| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 6.43% | 6.14% | #3 | $7.40亿 | 666.7万股 | $5.80亿 | 666.7万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #123 | $6.84亿 | 615.7万股 | $5.42亿 | 623.7万股 | -8.0万股-1.29% | 减仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 3.12% | 2.8% | #8 | $6.22亿 | 560.4万股 | $4.87亿 | 560.4万股 | 00.00% | 持仓不变 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| 0.21% | 0.23% | #43 | $3.52亿 | 316.9万股 | $2.97亿 | 341.8万股 | -24.9万股-7.28% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.01% | #100 | $3.48亿 | 313.7万股 | $2.64亿 | 304.1万股 | +9.6万股+3.16% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #141 | $3.34亿 | 300.6万股 | $2.58亿 | 296.8万股 | +3.8万股+1.29% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| 0.02% | 0.01% | #99 | $2.92亿 | 265.3万股 | $1.20亿 | 155.4万股 | +109.9万股+70.74% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 4.31% | 4.03% | #4 | $2.87亿 | 258.6万股 | $2.06亿 | 237.4万股 | +21.3万股+8.95% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #130 | $2.86亿 | 257.4万股 | $1.98亿 | 227.2万股 | +30.2万股+13.28% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.02% | #86 | $2.85亿 | 256.6万股 | $1.44亿 | 165.5万股 | +91.1万股+55.07% | 加仓 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.8% | 0.7% | #21 | $2.45亿 | 220.9万股 | $1.68亿 | 192.9万股 | +27.9万股+14.49% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.02% | 0.02% | #93 | $2.36亿 | 212.7万股 | $1.71亿 | 196.5万股 | +16.1万股+8.20% | 加仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.29% | 0.18% | #37 | $1.98亿 | 178.6万股 | $1.12亿 | 128.6万股 | +49.9万股+38.83% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.44% | 0.5% | #27 | $1.85亿 | 166.4万股 | $1.41亿 | 161.6万股 | +4.8万股+2.97% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #125 | $1.70亿 | 153.4万股 | $1.23亿 | 141.6万股 | +11.7万股+8.29% | 加仓 |
| 资本研究全球投资者Capital Research Global Investors |
| 0.02% | 0.02% | #91 | $1.70亿 | 153.2万股 | $9,701.2万 | 111.5万股 | +41.7万股+37.37% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.02% | 0.02% | #96 | $1.45亿 | 130.9万股 | $1.26亿 | 145.3万股 | -14.4万股-9.90% | 减仓 |
| Checkpoint Capital L.P. |
| 33.79% | 38.3% | #1 | $1.32亿 | 118.6万股 | $1.07亿 | 122.7万股 | -4.1万股-3.36% | 减仓 |
| Siren, L.L.C. |
| 2.55% | 1.75% | #9 | $1.26亿 | 113.6万股 | $6,309.8万 | 72.6万股 | +41.1万股+56.62% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #145 | $1.23亿 | 111.2万股 | $4,698.0万 | 46.5万股 | +64.7万股+139.09% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | 0.01% | #156 | $1.14亿 | 102.6万股 | $1.47亿 | 169.0万股 | -66.4万股-39.29% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.1% | 0.06% | #52 | $1.06亿 | 95.8万股 | $5,732.9万 | 66.7万股 | +29.1万股+43.59% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.04% | — | #79 | $1.03亿 | 92.5万股 | $0 | 0股 | +92.5万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.26% | 0.25% | #39 | $8,426.0万 | 75.9万股 | $6,600.1万 | 75.9万股 | 00.00% | 持仓不变 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.03% | 0.03% | #87 | $7,781.4万 | 89.5万股 | $9,745.1万 | 91.0万股 | -1.6万股-1.72% | 减仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.06% | 0.05% | #64 | $7,732.9万 | 69.6万股 | $5,300.3万 | 60.9万股 | +8.7万股+14.28% | 加仓 |
| Rock Springs Capital Management LP |
| 3.75% | 3.54% | #6 | $7,689.9万 | 69.3万股 | $5,998.7万 | 69.0万股 | +2,850股+0.41% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | <0.01% | #137 | $7,614.9万 | 68.6万股 | $1,183.8万 | 22.3万股 | +46.2万股+206.89% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #108 | $6,406.8万 | 57.7万股 | $5,451.7万 | 62.7万股 | -5.0万股-7.95% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #133 | $6,137.1万 | 55.3万股 | $4,578.6万 | 52.6万股 | +2.6万股+4.99% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 2.41% | 2.5% | #10 | $6,106.7万 | 55.0万股 | $5,218.2万 | 60.0万股 | -5.0万股-8.33% | 减仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #159 | $6,031.9万 | 54.3万股 | $3,168.4万 | 36.4万股 | +17.9万股+49.12% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #142 | $5,999.3万 | 54.0万股 | $4,335.6万 | 49.9万股 | +4.2万股+8.39% | 加仓 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | 0.01% | #122 | $5,716.4万 | 51.5万股 | $4,709.0万 | 54.1万股 | -2.7万股-4.91% | 减仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | <0.01% | #124 | $5,426.6万 | 48.9万股 | $2,380.9万 | 27.4万股 | +21.5万股+78.53% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #116 | $4,948.9万 | 44.6万股 | $3,669.4万 | 42.2万股 | +2.4万股+5.64% | 加仓 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.06% | 0.05% | #67 | $4,819.8万 | 43.4万股 | $4,045.0万 | 46.5万股 | -3.1万股-6.67% | 减仓 |
| 康得利安资管Candriam S.C.A. |
| 0.22% | 0.15% | #42 | $4,803.3万 | 43.3万股 | $3,081.9万 | 28.8万股 | +14.5万股+50.40% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| 0.05% | 0.03% | #73 | $4,695.7万 | 42.3万股 | $2,287.0万 | 26.3万股 | +16.0万股+60.83% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.05% | 0.09% | #76 | $4,599.0万 | 41.4万股 | $7,364.6万 | 84.7万股 | -43.3万股-51.09% | 减仓 |
| Sofinnova Investments, Inc. |
| 2.34% | 1.49% | #11 | $4,530.3万 | 40.8万股 | $3,914.5万 | 45.0万股 | -4.2万股-9.35% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.01% | 0.01% | #126 | $4,459.4万 | 40.2万股 | $3,339.3万 | 38.4万股 | +1.8万股+4.60% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.06% | 0.1% | #66 | $4,407.9万 | 39.7万股 | $6,311.8万 | 72.6万股 | -32.9万股-45.30% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.01% | <0.01% | #140 | $4,375.1万 | 39.4万股 | $2,550.8万 | 29.3万股 | +10.1万股+34.35% | 加仓 |
| BRAIDWELL LP |
| 1.57% | 0.9% | #14 | $4,231.7万 | 38.1万股 | $2,701.5万 | 31.1万股 | +7.1万股+22.70% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.06% | 0.05% | #65 | $3,939.5万 | 35.5万股 | $3,397.6万 | 39.1万股 | -3.6万股-9.18% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #189 | $3,613.7万 | 32.5万股 | $5,467.5万 | 62.9万股 | -30.3万股-48.23% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.68% | 0.54% | #24 | $3,585.2万 | 32.3万股 | $2,731.7万 | 31.4万股 | +8,800股+2.80% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.01% | 0.02% | #111 | $3,516.5万 | 31.7万股 | $3,929.5万 | 45.2万股 | -13.5万股-29.90% | 减仓 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 3.59% | 2.72% | #7 | $3,458.2万 | 31.1万股 | $2,661.3万 | 30.6万股 | +5,461股+1.78% | 加仓 |
