| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 19.58% | 18.25% | #1 | $8.99亿 | 768.0万股 | $7.09亿 | 768.0万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.28% | — | #48 | $6.92亿 | 590.9万股 | $0 | 0股 | +590.9万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #162 | $5.14亿 | 439.0万股 | $3.55亿 | 384.7万股 | +54.4万股+14.13% | 加仓 |
| 富达投资FMR LLC |
| 0.02% | 0.01% | #128 | $4.30亿 | 367.0万股 | $1.82亿 | 196.5万股 | +170.5万股+86.75% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.02% | #115 | $3.11亿 | 265.6万股 | $1.59亿 | 171.7万股 | +93.8万股+54.63% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #141 | $2.78亿 | 237.7万股 | $1.32亿 | 143.2万股 | +94.5万股+65.98% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #182 | $2.64亿 | 225.4万股 | $2.23亿 | 241.5万股 | -16.1万股-6.65% | 减仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #163 | $2.54亿 | 217.1万股 | $1.80亿 | 194.4万股 | +22.6万股+11.64% | 加仓 |
| 威廉·布莱尔投资管理WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.49% | 0.1% | #36 | $1.64亿 | 140.5万股 | $3,100.9万 | 33.6万股 | +106.9万股+318.49% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #156 | $1.63亿 | 139.4万股 | $1.16亿 | 126.0万股 | +13.4万股+10.63% | 加仓 |
| 景顺Invesco Ltd. |
| 0.01% | <0.01% | #140 | $1.60亿 | 136.4万股 | $2,635.0万 | 28.5万股 | +107.9万股+378.23% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.02% | #119 | $1.53亿 | 131.0万股 | $1.23亿 | 133.5万股 | -2.5万股-1.86% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 1.95% | 2.15% | #18 | $1.46亿 | 124.8万股 | $1.30亿 | 140.9万股 | -16.0万股-11.39% | 减仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 6.57% | 5.8% | #4 | $1.45亿 | 123.6万股 | $1.14亿 | 123.6万股 | 00.00% | 持仓不变 |
| 资本世界投资者Capital World Investors |
| 0.02% | 0.01% | #131 | $1.35亿 | 115.3万股 | $6,692.1万 | 72.4万股 | +42.9万股+59.23% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.03% | 0.01% | #118 | $1.35亿 | 115.3万股 | $6,603.4万 | 71.5万股 | +43.8万股+61.27% | 加仓 |
| Novo Holdings A/S |
| 7.67% | 9.92% | #3 | $1.32亿 | 112.5万股 | $1.22亿 | 132.5万股 | -20.0万股-15.09% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 2.99% | 2.81% | #12 | $1.24亿 | 106.2万股 | $9,811.2万 | 106.2万股 | 00.00% | 持仓不变 |
| BVF INC/IL |
| 3.16% | 4.66% | #11 | $1.24亿 | 105.6万股 | $1.46亿 | 158.5万股 | -52.9万股-33.36% | 减仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.23% | 0.09% | #55 | $9,898.5万 | 84.6万股 | $2,618.8万 | 28.3万股 | +56.2万股+198.26% | 加仓 |
| Rock Springs Capital Management LP |
| 4.56% | 4.42% | #7 | $9,343.9万 | 79.8万股 | $7,494.7万 | 81.1万股 | -1.3万股-1.62% | 减仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.13% | 0.06% | #76 | $8,804.2万 | 75.2万股 | $3,744.4万 | 40.5万股 | +34.7万股+85.54% | 加仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.02% | <0.01% | #130 | $8,507.4万 | 72.7万股 | $2,025.5万 | 21.9万股 | +50.7万股+231.44% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.06% | #97 | $8,081.6万 | 69.0万股 | $7,158.0万 | 77.5万股 | -8.5万股-10.91% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.01% | 0.01% | #139 | $7,843.4万 | 67.0万股 | $5,399.8万 | 58.5万股 | +8.5万股+14.62% | 加仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.06% | 0.05% | #94 | $7,489.4万 | 64.0万股 | $6,206.7万 | 67.2万股 | -3.2万股-4.78% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.03% | 0.04% | #112 | $7,099.4万 | 60.6万股 | $8,419.7万 | 91.1万股 | -30.5万股-33.46% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.21% | 0.2% | #57 | $6,648.3万 | 56.8万股 | $5,246.2万 | 56.8万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #196 | $6,576.1万 | 56.2万股 | $6,671.5万 | 72.2万股 | -16.0万股-22.22% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #184 | $6,437.4万 | 55.0万股 | $6,118.4万 | 66.2万股 | -11.2万股-16.98% | 减仓 |
| LORD, ABBETT & CO. LLC |
| 0.18% | 0.19% | #62 | $6,333.2万 | 54.1万股 | $5,700.4万 | 61.7万股 | -7.6万股-12.33% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.06% | 0.04% | #96 | $6,163.1万 | 52.6万股 | $3,912.4万 | 42.4万股 | +10.3万股+24.30% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.07% | 0.06% | #87 | $5,726.7万 | 48.9万股 | $4,979.6万 | 53.9万股 | -5.0万股-9.25% | 减仓 |
| EMERALD ADVISERS, LLC |
| 1.29% | 1.16% | #23 | $5,482.3万 | 46.8万股 | $3,669.9万 | 39.7万股 | +7.1万股+17.88% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | <0.01% | #177 | $5,292.0万 | 45.2万股 | $3,648.3万 | 39.5万股 | +5.7万股+14.46% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #168 | $5,261.5万 | 44.9万股 | $3,945.5万 | 42.7万股 | +2.2万股+5.23% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.26% | 0.24% | #49 | $5,221.0万 | 44.6万股 | $4,119.9万 | 44.6万股 | 00.00% | 持仓不变 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.07% | 0.06% | #93 | $5,193.6万 | 44.4万股 | $4,391.0万 | 47.5万股 | -3.2万股-6.67% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.07% | 0.08% | #88 | $5,176.7万 | 44.2万股 | $5,377.3万 | 58.2万股 | -14.0万股-24.03% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.07% | 0.08% | #86 | $5,111.7万 | 43.7万股 | $4,676.4万 | 50.6万股 | -7.0万股-13.74% | 减仓 |
| NEXT CENTURY GROWTH INVESTORS LLC |
| 2.61% | 2.63% | #15 | $4,919.4万 | 42.0万股 | $3,561.6万 | 38.6万股 | +3.5万股+8.99% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.09% | 0.1% | #84 | $4,917.7万 | 42.0万股 | $4,429.4万 | 47.9万股 | -5.9万股-12.39% | 减仓 |
| BOONE CAPITAL MANAGEMENT LLC |
| 11.38% | 11.92% | #2 | $4,865.9万 | 41.6万股 | $3,891.4万 | 42.1万股 | -5,595股-1.33% | 减仓 |
| MFS马萨诸塞金融服务MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #133 | $4,502.2万 | 38.5万股 | $2,645.8万 | 28.6万股 | +9.8万股+34.27% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #181 | $4,445.9万 | 38.0万股 | $4,572.8万 | 49.5万股 | -11.5万股-23.28% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.2% | 0.23% | #59 | $4,399.3万 | 37.6万股 | $4,499.4万 | 57.0万股 | -19.3万股-33.96% | 减仓 |
| 时代广场资本管理TimesSquare Capital Management, LLC |
| 0.63% | 0.59% | #31 | $4,299.8万 | 36.7万股 | $3,477.9万 | 37.6万股 | -9,192股-2.44% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #223 | $4,113.9万 | 35.1万股 | $4,912.9万 | 67.0万股 | -31.9万股-47.56% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.06% | 0.05% | #99 | $4,097.5万 | 35.0万股 | $3,464.3万 | 37.5万股 | -2.5万股-6.67% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #154 | $4,076.7万 | 34.8万股 | $3,079.3万 | 33.3万股 | +1.5万股+4.47% | 加仓 |
