| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 22.22% | 20.85% | #1 | $21.30亿 | 1,724.8万股 | $17.67亿 | 1,724.8万股 | 00.00% | 持仓不变 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 13.7% | 11.15% | #3 | $7.32亿 | 592.4万股 | $5.45亿 | 532.4万股 | +60.0万股+11.27% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #126 | $6.90亿 | 558.6万股 | $4.94亿 | 482.5万股 | +76.1万股+15.77% | 加仓 |
| HBK投资HBK INVESTMENTS L P |
| 4.2% | — | #13 | $4.30亿 | 348.3万股 | $0 | 0股 | +348.3万股 | 新买入 |
| FIL(富达国际)FIL Ltd |
| 0.26% | <0.01% | #48 | $3.64亿 | 294.7万股 | $6,659 | 65股 | +294.6万股+4,532,986.15% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #117 | $3.20亿 | 258.9万股 | $2.56亿 | 250.1万股 | +8.8万股+3.53% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #144 | $3.04亿 | 245.9万股 | $2.49亿 | 242.8万股 | +3.1万股+1.26% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #135 | $2.58亿 | 209.1万股 | $2.09亿 | 203.6万股 | +5.5万股+2.71% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 3.21% | 2.3% | #14 | $2.20亿 | 178.3万股 | $1.41亿 | 137.6万股 | +40.7万股+29.57% | 加仓 |
| GLAZER CAPITAL, LLC |
| 5.44% | — | #8 | $2.19亿 | 177.0万股 | $0 | 0股 | +177.0万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.02% | 0.01% | #105 | $2.03亿 | 164.1万股 | $5,503.2万 | 53.7万股 | +110.4万股+205.47% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 2.93% | 3.16% | #15 | $1.95亿 | 158.1万股 | $1.62亿 | 158.1万股 | 00.00% | 持仓不变 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.23% | — | #50 | $1.82亿 | 147.0万股 | $0 | 0股 | +147.0万股 | 新买入 |
| 富达投资FMR LLC |
| 0.01% | 0.05% | #136 | $1.75亿 | 141.8万股 | $9.50亿 | 927.5万股 | -785.7万股-84.72% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #128 | $1.74亿 | 140.7万股 | $1.33亿 | 129.8万股 | +10.9万股+8.42% | 加仓 |
| 巴克莱BARCLAYS PLC |
| 0.03% | <0.01% | #94 | $1.57亿 | 126.8万股 | $316.0万 | 3.1万股 | +123.7万股+4,011.87% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 1.34% | 2.75% | #22 | $1.54亿 | 124.6万股 | $2.60亿 | 253.4万股 | -128.8万股-50.81% | 减仓 |
| Pentwater资本管理Pentwater Capital Management LP |
| 0.89% | — | #31 | $1.45亿 | 117.5万股 | $0 | 0股 | +117.5万股 | 新买入 |
| Bellevue 集团Bellevue Group AG |
| 2.74% | 2.57% | #16 | $1.30亿 | 105.3万股 | $1.08亿 | 105.3万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #139 | $1.08亿 | 87.7万股 | $2,218.2万 | 21.7万股 | +66.0万股+304.97% | 加仓 |
| First Trust Capital Management L.P. |
| 5.97% | — | #7 | $1.03亿 | 83.7万股 | $0 | 0股 | +83.7万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.03% | <0.01% | #92 | $9,405.7万 | 76.2万股 | $185.0万 | 1.8万股 | +74.4万股+4,117.71% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #160 | $8,413.1万 | 68.1万股 | $2,379.2万 | 27.5万股 | +40.6万股+147.62% | 加仓 |
| NEXPOINT ASSET MANAGEMENT, L.P. |
| 5.1% | — | #10 | $7,630.1万 | 61.8万股 | $0 | 0股 | +61.8万股 | 新买入 |
| AQR套利AQR Arbitrage LLC |
| 1.06% | — | #28 | $7,430.2万 | 60.2万股 | $0 | 0股 | +60.2万股 | 新买入 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.24% | — | #49 | $7,232.0万 | 58.6万股 | $0 | 0股 | +58.6万股 | 新买入 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | <0.01% | #140 | $6,916.5万 | 56.0万股 | $933.4万 | 13.2万股 | +42.8万股+325.50% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #137 | $6,275.3万 | 50.8万股 | $4,398.9万 | 42.9万股 | +7.9万股+18.34% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #134 | $5,807.2万 | 47.0万股 | $4,618.5万 | 45.1万股 | +1.9万股+4.31% | 加仓 |
| Verition基金管理Verition Fund Management LLC |
| 0.06% | — | #76 | $4,822.9万 | 39.1万股 | $0 | 0股 | +39.1万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #124 | $4,722.4万 | 38.2万股 | $3,730.9万 | 36.4万股 | +1.8万股+5.00% | 加仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.29% | — | #45 | $4,505.3万 | 36.5万股 | $0 | 0股 | +36.5万股 | 新买入 |
| 安联资产管理Allianz Asset Management GmbH |
| 0.04% | <0.01% | #86 | $4,422.0万 | 35.9万股 | $68.6万 | 6,700股 | +35.3万股+5,261.19% | 加仓 |
| Absolute Gestao de Investimentos Ltda. |
| 4.35% | — | #12 | $4,322.5万 | 35.0万股 | $0 | 0股 | +35.0万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | 0.02% | #187 | $4,079.3万 | 32.8万股 | $2.99亿 | 308.8万股 | -276.1万股-89.39% | 减仓 |
| 极地资产管理Polar Asset Management Partners Inc. |
| 0.65% | — | #34 | $3,958.5万 | 32.1万股 | $0 | 0股 | +32.1万股 | 新买入 |
| 索罗斯基金管理SOROS FUND MANAGEMENT LLC |
| 0.45% | — | #37 | $3,705.2万 | 30.0万股 | $0 | 0股 | +30.0万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #180 | $3,597.8万 | 29.1万股 | $376.5万 | 3.7万股 | +25.5万股+692.63% | 加仓 |
| Kryger Capital LLC |
| 2.02% | — | #19 | $3,540.9万 | 28.7万股 | $0 | 0股 | +28.7万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.05% | 0.01% | #81 | $3,469.1万 | 28.1万股 | $911.8万 | 8.9万股 | +19.2万股+215.62% | 加仓 |
| 白盒顾问WHITEBOX ADVISORS LLC |
| 0.44% | — | #38 | $3,396.3万 | 27.5万股 | $0 | 0股 | +27.5万股 | 新买入 |
| Affinity Asset Advisors, LLC |
| 1.54% | 1.59% | #21 | $3,396.3万 | 27.5万股 | $3,073.5万 | 30.0万股 | -2.5万股-8.33% | 减仓 |
| Cinctive 资本管理Cinctive Capital Management LP |
| 1.09% | — | #26 | $2,974.0万 | 24.1万股 | $0 | 0股 | +24.1万股 | 新买入 |
| ODDO BHF ASSET MANAGEMENT SAS |
| 1.31% | — | #24 | $2,808.2万 | 22.7万股 | $0 | 0股 | +22.7万股 | 新买入 |
| 安大略市政雇员退休系统(OMERS)OMERS ADMINISTRATION Corp |
| 0.17% | — | #53 | $2,784.9万 | 22.6万股 | $0 | 0股 | +22.6万股 | 新买入 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | 0.05% | #158 | $2,682.6万 | 21.7万股 | $2.53亿 | 247.0万股 | -225.3万股-91.21% | 减仓 |
| Slotnik Capital, LLC |
| 6.7% | — | #5 | $2,593.5万 | 21.0万股 | $0 | 0股 | +21.0万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.01% | #103 | $2,580.9万 | 20.9万股 | $1,046.2万 | 10.2万股 | +10.7万股+104.64% | 加仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.04% | <0.01% | #88 | $2,544.9万 | 20.6万股 | $42.5万 | 4,150股 | +20.2万股+4,865.49% | 加仓 |
| Sagefield Capital LP |
| 1.8% | — | #20 | $2,426.5万 | 19.6万股 | $0 | 0股 | +19.6万股 | 新买入 |
