| 富达投资FMR LLC |
| 0.05% | 0.05% | #62 | $12.12亿 | 2,085.3万股 | $9.58亿 | 1,649.3万股 | +436.0万股+26.44% | 加仓 |
| 木星资产管理Jupiter Topco LLC |
| 0.43% | — | #36 | $10.44亿 | 1,796.6万股 | $0 | 0股 | +1,796.6万股 | 新买入 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 0.47% | 0.49% | #32 | $7.10亿 | 1,220.7万股 | $7.05亿 | 1,212.6万股 | +8.1万股+0.67% | 加仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #120 | $7.02亿 | 1,206.8万股 | $6.38亿 | 1,097.2万股 | +109.6万股+9.99% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 5.8% | 7.07% | #7 | $6.67亿 | 1,147.5万股 | $6.67亿 | 1,147.5万股 | 00.00% | 持仓不变 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.06% | #55 | $4.07亿 | 700.2万股 | $3.26亿 | 561.5万股 | +138.7万股+24.70% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.02% | #93 | $3.83亿 | 659.4万股 | $3.65亿 | 628.0万股 | +31.4万股+5.00% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #135 | $3.69亿 | 634.9万股 | $3.64亿 | 626.7万股 | +8.2万股+1.31% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #127 | $3.11亿 | 535.2万股 | $2.58亿 | 444.1万股 | +91.1万股+20.52% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 3.64% | 4.08% | #8 | $2.50亿 | 430.0万股 | $2.50亿 | 430.0万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #119 | $2.01亿 | 345.9万股 | $1.86亿 | 320.1万股 | +25.8万股+8.06% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #94 | $1.74亿 | 298.9万股 | $5,674.1万 | 97.6万股 | +201.3万股+206.12% | 加仓 |
| Kynam Capital Management, LP |
| 9.39% | 10.48% | #3 | $1.70亿 | 292.2万股 | $1.70亿 | 292.2万股 | 00.00% | 持仓不变 |
| Westfield资本管理WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.47% | 0.89% | #31 | $1.44亿 | 247.2万股 | $2.12亿 | 364.6万股 | -117.4万股-32.19% | 减仓 |
| Caligan Partners LP |
| 5.99% | 7.97% | #6 | $1.27亿 | 218.9万股 | $1.20亿 | 206.1万股 | +12.8万股+6.21% | 加仓 |
| 范式生物资本Paradigm Biocapital Advisors LP |
| 2.32% | 5.69% | #18 | $1.24亿 | 212.8万股 | $2.79亿 | 479.3万股 | -266.5万股-55.61% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | <0.01% | #126 | $1.21亿 | 207.9万股 | $4,403.4万 | 75.8万股 | +132.1万股+174.29% | 加仓 |
| Bellevue 集团Bellevue Group AG |
| 2.41% | 1.65% | #16 | $1.15亿 | 197.2万股 | $6,919.1万 | 119.1万股 | +78.1万股+65.61% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.05% | 0.1% | #61 | $1.11亿 | 190.2万股 | $1.67亿 | 286.5万股 | -96.3万股-33.62% | 减仓 |
| Caption管理Caption Management, LLC |
| 0.46% | 0.24% | #33 | $9,864.1万 | 169.7万股 | $4,086.3万 | 70.3万股 | +99.4万股+141.31% | 加仓 |
| Maverick资本MAVERICK CAPITAL LTD |
| 0.83% | 0.92% | #27 | $9,377.8万 | 161.3万股 | $8,006.0万 | 137.8万股 | +23.6万股+17.09% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #117 | $8,515.0万 | 146.5万股 | $8,158.3万 | 140.4万股 | +6.1万股+4.34% | 加仓 |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 26.92% | 28.51% | #1 | $8,286.3万 | 142.5万股 | $7,975.2万 | 137.2万股 | +5.3万股+3.87% | 加仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 1.07% | 1.32% | #23 | $8,022.9万 | 138.0万股 | $7,984.0万 | 137.4万股 | +5,927股+0.43% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #149 | $7,997.9万 | 137.6万股 | $7,555.1万 | 130.0万股 | +7.6万股+5.82% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #129 | $7,441.6万 | 128.0万股 | $6,650.5万 | 114.4万股 | +13.6万股+11.86% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | <0.01% | #144 | $7,241.9万 | 124.6万股 | $3,397.8万 | 90.0万股 | +34.6万股+38.45% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #181 | $7,119.0万 | 122.7万股 | $5,541.7万 | 100.8万股 | +21.9万股+21.72% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #109 | $6,944.6万 | 119.5万股 | $2,183.6万 | 37.6万股 | +81.9万股+217.95% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.16% | 0.29% | #46 | $6,893.9万 | 118.6万股 | $8,285.3万 | 142.6万股 | -24.0万股-16.82% | 减仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.89% | 0.54% | #25 | $6,677.8万 | 114.9万股 | $4,203.2万 | 72.3万股 | +42.5万股+58.82% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #178 | $6,271.1万 | 107.9万股 | $7,071.1万 | 121.7万股 | -13.8万股-11.34% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #113 | $5,409.8万 | 93.1万股 | $4,894.4万 | 84.2万股 | +8.8万股+10.49% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.07% | 0.03% | #54 | $5,115.4万 | 88.0万股 | $2,033.9万 | 35.0万股 | +53.0万股+151.43% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | 0.01% | #175 | $5,041.6万 | 86.7万股 | $6,165.3万 | 106.1万股 | -19.4万股-18.25% | 减仓 |
| Saturn V Capital Management LP |
| 7.11% | 8.68% | #4 | $4,958.0万 | 85.3万股 | $4,791.4万 | 82.5万股 | +2.8万股+3.44% | 加仓 |
| 资本研究全球投资者Capital Research Global Investors |
| 0.01% | 0.01% | #150 | $4,864.1万 | 83.7万股 | $5,303.6万 | 91.3万股 | -7.6万股-8.32% | 减仓 |
| Novo Holdings A/S |
| 2.71% | 4.05% | #14 | $4,650.4万 | 80.0万股 | $4,997.5万 | 86.0万股 | -6.0万股-6.98% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #199 | $4,637.1万 | 79.8万股 | $2,825.7万 | 78.4万股 | +1.3万股+1.69% | 加仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.01% | #90 | $4,546.8万 | 78.2万股 | $2,067.9万 | 35.6万股 | +42.6万股+119.80% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.01% | #157 | $4,513.9万 | 77.7万股 | $7,771.6万 | 133.7万股 | -56.1万股-41.94% | 减仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.04% | 0.01% | #79 | $4,371.4万 | 75.2万股 | $746.0万 | 12.8万股 | +62.4万股+485.77% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.04% | 0.04% | #75 | $4,038.4万 | 69.5万股 | $4,069.5万 | 70.0万股 | -5,592股-0.80% | 减仓 |
| Eversept Partners, LP |
| 1.9% | 2.83% | #20 | $3,661.9万 | 63.0万股 | $5,370.5万 | 92.4万股 | -29.4万股-31.84% | 减仓 |
| Federated HermesFEDERATED HERMES, INC. |
| 0.05% | 0.05% | #65 | $3,494.5万 | 60.1万股 | $3,293.8万 | 56.7万股 | +3.4万股+6.06% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| 0.36% | 0.32% | #39 | $2,995.7万 | 51.5万股 | $2,115.1万 | 36.4万股 | +15.1万股+41.58% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | 0.01% | #165 | $2,918.9万 | 50.2万股 | $2,757.5万 | 47.5万股 | +2.8万股+5.82% | 加仓 |
| 布朗顾问BROWN ADVISORY INC |
| 0.04% | 0.05% | #71 | $2,831.0万 | 48.7万股 | $2,973.5万 | 51.2万股 | -2.5万股-4.82% | 减仓 |
| 詹尼森联营JENNISON ASSOCIATES LLC |
| 0.02% | 0.07% | #96 | $2,768.2万 | 47.6万股 | $9,867.1万 | 169.8万股 | -122.2万股-71.95% | 减仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #158 | $2,767.0万 | 47.6万股 | $2,750.7万 | 47.3万股 | +2,641股+0.56% | 加仓 |
