| 贝莱德BlackRock, Inc. |
| 0.01% | <0.01% | #148 | $3.56亿 | 1,065.4万股 | $1.53亿 | 730.0万股 | +335.5万股+45.96% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 2.22% | 0.76% | #10 | $2.60亿 | 779.7万股 | $7,644.2万 | 364.9万股 | +414.8万股+113.68% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #120 | $2.27亿 | 679.0万股 | $1.13亿 | 538.6万股 | +140.4万股+26.07% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| 0.07% | 0.04% | #58 | $2.14亿 | 656.1万股 | $9,591.0万 | 457.8万股 | +198.3万股+43.31% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | <0.01% | #138 | $2.06亿 | 615.9万股 | $1.05亿 | 502.1万股 | +113.7万股+22.65% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #181 | $1.43亿 | 429.6万股 | $8,777.7万 | 419.0万股 | +10.7万股+2.55% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.09% | 0.04% | #54 | $1.21亿 | 362.1万股 | $4,621.2万 | 220.6万股 | +141.5万股+64.17% | 加仓 |
| Sands资本管理SANDS CAPITAL MANAGEMENT, LLC |
| 0.39% | 0.26% | #29 | $1.05亿 | 315.8万股 | $6,734.4万 | 321.5万股 | -5.6万股-1.75% | 减仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| 0.35% | 0.13% | #32 | $9,815.7万 | 294.0万股 | $2,998.1万 | 143.1万股 | +150.9万股+105.42% | 加仓 |
| Frontier资本管理FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.89% | 0.47% | #19 | $9,509.3万 | 284.8万股 | $4,590.5万 | 219.1万股 | +65.7万股+29.97% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #153 | $8,612.4万 | 257.9万股 | $3,875.4万 | 184.9万股 | +72.9万股+39.44% | 加仓 |
| Sofinnova Investments, Inc. |
| 3.83% | 2.78% | #4 | $7,404.2万 | 221.8万股 | $7,323.9万 | 349.6万股 | -127.8万股-36.57% | 减仓 |
| Bellevue 集团Bellevue Group AG |
| 1.39% | 1.19% | #15 | $6,620.5万 | 198.3万股 | $4,986.1万 | 238.0万股 | -39.7万股-16.69% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.03% | 0.02% | #83 | $5,777.1万 | 173.0万股 | $2,641.8万 | 126.1万股 | +46.9万股+37.21% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.07% | 0.02% | #59 | $5,275.6万 | 158.0万股 | $1,005.6万 | 48.0万股 | +110.0万股+229.17% | 加仓 |
| GW&K Investment Management, LLC |
| 0.39% | 0.3% | #30 | $4,945.7万 | 148.1万股 | $3,384.4万 | 161.5万股 | -13.4万股-8.31% | 减仓 |
| MPM BioImpact LLC |
| 2.89% | — | #8 | $4,735.4万 | 141.8万股 | $0 | 0股 | +141.8万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #154 | $4,529.4万 | 135.7万股 | $1,684.7万 | 80.4万股 | +55.2万股+68.70% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #197 | $4,423.5万 | 132.5万股 | $2,737.8万 | 91.0万股 | +41.5万股+45.55% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.2% | 0.09% | #41 | $4,209.5万 | 126.1万股 | $1,550.3万 | 74.0万股 | +52.1万股+70.36% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #132 | $4,175.3万 | 125.0万股 | $5,532.5万 | 264.1万股 | -139.0万股-52.65% | 减仓 |
| Voloridge投资管理VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.18% | 0.12% | #42 | $4,145.6万 | 124.2万股 | $2,989.2万 | 142.7万股 | -18.5万股-12.99% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #194 | $3,834.7万 | 114.8万股 | $2,192.5万 | 104.7万股 | +10.2万股+9.74% | 加仓 |
| 康得利安资管Candriam S.C.A. |
| 0.15% | 0.09% | #45 | $3,341.9万 | 100.2万股 | $1,838.7万 | 79.9万股 | +20.2万股+25.33% | 加仓 |
| Rock Springs Capital Management LP |
| 1.58% | 1.5% | #14 | $3,231.7万 | 96.8万股 | $2,553.3万 | 121.9万股 | -25.1万股-20.59% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #193 | $3,225.0万 | 96.6万股 | $2,379.5万 | 113.6万股 | -17.0万股-14.96% | 减仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.2% | <0.01% | #39 | $3,104.0万 | 93.0万股 | $32.4万 | 1.5万股 | +91.4万股+5,902.23% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #169 | $3,072.9万 | 92.0万股 | $1,122.0万 | 53.6万股 | +38.5万股+71.84% | 加仓 |
| Eagle Health Investments LP |
| 4.89% | 3.24% | #3 | $2,952.1万 | 88.4万股 | $1,852.2万 | 88.4万股 | 00.00% | 持仓不变 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.03% | 0.02% | #84 | $2,945.7万 | 88.2万股 | $1,916.4万 | 91.5万股 | -3.3万股-3.56% | 减仓 |
| 罗素投资集团Russell Investments Group, Ltd. |
| 0.02% | 0.01% | #95 | $2,618.1万 | 78.4万股 | $844.2万 | 40.3万股 | +38.1万股+94.59% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #126 | $2,540.4万 | 76.1万股 | $3,712.7万 | 177.2万股 | -101.1万股-57.07% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #172 | $2,537.8万 | 76.0万股 | $1,170.0万 | 55.8万股 | +20.2万股+36.09% | 加仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #145 | $2,317.1万 | 69.4万股 | $1,387.0万 | 66.2万股 | +3.2万股+4.82% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.02% | 0.01% | #91 | $2,316.0万 | 75.4万股 | $1,167.1万 | 60.4万股 | +15.0万股+24.87% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #152 | $2,241.8万 | 67.1万股 | $1,274.2万 | 60.8万股 | +6.3万股+10.39% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #188 | $2,196.1万 | 65.8万股 | $1,744.6万 | 83.3万股 | -17.5万股-21.02% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #205 | $2,121.4万 | 63.5万股 | $776.4万 | 37.1万股 | +26.5万股+71.44% | 加仓 |
| GREAT POINT PARTNERS LLC |
| 3.79% | — | #6 | $2,003.4万 | 60.0万股 | $0 | 0股 | +60.0万股 | 新买入 |
| Palo Alto Investors LP |
| 2.91% | 1.91% | #7 | $1,991.7万 | 59.6万股 | $1,249.7万 | 59.6万股 | 00.00% | 持仓不变 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 2.57% | 2.69% | #9 | $1,965.0万 | 58.8万股 | $1,695.6万 | 80.9万股 | -22.1万股-27.29% | 减仓 |
| 英国法通集团Legal & General Group Plc |
| <0.01% | <0.01% | #161 | $1,958.4万 | 58.7万股 | $1,236.2万 | 59.0万股 | -3,774股-0.64% | 减仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.06% | — | #65 | $1,957.4万 | 58.6万股 | $0 | 0股 | +58.6万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #234 | $1,926.1万 | 57.7万股 | $601.9万 | 28.7万股 | +29.0万股+100.77% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| 0.11% | 0.06% | #48 | $1,857.8万 | 55.6万股 | $815.9万 | 38.9万股 | +16.7万股+42.86% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.01% | <0.01% | #128 | $1,663.4万 | 49.8万股 | $1,028.2万 | 49.1万股 | +7,384股+1.50% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #191 | $1,571.7万 | 47.1万股 | $714.7万 | 34.1万股 | +13.0万股+37.98% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #233 | $1,526.8万 | 49.3万股 | $474.6万 | 24.6万股 | +24.7万股+100.52% | 加仓 |
| 多伦多道明银行TORONTO DOMINION BANK |
| 0.02% | <0.01% | #102 | $1,385.7万 | 41.5万股 | $3,394 | 162股 | +41.5万股+256,072.84% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.02% | 0.02% | #97 | $1,381.3万 | 41.4万股 | $1,176.8万 | 56.2万股 | -14.8万股-26.35% | 减仓 |
