| 富达投资FMR LLC |
| 0.04% | 0.05% | #98 | $9.94亿 | 2,568.1万股 | $8.90亿 | 2,312.3万股 | +255.8万股+11.06% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #143 | $6.72亿 | 1,735.3万股 | $6.18亿 | 1,604.5万股 | +130.8万股+8.15% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #135 | $3.12亿 | 807.2万股 | $2.82亿 | 733.3万股 | +73.9万股+10.08% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #169 | $2.87亿 | 741.2万股 | $2.65亿 | 689.5万股 | +51.7万股+7.50% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #151 | $2.70亿 | 696.5万股 | $2.18亿 | 566.4万股 | +130.1万股+22.98% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.1% | — | #76 | $2.56亿 | 662.5万股 | $0 | 0股 | +662.5万股 | 新买入 |
| Fairmount Funds Management LLC |
| 14.08% | 15.3% | #1 | $2.13亿 | 550.3万股 | $2.12亿 | 550.3万股 | 00.00% | 持仓不变 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 2.02% | 4.11% | #19 | $1.94亿 | 500.6万股 | $3.48亿 | 904.4万股 | -403.8万股-44.65% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 4.52% | 5.45% | #10 | $1.88亿 | 485.4万股 | $1.90亿 | 494.7万股 | -9.2万股-1.87% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #119 | $1.80亿 | 465.3万股 | $1.24亿 | 321.3万股 | +144.0万股+44.82% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #148 | $1.75亿 | 450.9万股 | $1.42亿 | 370.0万股 | +80.9万股+21.88% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.03% | #110 | $1.68亿 | 434.4万股 | $1.38亿 | 357.9万股 | +76.5万股+21.39% | 加仓 |
| Kynam Capital Management, LP |
| 7.84% | 9.59% | #6 | $1.42亿 | 366.7万股 | $1.55亿 | 403.7万股 | -37.0万股-9.17% | 减仓 |
| LORD, ABBETT & CO. LLC |
| 0.38% | 0.4% | #48 | $1.33亿 | 343.1万股 | $1.22亿 | 318.1万股 | +25.0万股+7.85% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.3% | — | #55 | $1.25亿 | 323.3万股 | $0 | 0股 | +323.3万股 | 新买入 |
| Commodore Capital LP |
| 7.03% | 6.43% | #7 | $1.18亿 | 305.0万股 | $1.11亿 | 288.8万股 | +16.2万股+5.61% | 加仓 |
| 景顺Invesco Ltd. |
| 0.01% | 0.01% | #152 | $1.01亿 | 260.9万股 | $9,351.6万 | 243.0万股 | +18.0万股+7.39% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.31% | 0.22% | #52 | $1.01亿 | 260.3万股 | $5,810.3万 | 151.0万股 | +109.4万股+72.45% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.09% | 0.07% | #81 | $9,263.4万 | 239.4万股 | $6,882.6万 | 179.9万股 | +59.5万股+33.06% | 加仓 |
| Octagon Capital Advisors LP |
| 8.17% | 10.01% | #5 | $9,094.5万 | 235.0万股 | $9,045.2万 | 235.0万股 | 00.00% | 持仓不变 |
| RTW投资RTW INVESTMENTS, LP |
| 0.76% | 2.09% | #39 | $8,935.9万 | 230.9万股 | $2.10亿 | 545.9万股 | -315.0万股-57.70% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.02% | #155 | $8,857.0万 | 228.9万股 | $1.71亿 | 443.4万股 | -214.5万股-48.39% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.36% | 0.23% | #49 | $8,074.2万 | 208.8万股 | $4,605.3万 | 129.6万股 | +79.2万股+61.08% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 1.13% | 0.63% | #31 | $7,740.0万 | 200.0万股 | $3,849.0万 | 100.0万股 | +100.0万股+100.00% | 加仓 |
| Siren, L.L.C. |
| 1.46% | 1.82% | #27 | $7,195.4万 | 185.9万股 | $6,579.0万 | 170.9万股 | +15.0万股+8.78% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.23% | 0.25% | #30 | $6,506.6万 | 168.1万股 | $1,239.8万 | 32.2万股 | +135.9万股+421.98% | 加仓 |
| Venrock Adviser, LLC |
| 1.93% | 2.87% | #20 | $6,355.2万 | 164.2万股 | $7,698.0万 | 200.0万股 | -35.8万股-17.89% | 减仓 |
| EMERALD ADVISERS, LLC |
| 1.46% | 1.93% | #26 | $6,204.8万 | 160.3万股 | $6,112.7万 | 158.8万股 | +1.5万股+0.96% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #161 | $6,028.8万 | 155.8万股 | $4,794.9万 | 124.6万股 | +31.2万股+25.05% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #156 | $5,608.8万 | 144.9万股 | $4,781.7万 | 124.2万股 | +20.7万股+16.66% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.07% | 0.02% | #87 | $5,579.6万 | 144.2万股 | $1,138.0万 | 29.6万股 | +114.6万股+387.66% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #198 | $5,571.4万 | 144.0万股 | $4,017.6万 | 104.4万股 | +39.6万股+37.92% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #112 | $5,545.6万 | 143.3万股 | $3,427.8万 | 89.1万股 | +54.2万股+60.90% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 5.15% | 5.16% | #8 | $4,956.3万 | 128.1万股 | $5,058.3万 | 131.4万股 | -3.3万股-2.55% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #142 | $4,696.3万 | 121.4万股 | $4,072.6万 | 105.8万股 | +15.5万股+14.69% | 加仓 |
| Elmind Capital, LP |
| 11.38% | 12.79% | #2 | $4,530.8万 | 117.1万股 | $4,506.2万 | 117.1万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| 0.01% | <0.01% | #175 | $4,343.1万 | 112.2万股 | $1,121.9万 | 29.1万股 | +83.1万股+285.01% | 加仓 |
| 弗雷德·阿尔杰管理FRED ALGER MANAGEMENT, LLC |
| 0.14% | 0.21% | #72 | $4,151.9万 | 107.3万股 | $4,771.6万 | 124.0万股 | -16.7万股-13.46% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | 0.01% | #185 | $4,151.3万 | 107.3万股 | $7,341.7万 | 190.7万股 | -83.5万股-43.76% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #204 | $4,139.2万 | 107.0万股 | $3,094.1万 | 80.4万股 | +26.6万股+33.05% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.05% | 0.04% | #95 | $4,082.2万 | 105.5万股 | $3,297.0万 | 85.7万股 | +19.8万股+23.14% | 加仓 |
| Sofinnova Investments, Inc. |
| 2.07% | 3.09% | #17 | $4,006.0万 | 103.5万股 | $8,135.1万 | 211.4万股 | -107.8万股-51.02% | 减仓 |
| EMERALD MUTUAL FUND ADVISERS 信托EMERALD MUTUAL FUND ADVISERS TRUST |
| 1.4% | 1.92% | #28 | $3,991.4万 | 103.1万股 | $3,960.0万 | 102.9万股 | +2,546股+0.25% | 加仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #136 | $3,955.8万 | 102.2万股 | $1,730.1万 | 44.9万股 | +57.3万股+127.41% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.05% | 0.04% | #94 | $3,855.2万 | 99.6万股 | $2,718.4万 | 70.6万股 | +29.0万股+41.05% | 加仓 |
| Voya投资管理VOYA INVESTMENT MANAGEMENT LLC |
| 0.03% | 0.03% | #107 | $3,687.2万 | 95.3万股 | $2,556.3万 | 66.4万股 | +28.9万股+43.46% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #225 | $3,644.5万 | 94.2万股 | $1,849.8万 | 128.8万股 | -34.6万股-26.89% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.02% | 0.04% | #122 | $3,570.0万 | 92.2万股 | $7,191.4万 | 186.8万股 | -94.6万股-50.63% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #137 | $3,512.8万 | 90.8万股 | $4,589.6万 | 119.2万股 | -28.5万股-23.88% | 减仓 |
| Logos Global Management LP |
| 1.5% | — | #24 | $3,483.0万 | 90.0万股 | $0 | 0股 | +90.0万股 | 新买入 |
