $3,290.0万 | 130.0万股 | $3,458.7万 | 155.4万股 | -25.3万股-16.31% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.06% | #54 | $3,245.0万 | 128.3万股 | $3,838.1万 | 172.4万股 | -44.2万股-25.61% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #156 | $3,052.0万 | 120.6万股 | $2,612.3万 | 117.4万股 | +3.3万股+2.79% | 加仓 |
| Allspring环球投资Allspring Global Investments Holdings, LLC |
| 0.04% | 0.04% | #55 | $2,854.1万 | 113.3万股 | $2,131.2万 | 95.5万股 | +17.8万股+18.61% | 加仓 |
| 洛克菲勒资本管理Rockefeller Capital Management L.P. |
| 0.04% | 0.04% | #60 | $2,569.0万 | 101.5万股 | $2,286.9万 | 102.7万股 | -1.2万股-1.16% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #219 | $2,395.0万 | 94.7万股 | $2,536.1万 | 118.8万股 | -24.2万股-20.34% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.01% | #83 | $2,345.3万 | 92.7万股 | $1,725.4万 | 77.5万股 | +15.2万股+19.59% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | <0.01% | #141 | $2,308.3万 | 91.2万股 | $1,949.4万 | 87.6万股 | +3.7万股+4.19% | 加仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #120 | $2,164.3万 | 85.5万股 | $2,270.1万 | 102.0万股 | -16.4万股-16.12% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #209 | $2,050.5万 | 81.0万股 | $1,862.1万 | 83.7万股 | -2.6万股-3.11% | 减仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.01% | 0.01% | #102 | $1,996.7万 | 78.9万股 | $1,710.1万 | 76.8万股 | +2.1万股+2.73% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #172 | $1,924.4万 | 76.1万股 | $1,639.6万 | 73.7万股 | +2.4万股+3.27% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.06% | 0.06% | #47 | $1,798.6万 | 71.1万股 | $1,532.9万 | 68.9万股 | +2.2万股+3.23% | 加仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.01% | 0.01% | #138 | $1,769.1万 | 69.9万股 | $1,631.4万 | 73.3万股 | -3.4万股-4.59% | 减仓 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.05% | 0.12% | #48 | $1,641.0万 | 64.9万股 | $2,842.9万 | 127.7万股 | -62.9万股-49.21% | 减仓 |
| 安联资产管理Allianz Asset Management GmbH |
| 0.01% | 0.02% | #87 | $1,573.0万 | 70.7万股 | $1,573.0万 | 70.7万股 | 00.00% | 持仓不变 |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.76% | 0.77% | #10 | $1,565.8万 | 61.9万股 | $1,374.5万 | 61.7万股 | +1,398股+0.23% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #175 | $1,534.8万 | 60.7万股 | $1,390.3万 | 62.4万股 | -1.8万股-2.84% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.01% | #143 | $1,492.5万 | 59.0万股 | $1,570.4万 | 70.5万股 | -11.6万股-16.38% | 减仓 |
| 宏利人寿MANUFACTURERS LIFE INSURANCE COMPANY, THE |
| 0.01% | 0.01% | #92 | $1,477.1万 | 58.4万股 | $1,272.8万 | 57.2万股 | +1.2万股+2.11% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | 0.01% | #148 | $1,322.6万 | 52.3万股 | $1,175.1万 | 52.8万股 | -5,164股-0.98% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.02% | <0.01% | #81 | $1,290.3万 | 51.0万股 | $22.3万 | 1.0万股 | +50.0万股+5,000.00% | 加仓 |
| 格伦米德信托GLENMEDE TRUST CO NA |
| 0.05% | 0.04% | #49 | $1,236.0万 | 48.9万股 | $903.5万 | 40.6万股 | +8.3万股+20.36% | 加仓 |
| 哈德逊湾资本管理Hudson Bay Capital Management LP |
| 0.03% | 0.03% | #63 | $1,176.5万 | 46.5万股 | $991.7万 | 44.6万股 | +1.9万股+4.38% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #213 | $1,163.9万 | 46.0万股 | $998.5万 | 44.9万股 | +1.2万股+2.56% | 加仓 |
| 木星资产管理JUPITER ASSET MANAGEMENT LTD |
| 0.06% | 0.06% | #43 | $1,159.9万 | 45.8万股 | $1,093.2万 | 49.1万股 | -3.3万股-6.64% | 减仓 |
| 加拿大公共部门养老金投资委员会(PSP)PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.03% | 0.03% | #65 | $1,101.5万 | 43.5万股 | $997.1万 | 44.8万股 | -1.3万股-2.80% | 减仓 |
| 麦肯齐金融MACKENZIE FINANCIAL CORP |
| 0.01% | <0.01% | #96 | $1,064.7万 | 42.1万股 | $225.6万 | 10.1万股 | +31.9万股+315.27% | 加仓 |
