| GREAT POINT PARTNERS LLC |
| 0.73% | 1.59% | #3 | $384.3万 | 94.4万股 | $692.7万 | 755.4万股 | -661.0万股-87.50% | 减仓 |
| Squadron Capital Management LLC |
| 0.96% | 2.56% | #2 | $308.1万 | 75.7万股 | $697.6万 | 760.9万股 | -685.2万股-90.05% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | — | #13 | $221.2万 | 54.3万股 | $0 | 0股 | +54.3万股 | 新买入 |
| Propel Bio Management, LLC |
| 1.16% | — | #1 | $221.2万 | 54.3万股 | $0 | 0股 | +54.3万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| <0.01% | — | #12 | $157.7万 | 38.8万股 | $0 | 0股 | +38.8万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $120.8万 | 29.7万股 | $143.5万 | 156.4万股 | -126.8万股-81.03% | 减仓 |
| Avidity Partners Management LP |
| 0.17% | 0.39% | #5 | $105.9万 | 26.0万股 | $190.9万 | 208.2万股 | -182.1万股-87.50% | 减仓 |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 0.1% | 0.2% | #8 | $100.9万 | 24.8万股 | $181.8万 | 198.2万股 | -173.5万股-87.50% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $73.6万 | 18.1万股 | $57.0万 | 62.2万股 | -44.1万股-70.94% | 减仓 |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 0.14% | 0.53% | #6 | $61.3万 | 15.1万股 | $191.4万 | 208.7万股 | -193.6万股-92.79% | 减仓 |
| DAFNA Capital Management LLC |
| 0.11% | 0.23% | #7 | $55.3万 | 13.6万股 | $99.7万 | 108.7万股 | -95.1万股-87.50% | 减仓 |
| Empery Asset Management, LP |
| 0.6% | 2.04% | #4 | $51.5万 | 12.6万股 | $169.4万 | 184.8万股 | -172.1万股-93.16% | 减仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #16 | $47.5万 | 11.7万股 | $67.0万 | 73.2万股 | -61.5万股-84.06% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #25 | $33.4万 | 8.2万股 | $44.6万 | 48.6万股 | -40.4万股-83.12% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #17 | $31.1万 | 7.7万股 | $20.6万 | 22.5万股 | -14.8万股-65.93% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #22 | $23.6万 | 5.8万股 | $20.7万 | 22.6万股 | -16.8万股-74.32% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.01% | — | #11 | $20.1万 | 4.9万股 | $0 | 0股 | +4.9万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #30 | $16.9万 | 4.2万股 | $30.5万 | 33.2万股 | -29.1万股-87.50% | 减仓 |
| Velan Capital Investment Management LP |
| 0.1% | — | #9 | $16.3万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #26 | $9.1万 | 2.2万股 | $8.8万 | 9.6万股 | -7.3万股-76.58% | 减仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #14 | $6.3万 | 1.6万股 | $11.4万 | 12.4万股 | -10.9万股-87.50% | 减仓 |
| Empowered FundsEmpowered Funds, LLC |
| <0.01% | <0.01% | #18 | $6.3万 | 1.5万股 | $11.3万 | 12.4万股 | -10.8万股-87.50% | 减仓 |
| WEALTH EFFECTS LLC |
| 0.02% | 0.03% | #10 | $5.6万 | 1.4万股 | $8.0万 | 8.8万股 | -7.4万股-84.14% | 减仓 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #15 | $5.3万 | 1.3万股 | $4.8万 | 5.2万股 | -3.9万股-75.21% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #28 | $4.6万 | 1.1万股 | $4 | 4股 | +1.1万股+280,475.00% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #27 | $4.1万 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #34 | $1.7万 | 4,093股 | $1.2万 | 1.6万股 | -1.2万股-73.93% | 减仓 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #31 | $3,810 | 936股 | $6,866 | 7,488股 | -6,552股-87.50% | 减仓 |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #21 | $2,646 | 650股 | $0 | 0股 | +650股 | 新买入 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #37 | $2,000 | 602股 | $1,000 | 820股 | -218股-26.59% | 减仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #33 | $1,591 | 391股 | $3,667 | 4,000股 | -3,609股-90.23% | 减仓 |
| 美国合众银行US BANCORP \DE\ |
| <0.01% | <0.01% | #32 | $1,575 | 387股 | $2,843 | 3,100股 | -2,713股-87.52% | 减仓 |
| 西北互惠财富管理NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
| <0.01% | <0.01% | #36 | $1,262 | 310股 | $2,280 | 2,487股 | -2,177股-87.54% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | — | #38 | $1,184 | 291股 | $0 | 0股 | +291股 | 新买入 |
| OSAIC控股OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #35 | $679 | 167股 | $1,586 | 1,730股 | -1,563股-90.35% | 减仓 |
| HighMark Wealth Management LLC |
| <0.01% | <0.01% | #20 | $537 | 132股 | $977 | 1,066股 | -934股-87.62% | 减仓 |
| Cornerstone Planning Group LLC |
| <0.01% | — | #24 | $146 | 37股 | $0 | 0股 | +37股 | 新买入 |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #29 | $118 | 29股 | $213 | 232股 | -203股-87.50% | 减仓 |
| Bogart Wealth, LLC |
| <0.01% | — | #39 | $4 | 1股 | $0 | 0股 | +1股 | 新买入 |
