| 富达投资FMR LLC |
| 0.03% | 0.03% | #113 | $5.82亿 | 964.8万股 | $6.29亿 | 1,081.8万股 | -117.0万股-10.82% | 减仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #148 | $4.54亿 | 752.2万股 | $3.28亿 | 564.0万股 | +188.2万股+33.37% | 加仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 3.13% | 3.31% | #8 | $3.49亿 | 577.8万股 | $3.36亿 | 577.8万股 | 00.00% | 持仓不变 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.65% | 0.91% | #31 | $2.76亿 | 457.1万股 | $2.56亿 | 440.5万股 | +16.5万股+3.75% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.55% | 1.92% | #19 | $2.67亿 | 441.9万股 | $2.61亿 | 449.2万股 | -7.3万股-1.63% | 减仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.1% | — | #70 | $2.53亿 | 418.7万股 | $0 | 0股 | +418.7万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #119 | $1.96亿 | 324.8万股 | $7,731.7万 | 133.0万股 | +191.9万股+144.30% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| 0.01% | 0.01% | #141 | $1.57亿 | 261.7万股 | $1.07亿 | 192.4万股 | +69.4万股+36.07% | 加仓 |
| 资本国际投资者Capital International Investors |
| 0.03% | 0.04% | #106 | $1.43亿 | 236.2万股 | $1.56亿 | 267.5万股 | -31.3万股-11.71% | 减仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.09% | 0.04% | #78 | $1.31亿 | 216.9万股 | $5,535.7万 | 95.2万股 | +121.7万股+127.80% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #190 | $1.19亿 | 197.0万股 | $1.00亿 | 172.1万股 | +24.9万股+14.48% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.07% | 0.03% | #83 | $9,916.2万 | 164.3万股 | $3,524.4万 | 60.6万股 | +103.7万股+171.06% | 加仓 |
| Deerfield管理DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.02% | 1.11% | #24 | $9,752.3万 | 161.6万股 | $9,395.3万 | 161.6万股 | 00.00% | 持仓不变 |
| Affinity Asset Advisors, LLC |
| 4.35% | 5.03% | #4 | $9,627.4万 | 159.5万股 | $9,740.1万 | 167.5万股 | -8.0万股-4.78% | 减仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.3% | 0.34% | #44 | $9,098.0万 | 150.7万股 | $8,149.6万 | 140.1万股 | +10.6万股+7.55% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.03% | 0.02% | #103 | $9,084.6万 | 156.2万股 | $6,289.6万 | 140.3万股 | +15.9万股+11.33% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | 0.03% | #137 | $8,741.0万 | 144.8万股 | $1.68亿 | 288.6万股 | -143.8万股-49.83% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.02% | 0.02% | #121 | $8,678.0万 | 143.8万股 | $7,446.6万 | 128.1万股 | +15.7万股+12.27% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.05% | #129 | $8,604.3万 | 142.5万股 | $2.81亿 | 483.0万股 | -340.4万股-70.48% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #172 | $8,269.3万 | 137.0万股 | $6,354.5万 | 109.3万股 | +27.7万股+25.36% | 加仓 |
| Siren, L.L.C. |
| 1.61% | 2.13% | #18 | $7,958.9万 | 131.9万股 | $7,667.4万 | 131.9万股 | 00.00% | 持仓不变 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.08% | — | #80 | $7,790.9万 | 129.1万股 | $0 | 0股 | +129.1万股 | 新买入 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.07% | 0.04% | #84 | $7,164.5万 | 118.8万股 | $3,922.9万 | 68.0万股 | +50.8万股+74.74% | 加仓 |
| BRAIDWELL LP |
| 2.53% | 2.6% | #12 | $6,829.4万 | 113.1万股 | $7,783.1万 | 133.8万股 | -20.7万股-15.47% | 减仓 |
| 纽文Nuveen, LLC |
| 0.01% | <0.01% | #132 | $5,994.5万 | 99.3万股 | $1,454.0万 | 25.0万股 | +74.3万股+297.19% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #175 | $5,453.3万 | 90.3万股 | $343.7万 | 5.9万股 | +84.4万股+1,428.62% | 加仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.02% | 1.22% | #25 | $5,387.0万 | 89.2万股 | $6,163.7万 | 106.0万股 | -16.8万股-15.80% | 减仓 |
| Caligan Partners LP |
| 2.53% | 5.39% | #11 | $5,371.7万 | 89.0万股 | $8,100.5万 | 139.3万股 | -50.3万股-36.11% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #115 | $5,337.8万 | 88.4万股 | $3,950.2万 | 67.9万股 | +20.5万股+30.18% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.08% | 0.09% | #81 | $5,334.2万 | 88.4万股 | $5,653.6万 | 97.2万股 | -8.9万股-9.10% | 减仓 |
| 资本世界投资者Capital World Investors |
| 0.01% | 0.01% | #155 | $5,207.7万 | 86.3万股 | $4,885.0万 | 84.0万股 | +2.3万股+2.70% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #178 | $4,669.6万 | 77.4万股 | $4,476.8万 | 77.0万股 | +3,750股+0.49% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #207 | $4,524.9万 | 75.0万股 | $3,157.9万 | 54.3万股 | +20.7万股+38.04% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.2% | 0.45% | #51 | $4,394.2万 | 72.8万股 | $7,779.9万 | 133.8万股 | -61.0万股-45.59% | 减仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.99% | 1.04% | #26 | $4,225.2万 | 70.0万股 | $3,721.0万 | 64.0万股 | +6.0万股+9.39% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.11% | 0.21% | #68 | $4,211.3万 | 69.8万股 | $7,556.4万 | 129.9万股 | -60.2万股-46.31% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.03% | — | #101 | $4,160.9万 | 68.9万股 | $0 | 0股 | +68.9万股 | 新买入 |
| Rock Springs Capital Management LP |
| 2.01% | 2.62% | #15 | $4,128.1万 | 68.4万股 | $4,437.0万 | 76.3万股 | -7.9万股-10.37% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #168 | $4,053.6万 | 67.2万股 | $3,069.1万 | 52.8万股 | +14.4万股+27.24% | 加仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| 0.12% | — | #66 | $4,008.1万 | 66.4万股 | $0 | 0股 | +66.4万股 | 新买入 |
| First Turn Management, LLC |
| 3.88% | 5.11% | #6 | $3,622.8万 | 60.0万股 | $4,575.5万 | 78.7万股 | -18.7万股-23.72% | 减仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| 0.05% | 0.06% | #93 | $3,292.0万 | 54.5万股 | $3,157.5万 | 54.3万股 | +2,396股+0.44% | 加仓 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.04% | 0.04% | #95 | $3,182.6万 | 52.7万股 | $3,284.9万 | 56.5万股 | -3.8万股-6.66% | 减仓 |
| Octagon Capital Advisors LP |
| 2.66% | 3.15% | #10 | $2,957.6万 | 49.0万股 | $2,849.4万 | 49.0万股 | 00.00% | 持仓不变 |
| Novo Holdings A/S |
| 1.71% | 2.29% | #17 | $2,930.1万 | 48.5万股 | $2,822.8万 | 48.5万股 | 00.00% | 持仓不变 |
| 康得利安资管Candriam S.C.A. |
| 0.13% | 0.09% | #65 | $2,790.6万 | 46.3万股 | $1,870.9万 | 41.7万股 | +4.5万股+10.87% | 加仓 |
| 时代广场资本管理TimesSquare Capital Management, LLC |
| 0.4% | 0.35% | #40 | $2,725.8万 | 45.2万股 | $2,089.3万 | 35.9万股 | +9.2万股+25.69% | 加仓 |
| Logos Global Management LP |
| 1.17% | 1.31% | #23 | $2,716.2万 | 45.0万股 | $2,616.8万 | 45.0万股 | 00.00% | 持仓不变 |
| Trails Edge Capital Partners, LP |
| 4.22% | 8.53% | #5 | $2,655.8万 | 44.0万股 | $3,721.6万 | 64.0万股 | -20.0万股-31.25% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #176 | $2,544.3万 | 42.2万股 | $2,303.5万 | 39.6万股 | +2.5万股+6.41% | 加仓 |
