| 富达投资FMR LLC |
| 0.06% | 0.05% | #71 | $14.16亿 | 1,234.9万股 | $9.74亿 | 1,170.0万股 | +64.9万股+5.55% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 4.97% | 4.14% | #6 | $9.93亿 | 865.7万股 | $7.21亿 | 865.7万股 | 00.00% | 持仓不变 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 7.7% | 6.12% | #4 | $8.57亿 | 747.5万股 | $6.23亿 | 747.5万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.08% | 0.06% | #66 | $8.16亿 | 711.3万股 | $5.05亿 | 606.1万股 | +105.2万股+17.36% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.47% | 0.31% | #32 | $7.18亿 | 625.7万股 | $4.55亿 | 546.5万股 | +79.2万股+14.50% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #125 | $6.35亿 | 553.8万股 | $4.22亿 | 506.1万股 | +47.7万股+9.43% | 加仓 |
| BVF INC/IL |
| 11.35% | 14.6% | #3 | $4.44亿 | 387.2万股 | $4.58亿 | 550.3万股 | -163.1万股-29.63% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.06% | #68 | $4.21亿 | 367.5万股 | $3.24亿 | 389.0万股 | -21.5万股-5.52% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.01% | #107 | $3.43亿 | 299.2万股 | $2.39亿 | 287.4万股 | +11.8万股+4.11% | 加仓 |
| Siren, L.L.C. |
| 6.81% | 7.36% | #5 | $3.37亿 | 293.6万股 | $2.65亿 | 318.7万股 | -25.1万股-7.88% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #142 | $3.36亿 | 293.2万股 | $2.40亿 | 288.0万股 | +5.2万股+1.81% | 加仓 |
| Atlas Venture Life Science Advisors, LLC |
| 37.05% | 48.26% | #1 | $3.27亿 | 284.8万股 | $3.81亿 | 457.8万股 | -173.0万股-37.80% | 减仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #126 | $3.14亿 | 273.7万股 | $1.99亿 | 239.0万股 | +34.7万股+14.54% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #122 | $2.08亿 | 181.6万股 | $1.37亿 | 164.5万股 | +17.1万股+10.39% | 加仓 |
| 资本研究全球投资者Capital Research Global Investors |
| 0.02% | 0.02% | #95 | $1.59亿 | 138.9万股 | $1.39亿 | 167.3万股 | -28.4万股-17.00% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #120 | $1.36亿 | 118.7万股 | $7,399.6万 | 88.8万股 | +29.9万股+33.65% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #111 | $1.16亿 | 100.8万股 | $8,527.7万 | 102.4万股 | -1.6万股-1.57% | 减仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.61% | 0.64% | #29 | $1.05亿 | 91.9万股 | $8,692.0万 | 104.4万股 | -12.4万股-11.92% | 减仓 |
| Merck & Co., Inc. |
| 16.82% | 18.4% | #2 | $8,854.4万 | 77.2万股 | $6,431.4万 | 77.2万股 | 00.00% | 持仓不变 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | <0.01% | #130 | $8,683.3万 | 75.7万股 | $136.0万 | 5.0万股 | +70.8万股+1,423.73% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.12% | 0.07% | #55 | $8,593.3万 | 74.9万股 | $4,470.0万 | 53.7万股 | +21.3万股+39.64% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.02% | 0.01% | #106 | $8,542.2万 | 74.5万股 | $4,935.9万 | 59.3万股 | +15.2万股+25.68% | 加仓 |
| Frontier资本管理FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.79% | 0.65% | #24 | $8,495.5万 | 74.1万股 | $6,328.8万 | 76.0万股 | -1.9万股-2.50% | 减仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.02% | 0.02% | #109 | $8,449.6万 | 73.7万股 | $7,295.1万 | 87.6万股 | -13.9万股-15.87% | 减仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.03% | 0.02% | #88 | $8,175.1万 | 98.2万股 | $6,909.8万 | 88.8万股 | +9.3万股+10.53% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.16% | 0.17% | #48 | $7,299.7万 | 63.7万股 | $6,969.4万 | 83.7万股 | -20.0万股-23.92% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #138 | $6,672.7万 | 58.2万股 | $4,118.2万 | 49.4万股 | +8.7万股+17.69% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #137 | $6,074.4万 | 53.0万股 | $4,125.0万 | 49.5万股 | +3.4万股+6.96% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #118 | $5,906.1万 | 51.5万股 | $3,013.2万 | 36.2万股 | +15.3万股+42.37% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 0.77% | 0.86% | #25 | $5,781.1万 | 50.4万股 | $5,221.3万 | 62.7万股 | -12.3万股-19.57% | 减仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.03% | 0.03% | #81 | $5,767.6万 | 50.3万股 | $4,239.5万 | 50.9万股 | -6,021股-1.18% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.18% | 0.06% | #45 | $5,743.5万 | 50.1万股 | $1,695.7万 | 20.4万股 | +29.7万股+146.02% | 加仓 |
| Rock Springs Capital Management LP |
| 2.54% | 2.44% | #14 | $5,196.3万 | 45.3万股 | $4,138.4万 | 49.7万股 | -4.4万股-8.80% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #121 | $5,157.1万 | 45.0万股 | $3,559.7万 | 42.7万股 | +2.2万股+5.23% | 加仓 |
| Boxer Capital Management, LLC |
| 3.71% | 3.6% | #7 | $4,920.5万 | 42.9万股 | $2,741.1万 | 32.9万股 | +10.0万股+30.39% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.04% | 0.04% | #80 | $4,498.4万 | 39.6万股 | $3,876.0万 | 46.9万股 | -7.3万股-15.61% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #175 | $4,337.8万 | 37.8万股 | $2,410.5万 | 28.9万股 | +8.9万股+30.71% | 加仓 |
| BRAIDWELL LP |
| 1.6% | 0.94% | #17 | $4,336.4万 | 37.8万股 | $2,811.5万 | 33.8万股 | +4.1万股+12.03% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #96 | $4,310.1万 | 37.6万股 | $2,381.0万 | 28.6万股 | +9.0万股+31.48% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.03% | 0.02% | #85 | $4,258.5万 | 37.1万股 | $2,136.4万 | 25.7万股 | +11.5万股+44.78% | 加仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.03% | — | #82 | $3,981.6万 | 34.7万股 | $0 | 0股 | +34.7万股 | 新买入 |
| Octagon Capital Advisors LP |
| 3.2% | 3.92% | #8 | $3,554.8万 | 31.0万股 | $3,539.8万 | 42.5万股 | -11.5万股-27.06% | 减仓 |
| Nextech Invest Ltd. |
| 1.52% | 1.63% | #18 | $3,198.1万 | 27.9万股 | $2,322.9万 | 27.9万股 | 00.00% | 持仓不变 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.08% | 0.08% | #65 | $3,170.1万 | 27.6万股 | $2,854.3万 | 34.3万股 | -6.6万股-19.33% | 减仓 |
| 道明资产管理TD ASSET MANAGEMENT INC |
| 0.03% | 0.02% | #89 | $3,129.3万 | 27.3万股 | $2,391.3万 | 28.7万股 | -1.4万股-4.95% | 减仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | 0.02% | #91 | $3,095.1万 | 27.0万股 | $1,655.9万 | 19.9万股 | +7.1万股+35.77% | 加仓 |
| Commodore Capital LP |
| 1.71% | 3.61% | #16 | $2,866.8万 | 25.0万股 | $6,246.8万 | 75.0万股 | -50.0万股-66.67% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.23% | 0.2% | #42 | $2,752.1万 | 24.0万股 | $1,999.0万 | 24.0万股 | 00.00% | 持仓不变 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #129 | $2,680.0万 | 23.4万股 | $1,740.8万 | 20.9万股 | +2.5万股+11.82% | 加仓 |
| 吉尔德·加尼翁·豪GILDER GAGNON HOWE & CO LLC |
| 0.27% | 0.24% | #38 | $2,626.6万 | 22.9万股 | $1,960.9万 | 23.5万股 | -6,380股-2.71% | 减仓 |
