| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 12.57% | 15% | #1 | $25.08亿 | 880.2万股 | $26.13亿 | 879.9万股 | +2,514股+0.03% | 加仓 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.84% | 1.16% | #9 | $14.27亿 | 500.8万股 | $14.77亿 | 497.5万股 | +3.3万股+0.66% | 加仓 |
| 资本国际投资者Capital International Investors |
| 0.25% | 0.29% | #25 | $12.01亿 | 421.0万股 | $12.31亿 | 415.9万股 | +5.1万股+1.24% | 加仓 |
| 富达投资FMR LLC |
| 0.03% | 0.06% | #76 | $7.06亿 | 247.9万股 | $10.97亿 | 369.4万股 | -121.5万股-32.90% | 减仓 |
| 资本世界投资者Capital World Investors |
| 0.08% | 0.07% | #46 | $6.41亿 | 225.0万股 | $4.82亿 | 162.3万股 | +62.7万股+38.63% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.05% | 0.05% | #61 | $4.12亿 | 144.6万股 | $3.13亿 | 105.2万股 | +39.3万股+37.37% | 加仓 |
| 淡马锡控股Temasek Holdings (Private) Ltd |
| 0.65% | 0.84% | #14 | $2.41亿 | 84.6万股 | $2.56亿 | 86.3万股 | -1.7万股-1.96% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.02% | #85 | $2.16亿 | 75.9万股 | $1.60亿 | 54.0万股 | +21.9万股+40.57% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #155 | $1.98亿 | 69.5万股 | $1.95亿 | 65.8万股 | +3.7万股+5.65% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.05% | 0.03% | #56 | $1.62亿 | 56.8万股 | $6,083.3万 | 20.5万股 | +36.3万股+177.44% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | 0.01% | #118 | $1.42亿 | 49.7万股 | $1.20亿 | 35.3万股 | +14.4万股+40.80% | 加仓 |
| Siren, L.L.C. |
| 2.68% | 3.83% | #5 | $1.33亿 | 46.5万股 | $1.38亿 | 46.5万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #114 | $1.25亿 | 43.9万股 | $1.20亿 | 40.5万股 | +3.4万股+8.40% | 加仓 |
| 贝尔德金融集团Baird Financial Group, Inc. |
| 0.14% | 0.16% | #32 | $1.05亿 | 36.9万股 | $1.04亿 | 35.0万股 | +1.9万股+5.53% | 加仓 |
| 英仕曼集团Man Group plc |
| 0.14% | 0.13% | #33 | $8,761.8万 | 30.7万股 | $7,184.4万 | 24.2万股 | +6.6万股+27.09% | 加仓 |
| 资本国际(加州)Capital International, Inc./CA/ |
| 0.61% | 0.69% | #16 | $8,705.2万 | 30.5万股 | $8,975.7万 | 30.2万股 | +3,234股+1.07% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.37% | 0.3% | #19 | $8,248.6万 | 29.0万股 | $5,993.2万 | 19.7万股 | +9.2万股+46.88% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.01% | #53 | $8,165.9万 | 28.7万股 | $996.1万 | 3.4万股 | +25.3万股+754.28% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.02% | #108 | $7,369.0万 | 25.9万股 | $1.23亿 | 41.5万股 | -15.7万股-37.74% | 减仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| 0.03% | 0.02% | #75 | $7,117.4万 | 25.0万股 | $3,284.1万 | 11.1万股 | +13.9万股+125.85% | 加仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.04% | 0.05% | #65 | $7,005.2万 | 24.6万股 | $7,169.6万 | 24.1万股 | +4,397股+1.82% | 加仓 |
| M&G(英国)M&G Plc |
| 0.32% | 0.21% | #21 | $6,368.2万 | 22.3万股 | $4,103.4万 | 13.8万股 | +8.5万股+61.73% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | 0.02% | #98 | $5,729.6万 | 20.1万股 | $5,833.4万 | 19.6万股 | +4,633股+2.36% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #153 | $5,463.6万 | 18.8万股 | $2,202.7万 | 7.8万股 | +11.1万股+142.98% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.03% | 0.03% | #79 | $5,287.4万 | 18.6万股 | $5,474.8万 | 18.4万股 | +1,188股+0.64% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.04% | 0.05% | #67 | $5,072.1万 | 17.8万股 | $5,127.0万 | 17.3万股 | +5,344股+3.10% | 加仓 |
| 资本国际Capital International Sarl |
| 0.71% | 0.85% | #12 | $5,002.4万 | 17.6万股 | $5,163.7万 | 17.4万股 | +1,663股+0.96% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #137 | $4,494.0万 | 15.8万股 | $2,871.0万 | 9.7万股 | +6.1万股+63.12% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #116 | $3,762.5万 | 13.2万股 | $5,988.1万 | 20.2万股 | -7.0万股-34.52% | 减仓 |
| 瑞典Länsförsäkringar基金Lansforsakringar Fondforvaltning AB (publ) |
| 0.16% | — | #30 | $3,515.5万 | 12.3万股 | $0 | 0股 | +12.3万股 | 新买入 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.05% | 0.07% | #58 | $3,287.8万 | 11.5万股 | $4,074.9万 | 13.7万股 | -2.2万股-15.92% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.04% | 0.03% | #68 | $2,906.1万 | 10.2万股 | $1,943.8万 | 6.5万股 | +3.7万股+55.80% | 加仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.02% | 0.03% | #89 | $2,869.6万 | 10.1万股 | $4,587.1万 | 15.4万股 | -5.4万股-34.81% | 减仓 |
| 拉扎德资产管理LAZARD ASSET MANAGEMENT LLC |
| 0.04% | 0.03% | #70 | $2,574.6万 | 9.0万股 | $1,868.4万 | 6.3万股 | +2.7万股+43.60% | 加仓 |
| Patient Square Capital LP |
| 3.97% | 4.24% | #2 | $2,565.3万 | 9.0万股 | $2,391.9万 | 8.1万股 | +9,478股+11.77% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.02% | — | #84 | $2,316.2万 | 8.1万股 | $0 | 0股 | +8.1万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| 0.02% | 0.03% | #81 | $2,238.8万 | 7.9万股 | $2,201.3万 | 7.4万股 | +4,437股+5.99% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #176 | $2,224.5万 | 7.8万股 | $3,552.0万 | 12.0万股 | -4.2万股-34.74% | 减仓 |
| CAPITAL INTERNATIONAL LTD /CA/ |
| 0.72% | 0.84% | #11 | $2,198.9万 | 7.7万股 | $2,272.3万 | 7.7万股 | +646股+0.84% | 加仓 |
| Life Cycle投资合伙人Life Cycle Investment Partners Ltd |
| 0.1% | — | #41 | $2,081.6万 | 7.3万股 | $0 | 0股 | +7.3万股 | 新买入 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #152 | $2,048.0万 | 7.2万股 | $2,090.5万 | 7.0万股 | +1,470股+2.09% | 加仓 |
| 荷兰银行投资方案ABN AMRO INVESTMENT SOLUTIONS |
| 0.16% | 0.18% | #29 | $1,867.2万 | 6.6万股 | $1,412.5万 | 4.8万股 | +1.8万股+37.76% | 加仓 |
| Envestnet资产管理ENVESTNET ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #135 | $1,724.8万 | 6.1万股 | $1,770.3万 | 6.0万股 | +914股+1.53% | 加仓 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | <0.01% | #143 | $1,707.3万 | 6.0万股 | $1,777.6万 | 6.0万股 | +78股+0.13% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.05% | 0.06% | #57 | $1,705.0万 | 6.0万股 | $1,702.2万 | 5.7万股 | +2,511股+4.38% | 加仓 |
| 范埃克联合公司VAN ECK ASSOCIATES CORP |
| 0.01% | 0.02% | #106 | $1,567.4万 | 5.5万股 | $3,216.3万 | 10.8万股 | -5.3万股-49.22% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.05% | — | #60 | $1,540.7万 | 5.4万股 | $0 | 0股 | +5.4万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #160 | $1,512.8万 | 5.3万股 | $1,546.1万 | 5.2万股 | +1,023股+1.96% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #194 | $1,394.7万 | 4.9万股 | $3,253.4万 | 11.0万股 | -6.1万股-55.33% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #161 | $1,333.5万 | 4.7万股 | $1,685.9万 | 5.7万股 | -1.0万股-17.84% | 减仓 |
