| Essex Woodlands Management, Inc. |
| 2.28% | 1.91% | #1 | $578.6万 | 771.5万股 | $478.3万 | 771.5万股 | 00.00% | 持仓不变 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.15% | 0.13% | #6 | $442.1万 | 589.4万股 | $365.4万 | 589.4万股 | 00.00% | 持仓不变 |
| Stonepine Capital Management, LLC |
| 0.31% | 0.65% | #3 | $199.7万 | 266.2万股 | $162.3万 | 261.7万股 | +4.5万股+1.73% | 加仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.17% | 0.14% | #5 | $160.3万 | 213.7万股 | $140.1万 | 225.9万股 | -12.2万股-5.40% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #22 | $117.6万 | 156.8万股 | $95.5万 | 154.1万股 | +2.8万股+1.79% | 加仓 |
| DAFNA Capital Management LLC |
| 0.21% | 0.2% | #4 | $108.1万 | 144.1万股 | $89.3万 | 144.1万股 | 00.00% | 持仓不变 |
| PERKINS CAPITAL MANAGEMENT INC |
| 0.81% | 0.83% | #2 | $103.1万 | 137.5万股 | $87.9万 | 141.8万股 | -4.3万股-3.05% | 减仓 |
| Sio Capital Management, LLC |
| 0.08% | 0.06% | #7 | $47.7万 | 63.6万股 | $39.5万 | 63.6万股 | 00.00% | 持仓不变 |
| WealthTrust Axiom LLC |
| 0.08% | 0.06% | #8 | $34.3万 | 45.8万股 | $23.4万 | 37.7万股 | +8.1万股+21.43% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #24 | $29.2万 | 38.9万股 | $28.2万 | 45.5万股 | -6.6万股-14.47% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #31 | $28.1万 | 37.5万股 | $28.9万 | 46.6万股 | -9.1万股-19.60% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #21 | $16.0万 | 21.3万股 | $13.1万 | 21.2万股 | +1,476股+0.70% | 加仓 |
| UP STRATEGIC WEALTH INVESTMENT ADVISORS LLC |
| 0.05% | 0.07% | #9 | $9.1万 | 10.0万股 | $11.0万 | 10.0万股 | 00.00% | 持仓不变 |
| Embree Financial Group |
| 0.01% | 0.01% | #12 | $6.8万 | 9.1万股 | $7.3万 | 11.8万股 | -2.7万股-23.08% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #29 | $5.6万 | 7.5万股 | $10.8万 | 17.4万股 | -10.0万股-57.12% | 减仓 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #26 | $5.1万 | 6.8万股 | $3.1万 | 5.0万股 | +1.8万股+36.22% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #35 | $4.8万 | 6.3万股 | $3.9万 | 6.3万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #19 | $4.4万 | 5.8万股 | $3.3万 | 5.3万股 | +5,500股+10.46% | 加仓 |
| PNC金融服务集团PNC FINANCIAL SERVICES GROUP, INC. |
| <0.01% | <0.01% | #23 | $4.0万 | 5.4万股 | $3.3万 | 5.4万股 | 00.00% | 持仓不变 |
| Destiny Wealth Partners, LLC |
| 0.01% | <0.01% | #13 | $3.8万 | 5.3万股 | $3.3万 | 5.3万股 | 00.00% | 持仓不变 |
| Ducere Wealth Management LLC |
| 0.01% | 0.01% | #10 | $3.8万 | 5.1万股 | $2.4万 | 2.0万股 | +3.1万股+155.00% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | — | #33 | $3.7万 | 4.9万股 | $0 | 0股 | +4.9万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #32 | $2.5万 | 3.3万股 | $65.7万 | 106.0万股 | -102.6万股-96.84% | 减仓 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #15 | $2.2万 | 3.0万股 | $9,407 | 1.5万股 | +1.4万股+94.81% | 加仓 |
| 道明加拿大TD Waterhouse Canada Inc. |
| <0.01% | — | #20 | $1.7万 | 2.3万股 | $0 | 0股 | +2.3万股 | 新买入 |
| PRIMORIS WEALTH ADVISORS, LLC |
| 0.01% | — | #11 | $1.5万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| 大谷顾问集团GREAT VALLEY ADVISOR GROUP, INC. |
| <0.01% | <0.01% | #17 | $1.5万 | 2.0万股 | $1.2万 | 2.0万股 | -101股-0.51% | 减仓 |
| J.W.科尔顾问J.W. COLE ADVISORS, INC. |
| <0.01% | — | #18 | $1.2万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| Atom Investors LP |
| <0.01% | — | #14 | $1.2万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 美世全球顾问MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #25 | $1.1万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #16 | $1.0万 | 1.4万股 | $548 | 884股 | +1.3万股+1,439.82% | 加仓 |
| HighTower顾问HighTower Advisors, LLC |
| <0.01% | <0.01% | #27 | $8,400 | 1.1万股 | $6,944 | 1.1万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | — | #36 | $7,787 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #34 | $3,453 | 4,604股 | $2,854 | 4,604股 | 00.00% | 持仓不变 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #38 | $3,150 | 4,200股 | $2,604 | 4,200股 | 00.00% | 持仓不变 |
| Steward合伙人投资顾问Steward Partners Investment Advisory, LLC |
| <0.01% | <0.01% | #28 | $1,493 | 1,991股 | $1,234 | 1,991股 | 00.00% | 持仓不变 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #39 | $1,331 | 1,774股 | $46.5万 | 75.0万股 | -74.8万股-99.76% | 减仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #37 | $957 | 1,276股 | $88 | 143股 | +1,133股+792.31% | 加仓 |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #30 | $226 | 301股 | $187 | 301股 | 00.00% | 持仓不变 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #41 | $158 | 210股 | $133 | 214股 | -4股-1.87% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | — | #42 | $156 | 208股 | $0 | 0股 | +208股 | 新买入 |
| OSAIC控股OSAIC HOLDINGS, INC. |
| <0.01% | — | #40 | $75 | 100股 | $0 | 0股 | +100股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #43 | $28 | 37股 | $3,306 | 2,219股 | -2,182股-98.33% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #43 | $28 | 39股 | $22 | 39股 | 00.00% | 持仓不变 |
